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Protein
Submitted name:

Microsomal triglyceride transfer protein

Gene

Mttp

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • lipid transporter activity Source: RGD

GO - Biological processi

  • cholesterol homeostasis Source: RGD
  • circadian rhythm Source: Ensembl
  • lipid transport Source: RGD
  • lipoprotein metabolic process Source: RGD
  • lipoprotein transport Source: Ensembl
  • protein lipidation Source: Ensembl
  • response to calcium ion Source: RGD
  • triglyceride metabolic process Source: Ensembl

Enzyme and pathway databases

ReactomeiR-RNO-8866423 VLDL assembly
R-RNO-8963888 Chylomicron assembly

Chemistry databases

SwissLipidsiSLP:000000410

Names & Taxonomyi

Protein namesi
Submitted name:
Microsomal triglyceride transfer proteinImported
Gene namesi
Name:MttpImported
ORF Names:rCG_28903Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1308388 Mttp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501408780422 – 896Sequence analysisAdd BLAST875

Proteomic databases

PeptideAtlasiD4A1W8
PRIDEiD4A1W8

Expressioni

Gene expression databases

BgeeiENSRNOG00000010655

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014630

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 659VitellogeninInterPro annotationAdd BLAST632

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4337 Eukaryota
ENOG410YKCW LUCA
GeneTreeiENSGT00390000011412
KOiK14463
OMAiEMNKYML
OrthoDBiEOG091G0BRK
TreeFamiTF328754

Family and domain databases

Gene3Di1.25.10.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
PfamiView protein in Pfam
PF01347 Vitellogenin_N, 1 hit
SMARTiView protein in SMART
SM00638 LPD_N, 1 hit
SUPFAMiSSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 1 hit
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit

Sequencei

Sequence statusi: Complete.

D4A1W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLAVLFLC FFSSYSASVK GHTTGLSLNN ERLYKLTYST EVFLDGGKGK
60 70 80 90 100
LQDSVGYRIS SDVDVVLLWR NPDGDDDQLI QVTITAVNVE NAGQQRGEKS
110 120 130 140 150
IFKGKSTPKI VGKDNLEALR RPMLLHLVRG KVKEFYSYEN EPVGIENLKR
160 170 180 190 200
GLASLFQMQL TSGTTNEVDI SGDCKVTYQA QQDKVVKIKA LDTCKIERSG
210 220 230 240 250
FTTANQVLGV TSKATSVTTY KIEDSFVTAV VAEETRAFAL NFLQTVAGKI
260 270 280 290 300
VSKQKLELKT TEAGPRMVPG KQVAGVIKAI DSKYKAIPIV GQVLQSVCKG
310 320 330 340 350
CPSLAEHWQS IRKHLEPENL SNAEAVQSFL AFIQHLRTSR REEILQILKA
360 370 380 390 400
EKKEVLPQLV DAVTSAQTPA SLEAILDFLD FKSDSSIILQ ERFLYACGFA
410 420 430 440 450
SHPDEELLQA LLSKFKGSFA SNDIRESVMI IIGALVRKLC QNEGCKLKAV
460 470 480 490 500
VEAKKLILGG LEKPEKKEDT TMYLLALKNA LLPEGIPLLL KYAEAGEGPV
510 520 530 540 550
SHLATTVLQR YDASFITDEV KKTLNRIYHQ NRKVHEKTVR TTAAAVILKN
560 570 580 590 600
NPSYMDVKNI LLSIGELPKE MNKYMLTIVQ DILHFEMPAS KMIRRVLKEM
610 620 630 640 650
IVHNYDRFSK SGSSSAYTGY VERSPHAAST YSLDILYSGS GILRRSNLNI
660 670 680 690 700
FQYIGKAELH GSQVVIEAQG LEGLIAATPD EGEENLDSYA GMSAILFDVQ
710 720 730 740 750
LRPVTFFNGY SDLMSKMLSA SGDPVSVVKG LILLIDHSQD IQLQSGLKAN
760 770 780 790 800
MDIQGGLAID ISGSMEFSLW YRESKTRVKN RVAVVITSDI TVDSSFVKAG
810 820 830 840 850
LESRAETEAG LEFISTVQFS QYPFLVCMQM DKAEAPLRQF ETKYERLSTG
860 870 880 890
RGYVSRRRKE SLVPGCELPL HQENSEMCNV VFPPQPESGN SGGGWF
Length:896
Mass (Da):99,187
Last modified:April 20, 2010 - v1
Checksum:iB815F841AA9C3588
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07013550 Genomic DNA No translation available.
AABR07013551 Genomic DNA No translation available.
CH473952 Genomic DNA Translation: EDL82305.1
RefSeqiNP_001101197.1, NM_001107727.1
UniGeneiRn.81556

Genome annotation databases

EnsembliENSRNOT00000014631; ENSRNOP00000014630; ENSRNOG00000010655
GeneIDi310900
KEGGirno:310900

Similar proteinsi

Entry informationi

Entry nameiD4A1W8_RAT
AccessioniPrimary (citable) accession number: D4A1W8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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