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Protein

Histone H1.1

Gene

Hist1h1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

H1 histones bind to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. H1 histones are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1.1
Alternative name(s):
Histone H1a
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1305706 Hist1h1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004191322 – 214Histone H1.1Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Modified residuei17N6-acetyllysineBy similarity1
Modified residuei36N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei43PhosphoserineCombined sources1
Modified residuei54N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei56CitrullineBy similarity1
Modified residuei66N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei67PhosphoserineCombined sources1
Modified residuei77N6-acetyllysineBy similarity1
Modified residuei87N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei92N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei92N6-acetyllysine; alternateBy similarity1
Modified residuei106PhosphoserineBy similarity1
Modified residuei108N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei121N6-acetyllysineBy similarity1
Modified residuei202PhosphothreonineBy similarity1

Post-translational modificationi

H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.By similarity
Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity

Keywords - PTMi

Acetylation, Citrullination, Hydroxylation, Phosphoprotein

Proteomic databases

PaxDbiD4A3K5
PeptideAtlasiD4A3K5
PRIDEiD4A3K5

PTM databases

iPTMnetiD4A3K5
PhosphoSitePlusiD4A3K5

Expressioni

Gene expression databases

BgeeiENSRNOG00000017175

Interactioni

Subunit structurei

Interacts with DFFB.By similarity

Protein-protein interaction databases

BioGridi253432, 8 interactors
IntActiD4A3K5, 1 interactor
STRINGi10116.ENSRNOP00000023054

Structurei

3D structure databases

ProteinModelPortaliD4A3K5
SMRiD4A3K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 111H15PROSITE-ProRule annotationAdd BLAST74

Domaini

The C-terminal domain is required for high-affinity binding to chromatin.By similarity

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00670000097781
InParanoidiD4A3K5
KOiK11275
OMAiKDEANPP
OrthoDBiEOG091G0XGD
PhylomeDBiD4A3K5
TreeFamiTF313664

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4A3K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETAPVPQP ASVAPEKPAA TKKTRKPAKA AVPRKKPAGP SVSELIVQAV
60 70 80 90 100
SSSKERSGVS LAALKKSLAA AGYDVEKNNS RIKLGLKSLV NKGTLVQTKG
110 120 130 140 150
TGAAGSFKLN KKAESKASTT KVTVKAKASG AAKKPKKTAG AAAKKTVKTP
160 170 180 190 200
KKPKKPAVSK KTSSKSPKKP KVVKAKKVAK SPAKAKAVKP KAAKVKVTKP
210
KTPAKPKKAA PKKK
Length:214
Mass (Da):22,004
Last modified:April 20, 2010 - v1
Checksum:i154211E35249E239
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06091665 Genomic DNA No translation available.
CH474064 Genomic DNA Translation: EDL86563.1
RefSeqiNP_001099583.1, NM_001106113.1
UniGeneiRn.218709

Genome annotation databases

EnsembliENSRNOT00000023054; ENSRNOP00000023054; ENSRNOG00000017175
GeneIDi291145
KEGGirno:291145
UCSCiRGD:1305706 rat

Similar proteinsi

Entry informationi

Entry nameiH11_RAT
AccessioniPrimary (citable) accession number: D4A3K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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