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D4A0Q3

- D4A0Q3_RAT

UniProt

D4A0Q3 - D4A0Q3_RAT

Protein

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Wdr4

Gene

Wdr4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: Ensembl

    Keywords - Biological processi

    tRNA processingUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Wdr4UniRule annotation
    Alternative name(s):
    WD repeat-containing protein 4UniRule annotation
    Gene namesi
    Name:Wdr4UniRule annotationImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 20

    Organism-specific databases

    RGDi1585179. Wdr4.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleoplasm Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Subunit structurei

    Forms a heterodimer with the catalytic subunit METTL1.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD4A0Q3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati61 – 10040WD 1UniRule annotationAdd
    BLAST
    Repeati102 – 14140WD 2UniRule annotationAdd
    BLAST
    Repeati145 – 18541WD 3UniRule annotationAdd
    BLAST
    Repeati188 – 22841WD 4UniRule annotationAdd
    BLAST
    Repeati289 – 32941WD 5UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat TRM82 family.UniRule annotation
    Contains 5 WD repeats.UniRule annotation

    Keywords - Domaini

    RepeatUniRule annotation, WD repeatUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000012174.
    KOiK15443.
    OMAiWVLQDCR.
    OrthoDBiEOG7GXPCK.
    PhylomeDBiD4A0Q3.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    HAMAPiMF_03056. TRM82.
    InterProiIPR028884. Trm82.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 2 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4A0Q3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSAGLALC AQTLVVRGGS RFLAFSTASS DDDCLFSYDC STAEKKSVQE    50
    DKGEDGQPAD RGSDTILAST FSKSGRYFAL TDDSKRLILF RTKPWQCLSV 100
    RTVVRRCTAL TFTASEDRVL VADKSGDVYS FPVLDSGGCG RLELGHLSML 150
    LDVAVSPDDQ FVLTADRDEK IRVSWAAAPH SIEAFCLGHT EFVSRIFVVP 200
    SHPELLLSSS GDGTLRLWKY RSGCQLQCCD LASLQEPGEH SVHKGLAASR 250
    IAFWGRESYV VLLCECVPVG FVFQLDASRQ QLVFRQRLTF PHRVWDVVFE 300
    ETRGLWVLQD CRDAPLALWR PMGSEWQAAP DDAVSQRLCS HLRESWALLV 350
    QMMASAACTR PPLTT 365
    Length:365
    Mass (Da):40,360
    Last modified:April 20, 2010 - v1
    Checksum:i1664842BEC2C5DB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06100136 Genomic DNA. No translation available.
    RefSeqiNP_001129139.1. NM_001135667.1.
    UniGeneiRn.116634.

    Genome annotation databases

    EnsembliENSRNOT00000068289; ENSRNOP00000059024; ENSRNOG00000001181.
    GeneIDi690032.
    KEGGirno:690032.
    UCSCiRGD:1585179. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06100136 Genomic DNA. No translation available.
    RefSeqi NP_001129139.1. NM_001135667.1.
    UniGenei Rn.116634.

    3D structure databases

    ProteinModelPortali D4A0Q3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000068289 ; ENSRNOP00000059024 ; ENSRNOG00000001181 .
    GeneIDi 690032.
    KEGGi rno:690032.
    UCSCi RGD:1585179. rat.

    Organism-specific databases

    CTDi 10785.
    RGDi 1585179. Wdr4.

    Phylogenomic databases

    GeneTreei ENSGT00390000012174.
    KOi K15443.
    OMAi WVLQDCR.
    OrthoDBi EOG7GXPCK.
    PhylomeDBi D4A0Q3.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .

    Miscellaneous databases

    NextBioi 740037.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    HAMAPi MF_03056. TRM82.
    InterProi IPR028884. Trm82.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD4A0Q3_RAT
    AccessioniPrimary (citable) accession number: D4A0Q3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3