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D4A0Q3

- D4A0Q3_RAT

UniProt

D4A0Q3 - D4A0Q3_RAT

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Protein

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Wdr4

Gene

Wdr4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

tRNA processingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Wdr4UniRule annotation
Alternative name(s):
WD repeat-containing protein 4UniRule annotation
Gene namesi
Name:Wdr4UniRule annotationImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi1585179. Wdr4.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Subunit structurei

Forms a heterodimer with the catalytic subunit METTL1.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD4A0Q3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati61 – 10040WD 1UniRule annotationAdd
BLAST
Repeati102 – 14140WD 2UniRule annotationAdd
BLAST
Repeati145 – 18541WD 3UniRule annotationAdd
BLAST
Repeati188 – 22841WD 4UniRule annotationAdd
BLAST
Repeati289 – 32941WD 5UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat TRM82 family.UniRule annotation
Contains 5 WD repeats.UniRule annotation

Keywords - Domaini

RepeatUniRule annotation, WD repeatUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000012174.
InParanoidiD4A0Q3.
KOiK15443.
OMAiWVLQDCR.
OrthoDBiEOG7GXPCK.
PhylomeDBiD4A0Q3.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03056. TRM82.
InterProiIPR028884. Trm82.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A0Q3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASSAGLALC AQTLVVRGGS RFLAFSTASS DDDCLFSYDC STAEKKSVQE
60 70 80 90 100
DKGEDGQPAD RGSDTILAST FSKSGRYFAL TDDSKRLILF RTKPWQCLSV
110 120 130 140 150
RTVVRRCTAL TFTASEDRVL VADKSGDVYS FPVLDSGGCG RLELGHLSML
160 170 180 190 200
LDVAVSPDDQ FVLTADRDEK IRVSWAAAPH SIEAFCLGHT EFVSRIFVVP
210 220 230 240 250
SHPELLLSSS GDGTLRLWKY RSGCQLQCCD LASLQEPGEH SVHKGLAASR
260 270 280 290 300
IAFWGRESYV VLLCECVPVG FVFQLDASRQ QLVFRQRLTF PHRVWDVVFE
310 320 330 340 350
ETRGLWVLQD CRDAPLALWR PMGSEWQAAP DDAVSQRLCS HLRESWALLV
360
QMMASAACTR PPLTT
Length:365
Mass (Da):40,360
Last modified:April 20, 2010 - v1
Checksum:i1664842BEC2C5DB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06100136 Genomic DNA. No translation available.
RefSeqiNP_001129139.1. NM_001135667.1.
UniGeneiRn.116634.

Genome annotation databases

EnsembliENSRNOT00000068289; ENSRNOP00000059024; ENSRNOG00000001181.
GeneIDi690032.
KEGGirno:690032.
UCSCiRGD:1585179. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06100136 Genomic DNA. No translation available.
RefSeqi NP_001129139.1. NM_001135667.1.
UniGenei Rn.116634.

3D structure databases

ProteinModelPortali D4A0Q3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000068289 ; ENSRNOP00000059024 ; ENSRNOG00000001181 .
GeneIDi 690032.
KEGGi rno:690032.
UCSCi RGD:1585179. rat.

Organism-specific databases

CTDi 10785.
RGDi 1585179. Wdr4.

Phylogenomic databases

GeneTreei ENSGT00390000012174.
InParanoidi D4A0Q3.
KOi K15443.
OMAi WVLQDCR.
OrthoDBi EOG7GXPCK.
PhylomeDBi D4A0Q3.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Miscellaneous databases

NextBioi 740037.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
HAMAPi MF_03056. TRM82.
InterProi IPR028884. Trm82.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00320. WD40. 2 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4A0Q3_RAT
AccessioniPrimary (citable) accession number: D4A0Q3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3