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Protein

Histone-lysine N-methyltransferase

Gene

Setdb1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

  • response to ethanol Source: RGD
  • response to vitamin Source: RGD

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-3214841 PKMTs methylate histone lysines

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Name:Setdb1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1308370 Setdb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiD4A081

PTM databases

iPTMnetiD4A081
PhosphoSitePlusiD4A081

Expressioni

Gene expression databases

BgeeiENSRNOG00000021143
ExpressionAtlasiD4A081 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini606 – 677MBDInterPro annotationAdd BLAST72
Domaini739 – 812Pre-SETInterPro annotationAdd BLAST74
Domaini815 – 1277SETInterPro annotationAdd BLAST463
Domaini1286 – 1302Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili37 – 64Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1141 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00780000121845
InParanoidiD4A081
KOiK11421
PhylomeDBiD4A081
TreeFamiTF106411

Family and domain databases

InterProiView protein in InterPro
IPR016177 DNA-bd_dom_sf
IPR025796 Hist-Lys_N-MeTrfase_SETDB1
IPR001739 Methyl_CpG_DNA-bd
IPR003616 Post-SET_dom
IPR007728 Pre-SET_dom
IPR001214 SET_dom
IPR002999 Tudor
PfamiView protein in Pfam
PF01429 MBD, 1 hit
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00391 MBD, 1 hit
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit
SM00333 TUDOR, 2 hits
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS50982 MBD, 1 hit
PS50868 POST_SET, 1 hit
PS50867 PRE_SET, 1 hit
PS51573 SAM_MT43_SUVAR39_1, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

D4A081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQFIDEELEK
60 70 80 90 100
MDCIQQRKKQ LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY
110 120 130 140 150
SKLGLQYHDS SSDDEASQPT EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL
160 170 180 190 200
REAMAALRKS AQDVQKFMDA VNKKSSSQDL HKGTLGQVSG ELSKDGDLIV
210 220 230 240 250
SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS LLSGNHIAYD
260 270 280 290 300
YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG
310 320 330 340 350
YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS
360 370 380 390 400
GQLIKTEWEG TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS
410 420 430 440 450
MKTSSASAME KKQGGQLRTR PNMGAVRSKG PVVQYTQDLT STGIQFKPME
460 470 480 490 500
PLQPIVPPAP LPMLPLSPQA GDSESLESQL AQSRKQVAKK STSFRPGSVS
510 520 530 540 550
SGHSSPTSPT LSENVPPGKI GMNQTYRSPS ASVTSTPAPA APSGPPAPPG
560 570 580 590 600
PLAPPGPPAP PAFHGMLERA PAEPSYRAPM EKLFYLPHVC SYTCLSRIRP
610 620 630 640 650
MRNEQYRGKN PLLVPLLYDF RRMTARRRVN RKMGFHVIYK TPCGLCLRTM
660 670 680 690 700
QEIERYLFET GCDFLYLEMF CLDPYVLVDR KFQPFKPFYY ILDITYGKED
710 720 730 740 750
VPLSCVNEID TTPPPQVAYS KERIPGKGVF INTGPEFLVG CDCKDGCRDK
760 770 780 790 800
SKCACHQLTV QATACTPGGQ INPSSGYQHK RLEECLPTGV YECNKRCKCD
810 820 830 840 850
PNMCTNRLVQ HGLQVRLQLF KTQNKGWGIR CLDDIAKGSF VCIYAGKILT
860 870 880 890 900
DDFADKEGLE MGDEYFANLD HIESVENFKE GYESDVPSSS DSSGVDMKDQ
910 920 930 940 950
EDGNSGSEDP EESNDDSSDD NFCKDEDFST SSVWRSYATR RQTRGQKESE
960 970 980 990 1000
LSEVTSKDSR APDRGPPHVP ITPSGSVGGC NPPSSEETPK NKVASWLSCN
1010 1020 1030 1040 1050
SVSEGGFADS DSRSSFKTSE GGDGRAGGGR GEAERASTSG LSFKDEGDSK
1060 1070 1080 1090 1100
QSKKEDPEDR NKMSVVTEGS QNHGHNPPMK SEGLRRPASK ISMLQSQRVV
1110 1120 1130 1140 1150
TSTQSNPDDI LTLSSSTESE GESGTSRKPT TGQTSATAVD SDDIQTISSG
1160 1170 1180 1190 1200
SDGDDFEDKK NLSGPTKRQV AVKSTRGFAL KSTHGIAIKS TNMASVDKGE
1210 1220 1230 1240 1250
SAPVRKNTRQ FYDGEESCYI IDAKLEGNLG RYLNHSCSPN LFVQNVFVDT
1260 1270 1280 1290 1300
HDLRFPWVAF FASKRIRAGT ELTWDYNYEV GSVEGKELLC CCGAIECRGR

LL
Length:1,302
Mass (Da):143,989
Last modified:April 20, 2010 - v1
Checksum:i27FDEE0A030ADEBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC094497 Genomic DNA No translation available.
RefSeqiNP_001258104.1, NM_001271175.1
XP_006232976.1, XM_006232914.2
UniGeneiRn.140824

Genome annotation databases

EnsembliENSRNOT00000028709; ENSRNOP00000028709; ENSRNOG00000021143
GeneIDi689883
KEGGirno:689883
UCSCiRGD:1308370 rat

Similar proteinsi

Entry informationi

Entry nameiD4A081_RAT
AccessioniPrimary (citable) accession number: D4A081
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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