Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Protein Setdb1

Gene

Setdb1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • response to ethanol Source: RGD
  • response to vitamin Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-3214841. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Setdb1Imported
Gene namesi
Name:Setdb1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1308370. Setdb1.

Subcellular locationi

  • Chromosome SAAS annotation
  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiD4A081.
PeptideAtlasiD4A081.

PTM databases

iPTMnetiD4A081.
PhosphoSiteiD4A081.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021143.
ExpressionAtlasiD4A081. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028709.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini606 – 67772MBD (methyl-CpG-binding)InterPro annotationAdd
BLAST
Domaini739 – 81274Pre-SETInterPro annotationAdd
BLAST
Domaini815 – 1277463SETInterPro annotationAdd
BLAST
Domaini1286 – 130217Post-SETInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili37 – 6428Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains 1 pre-SET domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1141. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
InParanoidiD4A081.
KOiK11421.
PhylomeDBiD4A081.
TreeFamiTF106411.

Family and domain databases

InterProiIPR016177. DNA-bd_dom.
IPR025796. Hist-Lys_N-MeTrfase_SETDB1.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00391. MBD. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00333. TUDOR. 2 hits.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51573. SAM_MT43_SUVAR39_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQFIDEELEK
60 70 80 90 100
MDCIQQRKKQ LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY
110 120 130 140 150
SKLGLQYHDS SSDDEASQPT EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL
160 170 180 190 200
REAMAALRKS AQDVQKFMDA VNKKSSSQDL HKGTLGQVSG ELSKDGDLIV
210 220 230 240 250
SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS LLSGNHIAYD
260 270 280 290 300
YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG
310 320 330 340 350
YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS
360 370 380 390 400
GQLIKTEWEG TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS
410 420 430 440 450
MKTSSASAME KKQGGQLRTR PNMGAVRSKG PVVQYTQDLT STGIQFKPME
460 470 480 490 500
PLQPIVPPAP LPMLPLSPQA GDSESLESQL AQSRKQVAKK STSFRPGSVS
510 520 530 540 550
SGHSSPTSPT LSENVPPGKI GMNQTYRSPS ASVTSTPAPA APSGPPAPPG
560 570 580 590 600
PLAPPGPPAP PAFHGMLERA PAEPSYRAPM EKLFYLPHVC SYTCLSRIRP
610 620 630 640 650
MRNEQYRGKN PLLVPLLYDF RRMTARRRVN RKMGFHVIYK TPCGLCLRTM
660 670 680 690 700
QEIERYLFET GCDFLYLEMF CLDPYVLVDR KFQPFKPFYY ILDITYGKED
710 720 730 740 750
VPLSCVNEID TTPPPQVAYS KERIPGKGVF INTGPEFLVG CDCKDGCRDK
760 770 780 790 800
SKCACHQLTV QATACTPGGQ INPSSGYQHK RLEECLPTGV YECNKRCKCD
810 820 830 840 850
PNMCTNRLVQ HGLQVRLQLF KTQNKGWGIR CLDDIAKGSF VCIYAGKILT
860 870 880 890 900
DDFADKEGLE MGDEYFANLD HIESVENFKE GYESDVPSSS DSSGVDMKDQ
910 920 930 940 950
EDGNSGSEDP EESNDDSSDD NFCKDEDFST SSVWRSYATR RQTRGQKESE
960 970 980 990 1000
LSEVTSKDSR APDRGPPHVP ITPSGSVGGC NPPSSEETPK NKVASWLSCN
1010 1020 1030 1040 1050
SVSEGGFADS DSRSSFKTSE GGDGRAGGGR GEAERASTSG LSFKDEGDSK
1060 1070 1080 1090 1100
QSKKEDPEDR NKMSVVTEGS QNHGHNPPMK SEGLRRPASK ISMLQSQRVV
1110 1120 1130 1140 1150
TSTQSNPDDI LTLSSSTESE GESGTSRKPT TGQTSATAVD SDDIQTISSG
1160 1170 1180 1190 1200
SDGDDFEDKK NLSGPTKRQV AVKSTRGFAL KSTHGIAIKS TNMASVDKGE
1210 1220 1230 1240 1250
SAPVRKNTRQ FYDGEESCYI IDAKLEGNLG RYLNHSCSPN LFVQNVFVDT
1260 1270 1280 1290 1300
HDLRFPWVAF FASKRIRAGT ELTWDYNYEV GSVEGKELLC CCGAIECRGR

LL
Length:1,302
Mass (Da):143,989
Last modified:April 20, 2010 - v1
Checksum:i27FDEE0A030ADEBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC094497 Genomic DNA. No translation available.
RefSeqiNP_001258104.1. NM_001271175.1.
XP_006232976.1. XM_006232914.2.
UniGeneiRn.140824.

Genome annotation databases

EnsembliENSRNOT00000028709; ENSRNOP00000028709; ENSRNOG00000021143.
GeneIDi689883.
KEGGirno:689883.
UCSCiRGD:1308370. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC094497 Genomic DNA. No translation available.
RefSeqiNP_001258104.1. NM_001271175.1.
XP_006232976.1. XM_006232914.2.
UniGeneiRn.140824.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028709.

PTM databases

iPTMnetiD4A081.
PhosphoSiteiD4A081.

Proteomic databases

PaxDbiD4A081.
PeptideAtlasiD4A081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028709; ENSRNOP00000028709; ENSRNOG00000021143.
GeneIDi689883.
KEGGirno:689883.
UCSCiRGD:1308370. rat.

Organism-specific databases

CTDi9869.
RGDi1308370. Setdb1.

Phylogenomic databases

eggNOGiKOG1141. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
InParanoidiD4A081.
KOiK11421.
PhylomeDBiD4A081.
TreeFamiTF106411.

Enzyme and pathway databases

ReactomeiR-RNO-3214841. PKMTs methylate histone lysines.

Gene expression databases

BgeeiENSRNOG00000021143.
ExpressionAtlasiD4A081. baseline and differential.

Family and domain databases

InterProiIPR016177. DNA-bd_dom.
IPR025796. Hist-Lys_N-MeTrfase_SETDB1.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00391. MBD. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00333. TUDOR. 2 hits.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51573. SAM_MT43_SUVAR39_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD4A081_RAT
AccessioniPrimary (citable) accession number: D4A081
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.