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Protein

Serine/threonine-protein kinase

Gene

Prkd3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by DAG and phorbol esters.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei605ATPUniRule annotation1
Active sitei699Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi582 – 590ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1660661 Sphingolipid de novo biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinaseUniRule annotation (EC:2.7.11.13UniRule annotation)
Gene namesi
Name:Prkd3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1310236 Prkd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiD4A229
PeptideAtlasiD4A229
PRIDEiD4A229

Expressioni

Gene expression databases

BgeeiENSRNOG00000005289
ExpressionAtlasiD4A229 baseline and differential
GenevisibleiD4A229 RN

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Vamp2P630452EBI-1255458,EBI-520880

Protein-protein interaction databases

IntActiD4A229, 1 interactor
STRINGi10116.ENSRNOP00000007491

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 204Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini271 – 321Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini416 – 532PHInterPro annotationAdd BLAST117
Domaini576 – 832Protein kinaseInterPro annotationAdd BLAST257

Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.UniRule annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG4236 Eukaryota
ENOG410XQZ3 LUCA
GeneTreeiENSGT00910000144054
InParanoidiD4A229
KOiK06070
OMAiGRPTICQ
OrthoDBiEOG091G02RG
TreeFamiTF314320

Family and domain databases

CDDicd00029 C1, 2 hits
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR015727 Protein_Kinase_C_mu-related
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR22968 PTHR22968, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PIRSFiPIRSF000552 PKC_mu_nu_D2, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00233 PH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

D4A229-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANNSPPSA QKSVFPATVS AVLPTPSPCS SPKTGLSARL SNGSFSAASL
60 70 80 90 100
TNSRGSVHTV SFLLQIGLTR ESVTIEAQEL SLSAVKDLVC SIVYQKFPEC
110 120 130 140 150
GFFGMYDKIL LFRHNMNSEN ILQLITSADE IHEGDLVEVV LSALATVEDF
160 170 180 190 200
QIRPHALYVH SYKAPTFCDY CGEMLWGLVR QGLKCEGCGL NYHKRCAFKI
210 220 230 240 250
PNNCSGVRKR RLSNVSLPGP GLSVPRPLQP ECVPLLSEES HTHQEPSKRI
260 270 280 290 300
PSWSGRPIWM EKMVMCRVKV PHTFAVHSYG RPTICQYCKR LLKGLFRQGL
310 320 330 340 350
QCKDCKFNCH KRCASKVPRD CLGEVTFNGE PSSVGTDTDM PMDIDSNDVN
360 370 380 390 400
SDGSRGLDDS EEPSPPEDKM FFLDAADLDV ERDEEPVKTI SPSTSNNIPL
410 420 430 440 450
MRVVQSIKHT KRKSSTVVKE GWMVHYTSRD NLRKRHYWRL DSKCLTLFQN
460 470 480 490 500
ESGSKYYKEI PLSEILRISS PQDFTSISQG SNPHCFEIIT DTVVYFVGEN
510 520 530 540 550
NGNSTHNPVL AATGVGLDVA QSWEKAIRQA LMPVTPQASV CTSPGQGKDH
560 570 580 590 600
KDLATSISVS NCQIQENVDI SSVYQIFADE VLGSGQFGIV YGGKHRKTGR
610 620 630 640 650
DVAIKVIDKM RFPTKQESQL RNEVAILQNL HHPGIVNLEC MFETPERVFV
660 670 680 690 700
VMEKLHGDML EMILSSEKSR LPERITKFMV TQILVALRNL HFKNIVHCDL
710 720 730 740 750
KPENVLLASA EPFPQVKLCD FGFARIIGEK SFRRSVVGTP AYLAPEVLRS
760 770 780 790 800
KGYNRSLDMW SVGVIVYVSL SGTFPFNEDE DINDQIQNAA FMYPPNPWRE
810 820 830 840 850
ISSEAIDLIN NLLQVKMRKR YSVDKSLSHP WLQDYQTWLD LREFETRIGE
860 870 880 890
RYITHESDDA RWEIHAYTHN LEYPKHFIMA PNPDDMEEGP
Length:890
Mass (Da):100,156
Last modified:April 20, 2010 - v1
Checksum:iEB8BA70DF389659A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07062647 Genomic DNA No translation available.
RefSeqiNP_001019434.2, NM_001024263.2
XP_006239690.1, XM_006239628.3
XP_006239691.1, XM_006239629.3
XP_008762643.1, XM_008764421.1
UniGeneiRn.3990

Genome annotation databases

EnsembliENSRNOT00000007492; ENSRNOP00000007491; ENSRNOG00000005289
GeneIDi313834
KEGGirno:313834

Similar proteinsi

Entry informationi

Entry nameiD4A229_RAT
AccessioniPrimary (citable) accession number: D4A229
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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