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Protein

Kelch-like protein 21

Gene

Klhl21

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 21
Gene namesi
Name:Klhl21
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1305863. Klhl21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 597597Kelch-like protein 21PRO_0000396631Add
BLAST

Proteomic databases

PaxDbiD4A2K4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003334.
GenevisibleiD4A2K4. RN.

Interactioni

Subunit structurei

Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004508.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 10369BTBPROSITE-ProRule annotationAdd
BLAST
Domaini138 – 239102BACKAdd
BLAST
Repeati287 – 33549Kelch 1Add
BLAST
Repeati336 – 38247Kelch 2Add
BLAST
Repeati384 – 42239Kelch 3Add
BLAST
Repeati423 – 47048Kelch 4Add
BLAST
Repeati472 – 51241Kelch 5Add
BLAST
Repeati513 – 56048Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
InParanoidiD4A2K4.
KOiK10458.
OMAiWVRADPP.
OrthoDBiEOG091G0380.
PhylomeDBiD4A2K4.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A2K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPAPLAVL PFSDPAHALS LLRGLSQLRA ERKFLDVTLE AAGGRDFPAH
60 70 80 90 100
RAVLAAASPY FRAMFAGQLR ESRAERVRLH GVPPDMLQLL LDFSYTGRVA
110 120 130 140 150
VSGDNAEPLL RAADLLQFPA VKEACGAFLQ QQLDLANCLD MQDFAEAFSC
160 170 180 190 200
SGLASAAQRF ILRHVGELGA EQLERLPLAR LLRYLRDDGL CVPKEEAAYQ
210 220 230 240 250
LALRWVRADP PRRAAHWPQL LEAVRLPFVR RFYLLAHVEA EPLVARCPPC
260 270 280 290 300
LRLLREARDF QAARYDRHDR GPCPRMRPRP STGLAEILVL VGGCDQDCDE
310 320 330 340 350
LVTVDCYNPQ TGQWRYLAEF PDHLGGGYSI VALGNDIYVT GGSDGSRLYD
360 370 380 390 400
CVWRYNSSVN EWTEVAPMLK AREYHSSSVL NGLLYVVAAD STERYDHATD
410 420 430 440 450
SWEALQPMTY PMDNCSTTAC RGRLYAIGSL AGKETMVIQC YDPDTDLWSM
460 470 480 490 500
VNCGQLPPWS FAPKTVTLNG LMYFVRDDSA EVDVYNPTKD EWDKIPSMNQ
510 520 530 540 550
VHVGGSLAAL GGKLYVSGGY DNTFELSDVV EAYDPETRAW SVVGRLPEPT
560 570 580 590
FWHGSVSIFR QFMPQTPAGG RGFELNSGSS DVDAGHHRLP QNPEELQ
Length:597
Mass (Da):66,448
Last modified:April 20, 2010 - v1
Checksum:iBB40E784787D3124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473968 Genomic DNA. Translation: EDL81211.1.
RefSeqiNP_001101466.1. NM_001107996.1.
UniGeneiRn.87563.

Genome annotation databases

EnsembliENSRNOT00000004508; ENSRNOP00000004508; ENSRNOG00000003334.
GeneIDi313743.
KEGGirno:313743.
UCSCiRGD:1305863. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473968 Genomic DNA. Translation: EDL81211.1.
RefSeqiNP_001101466.1. NM_001107996.1.
UniGeneiRn.87563.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004508.

Proteomic databases

PaxDbiD4A2K4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004508; ENSRNOP00000004508; ENSRNOG00000003334.
GeneIDi313743.
KEGGirno:313743.
UCSCiRGD:1305863. rat.

Organism-specific databases

CTDi9903.
RGDi1305863. Klhl21.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
InParanoidiD4A2K4.
KOiK10458.
OMAiWVRADPP.
OrthoDBiEOG091G0380.
PhylomeDBiD4A2K4.
TreeFamiTF329218.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiD4A2K4.

Gene expression databases

BgeeiENSRNOG00000003334.
GenevisibleiD4A2K4. RN.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH21_RAT
AccessioniPrimary (citable) accession number: D4A2K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.