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D4A0Q3 (D4A0Q3_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Wdr4 HAMAP-Rule MF_03056
Alternative name(s):
WD repeat-containing protein 4 HAMAP-Rule MF_03056
Gene names
Name:Wdr4 HAMAP-Rule MF_03056 Ensembl ENSRNOP00000059024 RGD 1585179
OrganismRattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000059024
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit By similarity. HAMAP-Rule MF_03056

Pathway

tRNA modification; N(7)-methylguanine-tRNA biosynthesis. HAMAP-Rule MF_03056

Subunit structure

Forms a heterodimer with the catalytic subunit METTL1 By similarity. HAMAP-Rule MF_03056

Subcellular location

Nucleus By similarity HAMAP-Rule MF_03056.

Sequence similarities

Belongs to the WD repeat TRM82 family. HAMAP-Rule MF_03056

Contains 5 WD repeats. HAMAP-Rule MF_03056

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSRNOP00000059024

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Repeat61 – 10040WD 1 By similarity HAMAP-Rule MF_03056
Repeat102 – 14140WD 2 By similarity HAMAP-Rule MF_03056
Repeat145 – 18541WD 3 By similarity HAMAP-Rule MF_03056
Repeat188 – 22841WD 4 By similarity HAMAP-Rule MF_03056
Repeat289 – 32941WD 5 By similarity HAMAP-Rule MF_03056

Sequences

Sequence LengthMass (Da)Tools
D4A0Q3 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: 1664842BEC2C5DB1

FASTA36540,360
        10         20         30         40         50         60 
MASSAGLALC AQTLVVRGGS RFLAFSTASS DDDCLFSYDC STAEKKSVQE DKGEDGQPAD 

        70         80         90        100        110        120 
RGSDTILAST FSKSGRYFAL TDDSKRLILF RTKPWQCLSV RTVVRRCTAL TFTASEDRVL 

       130        140        150        160        170        180 
VADKSGDVYS FPVLDSGGCG RLELGHLSML LDVAVSPDDQ FVLTADRDEK IRVSWAAAPH 

       190        200        210        220        230        240 
SIEAFCLGHT EFVSRIFVVP SHPELLLSSS GDGTLRLWKY RSGCQLQCCD LASLQEPGEH 

       250        260        270        280        290        300 
SVHKGLAASR IAFWGRESYV VLLCECVPVG FVFQLDASRQ QLVFRQRLTF PHRVWDVVFE 

       310        320        330        340        350        360 
ETRGLWVLQD CRDAPLALWR PMGSEWQAAP DDAVSQRLCS HLRESWALLV QMMASAACTR 


PPLTT 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000059024.
[2]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000059024.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06100136 Genomic DNA. No translation available.
RefSeqNP_001129139.1. NM_001135667.1.
UniGeneRn.116634.

3D structure databases

ProteinModelPortalD4A0Q3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000068289; ENSRNOP00000059024; ENSRNOG00000001181.
GeneID690032.
KEGGrno:690032.
UCSCRGD:1585179. rat.

Organism-specific databases

CTD10785.
RGD1585179. Wdr4.

Phylogenomic databases

GeneTreeENSGT00390000012174.
KOK15443.
OMAWVLQDCR.
OrthoDBEOG7GXPCK.
PhylomeDBD4A0Q3.

Enzyme and pathway databases

UniPathwayUPA00989.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
HAMAPMF_03056. TRM82.
InterProIPR028884. Trm82.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 2 hits.
[Graphical view]
SMARTSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio740037.

Entry information

Entry nameD4A0Q3_RAT
AccessionPrimary (citable) accession number: D4A0Q3
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)