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Protein

3-hydroxybutyrate dehydrogenase type 2

Gene

Bdh2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).By similarity

Catalytic activityi

(R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH.

Pathwayi: Siderophore biosynthesis

This protein is involved in Siderophore biosynthesis.
View all proteins of this organism that are known to be involved in Siderophore biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei58 – 581NADBy similarity
Binding sitei144 – 1441SubstrateBy similarity
Active sitei147 – 1471Proton acceptorPROSITE-ProRule annotation
Binding sitei151 – 1511NADBy similarity
Binding sitei188 – 1881SubstrateBy similarity
Binding sitei205 – 2051SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 3728NADBy similarityAdd
BLAST
Nucleotide bindingi180 – 1845NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6299-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxybutyrate dehydrogenase type 2 (EC:1.1.1.-, EC:1.1.1.30)
Alternative name(s):
Dehydrogenase/reductase SDR family member 6
R-beta-hydroxybutyrate dehydrogenase
Gene namesi
Name:Bdh2
Synonyms:Dhrs6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309898. Bdh2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2452453-hydroxybutyrate dehydrogenase type 2PRO_0000398628Add
BLAST

Proteomic databases

PaxDbiD4A1J4.
PRIDEiD4A1J4.

PTM databases

iPTMnetiD4A1J4.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019507.

Structurei

3D structure databases

ProteinModelPortaliD4A1J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
InParanoidiD4A1J4.
KOiK00019.
OrthoDBiEOG7W154W.
PhylomeDBiD4A1J4.
TreeFamiTF328795.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A1J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRLEGKVIV LTAAAQGIGR ASALAFAREG AKVIATDINE AKLQELENYP
60 70 80 90 100
GIQTRVLDVT KKRQIDQFAS EIEKIDVLFN VAGFVHHGTI LDCEEKDWDF
110 120 130 140 150
SMNLNVRSMY LMIKAFLPKM LAQKSGNIIN MSSVASSIKG VENRCVYSAT
160 170 180 190 200
KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARDDPKEALK
210 220 230 240
AFLNRQKTGR FASAEEVALL CVYLASDESA YVTGTPVVID GGWSL
Length:245
Mass (Da):26,651
Last modified:October 5, 2010 - v2
Checksum:i46E513E8F8CF1169
GO

Sequence cautioni

The sequence EDL82248.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473952 Genomic DNA. Translation: EDL82248.1. Different initiation.
RefSeqiNP_001099943.1. NM_001106473.1.
XP_006233384.1. XM_006233322.2.
UniGeneiRn.3651.

Genome annotation databases

GeneIDi295458.
KEGGirno:295458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473952 Genomic DNA. Translation: EDL82248.1. Different initiation.
RefSeqiNP_001099943.1. NM_001106473.1.
XP_006233384.1. XM_006233322.2.
UniGeneiRn.3651.

3D structure databases

ProteinModelPortaliD4A1J4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019507.

PTM databases

iPTMnetiD4A1J4.

Proteomic databases

PaxDbiD4A1J4.
PRIDEiD4A1J4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi295458.
KEGGirno:295458.

Organism-specific databases

CTDi56898.
RGDi1309898. Bdh2.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
InParanoidiD4A1J4.
KOiK00019.
OrthoDBiEOG7W154W.
PhylomeDBiD4A1J4.
TreeFamiTF328795.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6299-MONOMER.

Miscellaneous databases

PROiD4A1J4.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiBDH2_RAT
AccessioniPrimary (citable) accession number: D4A1J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: June 8, 2016
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.