ID   D4A0R1_RAT              Unreviewed;      1151 AA.
AC   D4A0R1;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 4.
DT   27-MAR-2024, entry version 102.
DE   SubName: Full=Zinc finger protein, multitype 2 {ECO:0000313|Ensembl:ENSRNOP00000035072.7};
GN   Name=Zfpm2 {ECO:0000313|Ensembl:ENSRNOP00000035072.7,
GN   ECO:0000313|RGD:1306021};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000035072.7, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000035072.7, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000035072.7,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000035072.7}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000035072.7};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; NP_001123973.1; NM_001130501.1.
DR   AlphaFoldDB; D4A0R1; -.
DR   STRING; 10116.ENSRNOP00000035072; -.
DR   PhosphoSitePlus; D4A0R1; -.
DR   PaxDb; 10116-ENSRNOP00000035072; -.
DR   Ensembl; ENSRNOT00000029419.7; ENSRNOP00000035072.7; ENSRNOG00000004109.8.
DR   GeneID; 314930; -.
DR   KEGG; rno:314930; -.
DR   UCSC; RGD:1306021; rat.
DR   AGR; RGD:1306021; -.
DR   CTD; 23414; -.
DR   RGD; 1306021; Zfpm2.
DR   VEuPathDB; HostDB:ENSRNOG00000004109; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00530000063823; -.
DR   HOGENOM; CLU_010755_0_0_1; -.
DR   OMA; QISSICP; -.
DR   TreeFam; TF331342; -.
DR   Reactome; R-RNO-983231; Factors involved in megakaryocyte development and platelet production.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000004109; Expressed in cerebellum and 16 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0001673; C:male germ cell nucleus; ISO:RGD.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:RGD.
DR   GO; GO:0003713; F:transcription coactivator activity; ISO:RGD.
DR   GO; GO:0003714; F:transcription corepressor activity; ISO:RGD.
DR   GO; GO:0048738; P:cardiac muscle tissue development; ISO:RGD.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0048568; P:embryonic organ development; ISO:RGD.
DR   GO; GO:0045444; P:fat cell differentiation; ISO:RGD.
DR   GO; GO:0007507; P:heart development; ISO:RGD.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   GO; GO:0030324; P:lung development; ISO:RGD.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISO:RGD.
DR   GO; GO:0045599; P:negative regulation of fat cell differentiation; ISO:RGD.
DR   GO; GO:2000195; P:negative regulation of female gonad development; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0003148; P:outflow tract septum morphogenesis; ISO:RGD.
DR   GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; ISO:RGD.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISO:RGD.
DR   GO; GO:2000020; P:positive regulation of male gonad development; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0003221; P:right ventricular cardiac muscle tissue morphogenesis; ISO:RGD.
DR   GO; GO:0001570; P:vasculogenesis; ISO:RGD.
DR   GO; GO:0060412; P:ventricular septum morphogenesis; ISO:RGD.
DR   CDD; cd19216; PR-SET_ZFPM2; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR   InterPro; IPR039746; FOG.
DR   InterPro; IPR034731; ZF_CCHC_FOG.
DR   InterPro; IPR049361; ZFPM1/2_PR.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR12958; FRIEND OF GATA2-RELATED; 1.
DR   PANTHER; PTHR12958:SF5; ZINC FINGER PROTEIN ZFPM2; 1.
DR   Pfam; PF21182; FOG1-like_PR; 1.
DR   Pfam; PF12874; zf-met; 1.
DR   SMART; SM00355; ZnF_C2H2; 8.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR   PROSITE; PS51810; ZF_CCHC_FOG; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
DR   Genevisible; D4A0R1; RN.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ   SEQUENCE   1151 AA;  127805 MW;  F6DCC5F568FD66AF CRC64;
     MSRRKQSKPR QIKRPLEDAI EDEEEECPVE EADVIAKGDF PLEESFPTGF ESENLSCEEV
     EFFCNKGDDE GIQEPAESDG DSHSDKPGQP GVETDDWDGP GELEVFQRDG ERKIQSRQQL
     PVGTTWGPFA GKMDLNNNSL KTKAQVSMVL TAGPKWLLDV TWQGVEDSKN NCIVYSKGGQ
     LWCTTTKAIS EGEELIAFVV DFDSRLQTAS QMTLTEGMYP ARLLDSIQLL PQQAAMASIL
     PTAIVNKDIF PCKSCGIWYR SERNLQAHLM YYCSGRQREA APVSEENEDS THQISSLCPF
     PQCTKSFSNA RALEMHLTSH SGVKMEEFLP PGASLKCTVC SYTADSVINF HQHLFSHLTQ
     AAFRCNHCHF GFQTQRELLQ HQELHVPGGK LPRESDMEHS PSGTEDSLQP ATDLLARSDL
     SQSQKAMPTK DASSDTELDK CEKKTQLFLT NQRPEMQPAA NKQNFSYTKI KSEPSSPRLA
     SSPVQPNLGP SFPVGPFLSQ FAFPQDITMV PQASEILAKM SELVHRRLRH GSSSYPPVIY
     SPLMPKGATC FECNITFNNL DNYLVHKKHY CSSRWQQMAK SPEFPSVSEK IPEALSPNTG
     QTSINLLNPA AHPPDPENPL LQTSCINSST VLDLIGPNGK GHEKDFSTQA KKLPTSNNND
     DKINGKPVDV KNPSGPLVDG ESDPNKTTCE ACNITFSRHE TYMVHKQYYC ATRHDPPLKR
     SASNKVPAMQ RTMRTRKRRK MYEMCLPEQE QRPPLVQQRF LDVANLSNPC SSTQEPTEGL
     GECYHPRCDI FPGIVSKHLE TSLAINKCVP VPKCDTTHSS VSCLEMDVPI DLSKKCLSQS
     ERTTASPKRL LDYHECTVCK ISFNKVENYL AHKQNFCPVT AHQRNDLGQL DGKVFPNPES
     ERNSPEVSFE RNMIKCEKNG NPKQPSPNGN LFSSHLATLQ GLKVFSEAAQ LIATKEENKH
     LFLPQCLYPG AIKKTKGADQ LSPYYGIKPS DYIAGSLVIH NTDVEQNTNT ENESPKGQAS
     SNGCAVPKKD SLPLLPKNRG MVIVNGGLKQ DERPTANPQQ ENISQNAQHE DGHKSPSWIS
     ENPLAANENV SPGIPCAEEQ LSSIAKGVNG STQAPSSGKY CRLCDIQFNN LSNFITHKKF
     YCSSHAAEHV K
//