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Protein

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Wdr4

Gene

Wdr4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.UniRule annotation

Pathwayi

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

tRNA processingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Wdr4UniRule annotation
Alternative name(s):
WD repeat-containing protein 4UniRule annotation
Gene namesi
Name:Wdr4UniRule annotationImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1585179. Wdr4.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Subunit structurei

Forms a heterodimer with the catalytic subunit METTL1.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD4A0Q3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati61 – 10040WD 1UniRule annotationAdd
BLAST
Repeati102 – 14140WD 2UniRule annotationAdd
BLAST
Repeati145 – 18541WD 3UniRule annotationAdd
BLAST
Repeati188 – 22841WD 4UniRule annotationAdd
BLAST
Repeati289 – 32941WD 5UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat TRM82 family.UniRule annotation
Contains 5 WD repeats.UniRule annotation

Keywords - Domaini

RepeatUniRule annotation, WD repeatUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000012174.
InParanoidiD4A0Q3.
KOiK15443.
OMAiWVLQDCR.
OrthoDBiEOG7GXPCK.
PhylomeDBiD4A0Q3.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03056. TRM82.
InterProiIPR028884. Trm82.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A0Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSAGLALC AQTLVVRGGS RFLAFSTASS DDDCLFSYDC STAEKKSVQE
60 70 80 90 100
DKGEDGQPAD RGSDTILAST FSKSGRYFAL TDDSKRLILF RTKPWQCLSV
110 120 130 140 150
RTVVRRCTAL TFTASEDRVL VADKSGDVYS FPVLDSGGCG RLELGHLSML
160 170 180 190 200
LDVAVSPDDQ FVLTADRDEK IRVSWAAAPH SIEAFCLGHT EFVSRIFVVP
210 220 230 240 250
SHPELLLSSS GDGTLRLWKY RSGCQLQCCD LASLQEPGEH SVHKGLAASR
260 270 280 290 300
IAFWGRESYV VLLCECVPVG FVFQLDASRQ QLVFRQRLTF PHRVWDVVFE
310 320 330 340 350
ETRGLWVLQD CRDAPLALWR PMGSEWQAAP DDAVSQRLCS HLRESWALLV
360
QMMASAACTR PPLTT
Length:365
Mass (Da):40,360
Last modified:April 20, 2010 - v1
Checksum:i1664842BEC2C5DB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06100136 Genomic DNA. No translation available.
RefSeqiNP_001129139.1. NM_001135667.1.
UniGeneiRn.116634.

Genome annotation databases

EnsembliENSRNOT00000068289; ENSRNOP00000059024; ENSRNOG00000001181.
GeneIDi690032.
KEGGirno:690032.
UCSCiRGD:1585179. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06100136 Genomic DNA. No translation available.
RefSeqiNP_001129139.1. NM_001135667.1.
UniGeneiRn.116634.

3D structure databases

ProteinModelPortaliD4A0Q3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068289; ENSRNOP00000059024; ENSRNOG00000001181.
GeneIDi690032.
KEGGirno:690032.
UCSCiRGD:1585179. rat.

Organism-specific databases

CTDi10785.
RGDi1585179. Wdr4.

Phylogenomic databases

GeneTreeiENSGT00390000012174.
InParanoidiD4A0Q3.
KOiK15443.
OMAiWVLQDCR.
OrthoDBiEOG7GXPCK.
PhylomeDBiD4A0Q3.

Enzyme and pathway databases

UniPathwayiUPA00989.

Miscellaneous databases

NextBioi740037.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03056. TRM82.
InterProiIPR028884. Trm82.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4A0Q3_RAT
AccessioniPrimary (citable) accession number: D4A0Q3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 27, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.