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Protein

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Gene

Wdr4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the formation of N7-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processtRNA processingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4UniRule annotation
Alternative name(s):
WD repeat-containing protein 4UniRule annotation
Gene namesi
Name:Wdr4Imported
Synonyms:WDR4UniRule annotation
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1585179 Wdr4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiD4A0Q3
PeptideAtlasiD4A0Q3

Expressioni

Gene expression databases

BgeeiENSRNOG00000001181
GenevisibleiD4A0Q3 RN

Interactioni

Subunit structurei

Forms a heterodimer with the catalytic subunit METTL1.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059024

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 271WD_REPEATS_REGIONInterPro annotationAdd BLAST86
Repeati229 – 271WDPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the WD repeat TRM82 family.UniRule annotation

Keywords - Domaini

RepeatUniRule annotation, WD repeatUniRule annotation

Phylogenomic databases

eggNOGiKOG3914 Eukaryota
ENOG4111WRP LUCA
GeneTreeiENSGT00390000012174
InParanoidiD4A0Q3
OMAiCQENCVA
OrthoDBiEOG091G0C2L

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03056 TRM82, 1 hit
InterProiView protein in InterPro
IPR028884 Trm82
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR16288 PTHR16288, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 2 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

D4A0Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLPVRMLL PRTPFARCRV TSLAGATRKG AERRTCAEAA DGPMASSAGL
60 70 80 90 100
ALCAQTLVVR GGSRFLAFST ASSDDDCLFS YDCSTAEKKS VQEDKGEDGQ
110 120 130 140 150
PADRGSDTIL ASTFSKSGRY FALTDDSKRL ILFRTKPWQC LSVRTVVRRC
160 170 180 190 200
TALTFTASED RVLVADKSGD VYSFPVLDSG GCGRLELGHL SMLLDVAVSP
210 220 230 240 250
DDQFVLTADR DEKIRVSWAA APHSIEAFCL GHTEFVSRIF VVPSHPELLL
260 270 280 290 300
SSSGDGTLRL WKYRSGCQLQ CCDLASLQEP GEHSVHKGLA ASRIAFWGRE
310 320 330 340 350
SYVVLLCECV PVGFVFQLDA SRQQLVFRQR LTFPHRVWDV VFEETRGLWV
360 370 380 390 400
LQDCRDAPLA LWRPMGSEWQ AAPDDAVSQR LCSHLRESWA MLEGSAGADD
410 420 430 440 450
GFRSLYKATF DNMTSYLKKK EERLKQQLKK KRQRSPHPGS PEQTKKACPA

RAVSP
Length:455
Mass (Da):50,443
Last modified:July 22, 2015 - v2
Checksum:iC5FDC2EAE6EA8896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072818 Genomic DNA No translation available.
RefSeqiXP_008771050.1, XM_008772828.2
UniGeneiRn.116634

Genome annotation databases

EnsembliENSRNOT00000068289; ENSRNOP00000059024; ENSRNOG00000001181
GeneIDi690032
UCSCiRGD:1585179 rat

Similar proteinsi

Entry informationi

Entry nameiD4A0Q3_RAT
AccessioniPrimary (citable) accession number: D4A0Q3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: March 28, 2018
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health