ID   D4A1F4_RAT              Unreviewed;       584 AA.
AC   D4A1F4;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 98.
DE   SubName: Full=Intracisternal A particle-promoted polypeptide {ECO:0000313|Ensembl:ENSRNOP00000021850.4};
GN   Name=Ipp {ECO:0000313|Ensembl:ENSRNOP00000021850.4,
GN   ECO:0000313|RGD:1306299};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000021850.4, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000021850.4, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000021850.4,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000021850.4}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000021850.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; NP_001100149.2; NM_001106679.2.
DR   RefSeq; XP_006238702.1; XM_006238640.3.
DR   RefSeq; XP_006238704.1; XM_006238642.3.
DR   RefSeq; XP_008762214.1; XM_008763992.2.
DR   RefSeq; XP_017448764.1; XM_017593275.1.
DR   AlphaFoldDB; D4A1F4; -.
DR   SMR; D4A1F4; -.
DR   STRING; 10116.ENSRNOP00000021850; -.
DR   PaxDb; 10116-ENSRNOP00000021850; -.
DR   PeptideAtlas; D4A1F4; -.
DR   Ensembl; ENSRNOT00000021850.6; ENSRNOP00000021850.4; ENSRNOG00000016183.8.
DR   GeneID; 298439; -.
DR   KEGG; rno:298439; -.
DR   AGR; RGD:1306299; -.
DR   CTD; 3652; -.
DR   RGD; 1306299; Ipp.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000158629; -.
DR   InParanoid; D4A1F4; -.
DR   OMA; CYDPRDN; -.
DR   OrthoDB; 5472491at2759; -.
DR   TreeFam; TF329218; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000016183; Expressed in adult mammalian kidney and 19 other cell types or tissues.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   CDD; cd18466; BACK_KLHL27_IPP; 1.
DR   CDD; cd18256; BTB_POZ_KLHL27_IPP; 1.
DR   Gene3D; 1.25.40.420; -; 1.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR030104; BTB_POZ_IPP.
DR   InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR   InterPro; IPR047067; IPP_BACK.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR45632:SF13; KELCH-LIKE PROTEIN 26; 1.
DR   PANTHER; PTHR45632; LD33804P; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 5.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ   SEQUENCE   584 AA;  65291 MW;  4DE28395A7A926CE CRC64;
     MSKEEYAKAA DSSFSSDKHA QLILAQMNKM RTGQHFCDVQ LQVGKETFQV HRLVLAASSP
     YFAALFTGGM KESSKDVVQI LGVEAGIFQL LLDFIYTGLV NIAVSNVQEL IVAADMLQLT
     EVVNLCCDFL KGQIDPQNCI GLFQFSEQIA CHDLLEFTEN YIHVHFLEVH SGEEFLALTK
     DQLIRILRSE ELSIEDEYQV FLAAMQWILK DLGKRRKHVV EVLDPVRFPL LPSQRLLKYI
     EGVSDFNLRV ALQTLLKEYC EVCKSPKENK FCSFLQTSKA RPRKKARKYL YAVGGYTRLQ
     GGRWSDSRAL SCVERFDTFS QYWTTVSSLH QARCGLGVAV LGGMVYAIGG EKDSMIFDCT
     ECYDPVTKQW TTVASMNHPR CGLGVCVCYG AIYALGGWVG AEIGDTIERF DPDENKWEVV
     GNMAVSRYYF GCCEMQGLIY AVGGISNEGL ELRSFEVYDP LSKRWSPLPP MGTRRAYLGV
     AALNDCIYAI GGWNETQDAL HTVEKYSFEE EKWIEVASMK VPRAGMCVVA VNGLLYVSGG
     RSSSHDFLAP GTLDSVEVYN PHSDTWTEIG NMITSRCEGG VAVL
//