ID   D4A106_RAT              Unreviewed;       937 AA.
AC   D4A106;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   27-MAR-2024, entry version 103.
DE   SubName: Full=WD repeat domain 3 {ECO:0000313|Ensembl:ENSRNOP00000026726.5};
GN   Name=Wdr3 {ECO:0000313|Ensembl:ENSRNOP00000026726.5,
GN   ECO:0000313|RGD:1307480};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000026726.5, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000026726.5, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000026726.5,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000026726.5}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000026726.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR3/UTP12 family.
CC       {ECO:0000256|ARBA:ARBA00038229}.
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DR   AlphaFoldDB; D4A106; -.
DR   STRING; 10116.ENSRNOP00000026726; -.
DR   iPTMnet; D4A106; -.
DR   PhosphoSitePlus; D4A106; -.
DR   PaxDb; 10116-ENSRNOP00000026726; -.
DR   PeptideAtlas; D4A106; -.
DR   Ensembl; ENSRNOT00000026726.8; ENSRNOP00000026726.5; ENSRNOG00000019670.8.
DR   AGR; RGD:1307480; -.
DR   RGD; 1307480; Wdr3.
DR   VEuPathDB; HostDB:ENSRNOG00000019670; -.
DR   eggNOG; KOG0306; Eukaryota.
DR   GeneTree; ENSGT00940000153859; -.
DR   HOGENOM; CLU_005318_0_1_1; -.
DR   InParanoid; D4A106; -.
DR   OMA; MQCLRTV; -.
DR   OrthoDB; 168440at2759; -.
DR   TreeFam; TF300427; -.
DR   Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000019670; Expressed in skeletal muscle tissue and 20 other cell types or tissues.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; ISO:RGD.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; IBA:GO_Central.
DR   GO; GO:0042274; P:ribosomal small subunit biogenesis; ISO:RGD.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR007148; SSU_processome_Utp12.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR19853; WD REPEAT CONTAINING PROTEIN 3 WDR3; 1.
DR   PANTHER; PTHR19853:SF0; WD REPEAT-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF04003; Utp12; 1.
DR   Pfam; PF00400; WD40; 10.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 11.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF69304; Tricorn protease N-terminal domain; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 8.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 7.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT   DOMAIN          812..901
FT                   /note="Small-subunit processome Utp12"
FT                   /evidence="ECO:0000259|Pfam:PF04003"
FT   REGION          231..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   937 AA;  105479 MW;  990BB3A62268E6A5 CRC64;
     MGLTKQYLRY VASAVFGLIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW DLRKGEKILI
     LQGLKQEVTC LCPSPDGLHL AVGYEDGAIR VFSLLSGEGN ITFNGHRAAV TSLKYDQLGG
     RLASGSKDTD VIIWDVINES GLYRLKGHKD AVTQALFLRE RNLLVTSGKD TMVKWWDLDN
     QHCFKTMVGH RTEVWGLVLV SEETRLITGA ADSELRAWDI AYLQEIDDPE EPEPKKIKEC
     PGIQDTPEAE DRTLEADDEK SEDRILSCRK AGSLMREGRD RVVNLAVDKT GRILACHGTD
     SVLEVFCILS KAEVQKKMDK KLKKARKKAR LNSANEEEDP ETSVSMTLQD EILRVTKIKT
     SAKIKSFDLI HSPQGELKAV FLLQNNLVEL YSLSTSLPNP QPVRTSRITI GGHRSDVRTL
     SFSSDNIAVL SAAAESVKIW NRSTLQCIRT MPCEYALCSF FVPGDRQVVI GTKTGNMQLY
     DLASGNLLET IAAHDGALWS MSLSPDQRGF VTGGADKAVK FWDFELVTDK NSTQKRLSVK
     QTRILQLDED VLYVCYSPDQ RLLAVSLLDC TVKIFYVDTL KFFLSLYGHK LPVICMDISH
     DGALIATGSA DRNVKIWGLD FGDCHRSLFA HDDSVMHLRF VPKSHLFFTA GKDHKIKQWD
     ADKFEHIQTL EGHHQEIWCL AVSPSGDYVV SASHDKSLRL WERTREPLIL EEERELQREA
     EYEESVAKEE QPAVPGETQG DNYFTGKKTI ETVKAAERIM EAIELYREET AKMKEHRAIC
     RAAGKEVPLP VNPILMAHGN ISVSGILLFL LSELEEALLV LPFSYVPDIL TLFNGFIQTG
     SDVELLCRCL FFLLRIHFGQ ITSNQMLVPV IEKLKETTIS KVRQVQDVIG FNMAGLNYLK
     RECEAKSEVM FFAEATSHLE EKKRKRKNRR KMILTLT
//