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Protein
Submitted name:

RAN-binding protein 2

Gene

Ranbp2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-RNO-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-RNO-191859 snRNP Assembly
R-RNO-2467813 Separation of Sister Chromatids
R-RNO-2500257 Resolution of Sister Chromatid Cohesion
R-RNO-3108214 SUMOylation of DNA damage response and repair proteins
R-RNO-3301854 Nuclear Pore Complex (NPC) Disassembly
R-RNO-3371453 Regulation of HSF1-mediated heat shock response
R-RNO-4551638 SUMOylation of chromatin organization proteins
R-RNO-4570464 SUMOylation of RNA binding proteins
R-RNO-4615885 SUMOylation of DNA replication proteins
R-RNO-5578749 Transcriptional regulation by small RNAs
R-RNO-5663220 RHO GTPases Activate Formins
R-RNO-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Submitted name:
RAN-binding protein 2Imported
Gene namesi
Name:Ranbp2Imported
Synonyms:LOC100911178Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1560047 Ranbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiD4A054
PRIDEiD4A054

Expressioni

Gene expression databases

BgeeiENSRNOG00000000796
ExpressionAtlasiD4A054 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PrknQ9JK662EBI-973937,EBI-973793

GO - Molecular functioni

Protein-protein interaction databases

IntActiD4A054 1 interactor.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 93TPR_REGIONInterPro annotationAdd BLAST68
Repeati26 – 59TPRPROSITE-ProRule annotationAdd BLAST34
Repeati60 – 93TPRPROSITE-ProRule annotationAdd BLAST34
Domaini1165 – 1301RanBD1InterPro annotationAdd BLAST137
Domaini1345 – 1375RanBP2-typeInterPro annotationAdd BLAST31
Domaini1410 – 1439RanBP2-typeInterPro annotationAdd BLAST30
Domaini1473 – 1502RanBP2-typeInterPro annotationAdd BLAST30
Domaini1504 – 1533RanBP2-typeInterPro annotationAdd BLAST30
Domaini1567 – 1596RanBP2-typeInterPro annotationAdd BLAST30
Domaini1626 – 1655RanBP2-typeInterPro annotationAdd BLAST30
Domaini1858 – 1994RanBD1InterPro annotationAdd BLAST137
Domaini2155 – 2291RanBD1InterPro annotationAdd BLAST137
Domaini2746 – 2881RanBD1InterPro annotationAdd BLAST136
Domaini2902 – 3058PPIase cyclophilin-typeInterPro annotationAdd BLAST157

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili739 – 759Sequence analysisAdd BLAST21
Coiled coili811 – 831Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, TPR repeatPROSITE-ProRule annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0864 Eukaryota
KOG0865 Eukaryota
COG0652 LUCA
COG5171 LUCA
GeneTreeiENSGT00760000119119
TreeFamiTF314797

Family and domain databases

Gene3Di1.25.40.101 hit
2.30.29.304 hits
2.40.100.101 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
IPR022011 IR1-M
IPR011993 PH-like_dom_sf
IPR000156 Ran_bind_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PfamiView protein in Pfam
PF12185 IR1-M, 2 hits
PF00160 Pro_isomerase, 1 hit
PF00638 Ran_BP1, 4 hits
PF00641 zf-RanBP, 6 hits
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00160 RanBD, 4 hits
SM00028 TPR, 1 hit
SM00547 ZnF_RBZ, 6 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF50891 SSF50891, 1 hit
SSF90209 SSF90209, 5 hits
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
PS50196 RANBD1, 4 hits
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit
PS01358 ZF_RANBP2_1, 6 hits
PS50199 ZF_RANBP2_2, 6 hits

Sequencei

Sequence statusi: Complete.

D4A054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSKAEVER YIASVQGSAP SPREKSMKGF YFAKLYYEAK EYDLAKKYIS
60 70 80 90 100
TYINVQERDP KAHRFLGLLY EIEENTDKAV ECYKRSVELN PTQKDLVLKI
110 120 130 140 150
AELLCKNDVT DGRAKYWVER AAKLFPGSPA IYKLKEQLLD CKGEDGWNKL
160 170 180 190 200
FDLIQSELYA RPDDVHVNIR LVELYRSNKR LKDAVAHCHE ADRNMALRSS
210 220 230 240 250
LEWNSCVVQT LKEYLESLQC LDSDKSTWRA TNKDLLLAYS NLMLLTLSTR
260 270 280 290 300
DVQESRELLE SFDSALQSVK SSVGGNDELS ATFLETKGHF YMHVGSLLLK
310 320 330 340 350
MGQQSDIQWR ALSELAALCY LIAFQVPRPK VKLIKGETGQ NLLEMMAHDR
360 370 380 390 400
LSQSGHMLLN LSRGKQDFLK EVVESFANKS GQSALCDALF SSQSSKDRSF
410 420 430 440 450
LGNDDIGNLD GQVPDLDDLA RYDTGAVRAH SGSLQHLTWL GLQWNSLPTL
460 470 480 490 500
PAIRKWLKQL FHHLPQETSR LETNAPESIC ILDLEVFLLG VIYTSHLQLR
510 520 530 540 550
EKSNSHHTSY QPLCLPLPVC RQLCTERQKS WWDAVCTLIH RKALPGTSAK
560 570 580 590 600
LRLLVQREIN SLRGQEKHGL QPALLVHWAQ SLQKTGSSLN SFYDQREYIG
610 620 630 640 650
RSVHYWRKVL PLLKMIRKKN SIPEPIDPLF KHFHSVDIQV SEIGEYEEDA
660 670 680 690 700
HITFAILDAV NGNIEDAMTA FESIKNVVSY WNLALIFHRK AEDIENDALS
710 720 730 740 750
PEEQEECKNY LRKTRDYLIK ILDDSDSNIS VVQKLPVPLE SVKEMLNSVM
760 770 780 790 800
QELEDYSEGG TLYKNGCFRS ADSELKHSTP SPTKYSLSPS KSYKYSPKTP
810 820 830 840 850
PRWAEDQNSL LKMICQQVEA IKKEMQELKL NSNNSASPHR WPAEHYRQDP
860 870 880 890 900
VPDGYQGSQT FHGAPLTVAT TGPSVYYSQS PAYNSQYLLR PAANVTPTKG
910 920 930 940 950
PVYGMNRLPP QQHIYAYSQQ MHTPPVQSSS SCMFSQEMYG PPLRFESPAT
960 970 980 990 1000
GILSPRGDDY FNYNVQQTST NPPLPEPGYF TKPPLVAHAS RSGESKVIEF
1010 1020 1030 1040 1050
GKSNFVQPMQ GEVIRPPLAT PAHTTQPTPF KFNSNFKSND GDFTFSSPQV
1060 1070 1080 1090 1100
VTQSPSTAYS NSESLLGLLT SDKPLQGDGY SGLKPISAQT GGSRNTFSFG
1110 1120 1130 1140 1150
SKSTLTENMG PNQQKNFGFR RSDDMFTFHG PGKSIFTTPT SELANKSHET
1160 1170 1180 1190 1200
DGGSAHGDEE DDGPHFEPVV PLPDKIEVKT GEEDEEEFFC NRAKLFRFDG
1210 1220 1230 1240 1250
ESKEWKERGI GNVKILRHKT SGKIRLLMRR EQVLKICANH YISPDMKLTP
1260 1270 1280 1290 1300
NAGSDRSFVW HALDYADELP KPEQLAIRFK TPEEAALFKC KFEEAQNILK
1310 1320 1330 1340 1350
ALGTNASTAA NHTLRIVKEP ATQDNKDICK SDGGNLNFEF QIVKKEGPFW
1360 1370 1380 1390 1400
NCNSCSFKNA ATATKCVSCQ NTKPTNGKEL LGSPLVENGF ASKTGPENVQ
1410 1420 1430 1440 1450
DRFALMTPNK EGHWDCSVCL VRNEPTVSRC IACQNTKSAN KNGSSFAQTS
1460 1470 1480 1490 1500
FKFGQGDLSK SADSDFRSVF SKKEGQWDCS ICLVRNEASS TKCVACQNPA
1510 1520 1530 1540 1550
KQAPEGQWDC SLCSVRNEAN AVKCVACQNP VKPSSSTTVT VLPSFKFGTS
1560 1570 1580 1590 1600
EMTKPPRSGF EGMFAKKEGQ WDCSLCFVRN EASASQCIAC QNPNKQNQPT
1610 1620 1630 1640 1650
SAVSAPASSE TSKSPKCGFE GLFTRKEGEW ECTVCSVQNE SSSLKCVSCD
1660 1670 1680 1690 1700
ASKPTHKPIA EAPSAFTVGS KSQLNESAGS QVGTEFKSNF PEKNFKVGIS
1710 1720 1730 1740 1750
EQKFKFGHVD QEKTPSFTFQ GSSNTEFKSI KDGFSFCIPV SADGFKFGIQ
1760 1770 1780 1790 1800
EKGNQEKKSE KHLENDPGFQ AHDTSGQKNG SGVVFGQTSS TFTFADLAKS
1810 1820 1830 1840 1850
TSREGFQFGK KDPNFKGFSG AGEKLFSSQS GKVAEKANTS DLEKDDDAYK
1860 1870 1880 1890 1900
TEDSDDIHFE PVVQMPEKVE LVTGEEDEKV LYSQRVKLFR FDAEISQWKE
1910 1920 1930 1940 1950
RGLGNLKILK NEVNGKLRML MRREQVLKVC ANHWITTTMN LKPLSGSDRA
1960 1970 1980 1990 2000
WMWLASDFSD GDAKLEQLAA KFKTPELAEE FKQKFEECQR LLLDIPLQTP
2010 2020 2030 2040 2050
HKLVDTGRAA KLIQRAEEMK SGLKDFKTFL TNDQAKVTEE ENTSSGADAS
2060 2070 2080 2090 2100
SASDTTVKQN PDNTGPALEW DNYDLREDAL DDSVSSSSVH ASPLASSPVR
2110 2120 2130 2140 2150
KNLFRFGEST TGFNFSFKSA LSPSKSPAKL NQSGTSVGTD EESDVTQEEE
2160 2170 2180 2190 2200
RDGQYFEPVV PLPDLIEVSS GEENEQVVFS HRAKLYRYDK DVGQWKERGI
2210 2220 2230 2240 2250
GDIKILQNYD NKQVRIVMRR DQVLKLCANH RITPDMTLQT MKGTERVWVW
2260 2270 2280 2290 2300
TACDFADGER KIEHLAVRFK LQDVADSFKK IFDEAKTAQE KDCLITPHVS
2310 2320 2330 2340 2350
HLSTPRESPC GKIAIAVLEE TTRERTDLTQ GDEVVDTTSE AGETSSTSET
2360 2370 2380 2390 2400
TPKAVVSPPK FVFGSESVKS IFSSEKSKPF AFGNSSATGS LFGFSFNAPL
2410 2420 2430 2440 2450
KNSNSEISSI VQSGSEGKVD PDKGELPPNS DIKQSSDGKV KNLIAFSKET
2460 2470 2480 2490 2500
SSTFKTPEKA REKNKPEDPP SDTDILIVYE LTPTPEQKAL AEKLLLPSTF
2510 2520 2530 2540 2550
FCYKNRPGYV SEEEEDDEDF EMAVKKLNGK LYVDDSEKPL EENLADNDKE
2560 2570 2580 2590 2600
CVIVWEKKPT VEERAKADTL KLPPTFFCGV CSDTDEDNGN GEDFQSELRK
2610 2620 2630 2640 2650
VQEAQKSQSE KVTNTVGIEQ TGETEATNPD GSKSEEPDSD TKHSSSSPVP
2660 2670 2680 2690 2700
GTMDKPVDLS TKKETDMEFP SQGESKTVLF GFGSGTGLSF ADLASSNSGD
2710 2720 2730 2740 2750
FAFGPKDKNF QWANTGAAVF GTQSTSKDGD DEDGSDEDVV HNEDIHFEPI
2760 2770 2780 2790 2800
VSLPEVEVKS GEEDEEVLFK ERAKLYRWDR DVSQWKERGI GDIKILWHSV
2810 2820 2830 2840 2850
KNYYRILMRR DQVFKVCANH VITKAMELKP LNFSNNALVW TASDYADGEA
2860 2870 2880 2890 2900
KIEQLAVRFK TKEITECFKK KIEECQQNIM KLQNGQVSLA AELSKETNPV
2910 2920 2930 2940 2950
VFFDVCVDGE PLGRIIMELF SNIVPQTAEN FRALCTGEKG FGFKNSIFHR
2960 2970 2980 2990 3000
VVPDFICQGG DITKYNGTGG QSIYGDKFDD ENFDLKHTGP GLLSMANCGQ
3010 3020 3030 3040 3050
NTNSSQFFIT LKKAEHLDFK HVVFGFVKDG MDTVRKIESF GSPKGSVSRR

ICITECGQL
Length:3,059
Mass (Da):341,402
Last modified:July 22, 2015 - v2
Checksum:i2360D82745A4825B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07044953 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000001044; ENSRNOP00000001044; ENSRNOG00000000796
UCSCiRGD:1560047 rat

Similar proteinsi

Entry informationi

Entry nameiD4A054_RAT
AccessioniPrimary (citable) accession number: D4A054
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: April 25, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported