ID D4A197_RAT Unreviewed; 190 AA. AC D4A197; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 2. DT 27-MAR-2024, entry version 94. DE SubName: Full=Methylmalonyl CoA epimerase {ECO:0000313|Ensembl:ENSRNOP00000021884.6}; GN Name=Mcee {ECO:0000313|Ensembl:ENSRNOP00000021884.6, GN ECO:0000313|RGD:1309966}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000021884.6, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000021884.6, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000021884.6, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000021884.6} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000021884.6}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the methylmalonyl-CoA epimerase family. CC {ECO:0000256|ARBA:ARBA00009308}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_017444518.1; XM_017589029.1. DR AlphaFoldDB; D4A197; -. DR STRING; 10116.ENSRNOP00000021884; -. DR PhosphoSitePlus; D4A197; -. DR PaxDb; 10116-ENSRNOP00000021884; -. DR PeptideAtlas; D4A197; -. DR Ensembl; ENSRNOT00000021884.7; ENSRNOP00000021884.6; ENSRNOG00000016327.7. DR GeneID; 293829; -. DR UCSC; RGD:1309966; rat. DR AGR; RGD:1309966; -. DR CTD; 84693; -. DR RGD; 1309966; Mcee. DR VEuPathDB; HostDB:ENSRNOG00000016327; -. DR eggNOG; KOG2944; Eukaryota. DR GeneTree; ENSGT00940000153941; -. DR HOGENOM; CLU_046006_5_0_1; -. DR InParanoid; D4A197; -. DR OrthoDB; 306061at2759; -. DR TreeFam; TF313417; -. DR Reactome; R-RNO-71032; Propionyl-CoA catabolism. DR Proteomes; UP000002494; Chromosome 1. DR Bgee; ENSRNOG00000016327; Expressed in heart and 20 other cell types or tissues. DR GO; GO:0004493; F:methylmalonyl-CoA epimerase activity; ISO:RGD. DR GO; GO:0046491; P:L-methylmalonyl-CoA metabolic process; ISO:RGD. DR CDD; cd07249; MMCE; 1. DR Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 1. DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase. DR InterPro; IPR017515; MeMalonyl-CoA_epimerase. DR InterPro; IPR037523; VOC. DR NCBIfam; TIGR03081; metmalonyl_epim; 1. DR PANTHER; PTHR43048; METHYLMALONYL-COA EPIMERASE; 1. DR PANTHER; PTHR43048:SF3; METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL; 1. DR Pfam; PF13669; Glyoxalase_4; 1. DR SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 1. DR PROSITE; PS51819; VOC; 1. PE 3: Inferred from homology; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. FT DOMAIN 61..190 FT /note="VOC" FT /evidence="ECO:0000259|PROSITE:PS51819" SQ SEQUENCE 190 AA; 20165 MW; 1B56A766ADE71C13 CRC64; MRLVVKAAAL AAGATELGTE PRALRLLGLF SRVQTPVAAG RSFSTSPSQH QASSPVWKLG RLNHVAIAVP DLEKASSFYR DVLGAQVSEA VPLPEHGVSV VFVNLGNTKM ELLHPLGSDS PIAGFLQKNK AGGMHHVCIE VDNINAAVMD LKKQKIRSLS DEAKIGAHGK PVIFLHPKDC GGVLVELEQA //