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Protein
Submitted name:

Protein Ranbp2

Gene

Ranbp2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_294302. Nuclear Pore Complex (NPC) Disassembly.
REACT_297906. Separation of Sister Chromatids.
REACT_299983. Regulation of HSF1-mediated heat shock response.
REACT_311041. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_316496. Resolution of Sister Chromatid Cohesion.
REACT_338831. Mitotic Prometaphase.
REACT_341230. Transcriptional regulation by small RNAs.
REACT_360167. SUMOylation of DNA damage response and repair proteins.
REACT_362301. RHO GTPases Activate Formins.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Ranbp2Imported
Gene namesi
Name:Ranbp2Imported
Synonyms:LOC100911178Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1560047. Ranbp2.

PTM / Processingi

Proteomic databases

PRIDEiD4A054.

Expressioni

Gene expression databases

ExpressionAtlasiD4A054. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Park2Q9JK662EBI-973937,EBI-973793

Protein-protein interaction databases

IntActiD4A054. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliD4A054.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains PPIase cyclophilin-type domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119119.
PhylomeDBiD4A054.
TreeFamiTF314797.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
2.30.29.30. 4 hits.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR022011. IR1-M.
IPR011993. PH_like_dom.
IPR000156. Ran_bind_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF12185. IR1-M. 2 hits.
PF00160. Pro_isomerase. 1 hit.
PF00638. Ran_BP1. 4 hits.
PF00515. TPR_1. 1 hit.
PF00641. zf-RanBP. 6 hits.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00160. RanBD. 4 hits.
SM00547. ZnF_RBZ. 6 hits.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS50196. RANBD1. 4 hits.
PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
PS01358. ZF_RANBP2_1. 6 hits.
PS50199. ZF_RANBP2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSKAEVER YIASVQGSAP SPREKSMKGF YFAKLYYEAK EYDLAKKYIS
60 70 80 90 100
TYINVQERDP KAHRFLGLLY EIEENTDKAV ECYKRSVELN PTQKDLVLKI
110 120 130 140 150
AELLCKNDVT DGRAKYWVER AAKLFPGSPA IYKLKEQLLD CKGEDGWNKL
160 170 180 190 200
FDLIQSELYA RPDDVHVNIR LVELYRSNKR LKDAVAHCHE ADRNMALRSS
210 220 230 240 250
LEWNSCVVQT LKEYLESLQC LDSDKSTWRA TNKDLLLAYS NLMLLTLSTR
260 270 280 290 300
DVQESRELLE SFDSALQSVK SSVGGNDELS ATFLETKGHF YMHVGSLLLK
310 320 330 340 350
MGQQSDIQWR ALSELAALCY LIAFQVPRPK VKLIKGETGQ NLLEMMAHDR
360 370 380 390 400
LSQSGHMLLN LSRGKQDFLK EVVESFANKS GQSALCDALF SSQSSKDRSF
410 420 430 440 450
LGNDDIGNLD GQVPDLDDLA RYDTGAVRAH SGSLQHLTWL GLQWNSLPTL
460 470 480 490 500
PAIRKWLKQL FHHLPQETSR LETNAPESIC ILDLEVFLLG VIYTSHLQLR
510 520 530 540 550
EKSNSHHTSY QPLCLPLPVC RQLCTERQKS WWDAVCTLIH RKALPGTSAK
560 570 580 590 600
LRLLVQREIN SLRGQEKHGL QPALLVHWAQ SLQKTGSSLN SFYDQREYIG
610 620 630 640 650
RSVHYWRKVL PLLKMIRKKN SIPEPIDPLF KHFHSVDIQV SEIGEYEEDA
660 670 680 690 700
HITFAILDAV NGNIEDAMTA FESIKNVVSY WNLALIFHRK AEDIENDALS
710 720 730 740 750
PEEQEECKNY LRKTRDYLIK ILDDSDSNIS VVQKLPVPLE SVKEMLNSVM
760 770 780 790 800
QELEDYSEGG TLYKNGCFRS ADSELKHSTP SPTKYSLSPS KSYKYSPKTP
810 820 830 840 850
PRWAEDQNSL LKMICQQVEA IKKEMQELKL NSNNSASPHR WPAEHYRQDP
860 870 880 890 900
VPDGYQGSQT FHGAPLTVAT TGPSVYYSQS PAYNSQYLLR PAANVTPTKG
910 920 930 940 950
PVYGMNRLPP QQHIYAYSQQ MHTPPVQSSS SCMFSQEMYG PPLRFESPAT
960 970 980 990 1000
GILSPRGDDY FNYNVQQTST NPPLPEPGYF TKPPLVAHAS RSGESKVIEF
1010 1020 1030 1040 1050
GKSNFVQPMQ GEVIRPPLAT PAHTTQPTPF KFNSNFKSND GDFTFSSPQV
1060 1070 1080 1090 1100
VTQSPSTAYS NSESLLGLLT SDKPLQGDGY SGLKPISAQT GGSRNTFSFG
1110 1120 1130 1140 1150
SKSTLTENMG PNQQKNFGFR RSDDMFTFHG PGKSIFTTPT SELANKSHET
1160 1170 1180 1190 1200
DGGSAHGDEE DDGPHFEPVV PLPDKIEVKT GEEDEEEFFC NRAKLFRFDG
1210 1220 1230 1240 1250
ESKEWKERGI GNVKILRHKT SGKIRLLMRR EQVLKICANH YISPDMKLTP
1260 1270 1280 1290 1300
NAGSDRSFVW HALDYADELP KPEQLAIRFK TPEEAALFKC KFEEAQNILK
1310 1320 1330 1340 1350
ALGTNASTAA NHTLRIVKEP ATQDNKDICK SDGGNLNFEF QIVKKEGPFW
1360 1370 1380 1390 1400
NCNSCSFKNA ATATKCVSCQ NTKPTNGKEL LGSPLVENGF ASKTGPENVQ
1410 1420 1430 1440 1450
DRFALMTPNK EGHWDCSVCL VRNEPTVSRC IACQNTKNGS SFAQTSFKFG
1460 1470 1480 1490 1500
QGDLSKSADS DFRSVFSKKE GQWDCSICLV RNEASSTKCV ACQNPAKQAK
1510 1520 1530 1540 1550
EGQWDCSLCS VRNEANAVKC VACQNPVKPS SSTTVTVLPS FKFGTSEMTK
1560 1570 1580 1590 1600
PPRSGFEGMF AKKEGQWDCS LCFVRNEASA SQCIACQNPN KQNQPTSAVS
1610 1620 1630 1640 1650
APASSETSKS PKCGFEGLFT RKEGEWECTV CSVQNESSSL KCVSCDASKP
1660 1670 1680 1690 1700
THKPIAEAPS AFTVGSKSQL NESAGSQVGT EFKSNFPEKN FKVGISEQKF
1710 1720 1730 1740 1750
KFGHVDQEKT PSFTFQGSSN TEFKSIKDGF SFCIPVSADG FKFGIQEKGN
1760 1770 1780 1790 1800
QEKKSEKHLE NDPGFQAHDT SGQKNGSGVV FGQTSSTFTF ADLAKSTSRE
1810 1820 1830 1840 1850
GFQFGKKDPN FKGFSGAGEK LFSSQSGKVA EKANTSDLEK DDDAYKTEDS
1860 1870 1880 1890 1900
DDIHFEPVVQ MPEKVELVTG EEDEKVLYSQ RVKLFRFDAE ISQWKERGLG
1910 1920 1930 1940 1950
NLKILKNEVN GKLRMLMRRE QVLKVCANHW ITTTMNLKPL SGSDRAWMWL
1960 1970 1980 1990 2000
ASDFSDGDAK LEQLAAKFKT PELAEEFKQK FEECQRLLLD IPLQTPHKLV
2010 2020 2030 2040 2050
DTGRAAKLIQ RAEEMKSGLK DFKTFLTNDQ AKVTEEENTS SGADASSASD
2060 2070 2080 2090 2100
TTVKQNPDNT GPALEWDNYD LREDALDDSV SSSSVHASPL ASSPVRKNLF
2110 2120 2130 2140 2150
RFGESTTGFN FSFKSALSPS KSPAKLNQSG TSVGTDEESD VTQEEERDGQ
2160 2170 2180 2190 2200
YFEPVVPLPD LIEVSSGEEN EQVVFSHRAK LYRYDKDVGQ WKERGIGDIK
2210 2220 2230 2240 2250
ILQNYDNKQV RIVMRRDQVL KLCANHRITP DMTLQTMKGT ERVWVWTACD
2260 2270 2280 2290 2300
FADGERKIEH LAVRFKLQDV ADSFKKIFDE AKTAQEKDCL ITPHVSHLST
2310 2320 2330 2340 2350
PRESPCGKIA IAVLEETTRE RTDLTQGDEV VDTTSEAGET SSTSETTPKA
2360 2370 2380 2390 2400
VVSPPKFVFG SESVKSIFSS EKSKPFAFGN SSATGSLFGF SFNAPLKNSN
2410 2420 2430 2440 2450
SEISSIVQSG SEGKVDPDKG ELPPNSDIKQ SSDGKVKNLI AFSKETSSTF
2460 2470 2480 2490 2500
KTPEKAREKN KPEDPPSDTD ILIVYELTPT PEQKALAEKL LLPSTFFCYK
2510 2520 2530 2540 2550
NRPGYVSEEE EDDEDFEMAV KKLNGKLYVD DSEKPLEENL ADNDKECVIV
2560 2570 2580 2590 2600
WEKKPTVEER AKADTLKLPP TFFCGVCSDT DEDNGNGEDF QSELRKVQEA
2610 2620 2630 2640 2650
QKSQSEKVTN TVGIEQTGET EATNPDGSKS EEPDSDTKHS SSSPVPGTMD
2660 2670 2680 2690 2700
KPVDLSTKKE TDMEFPSQGE SKTVLFGFGS GTGLSFADLA SSNSGDFAFG
2710 2720 2730 2740 2750
PKDKNFQWAN TGAAVFGTQS TSKDGDDEDG SDEDVVHNED IHFEPIVSLP
2760 2770 2780 2790 2800
EVEVKSGEED EEVLFKERAK LYRWDRDVSQ WKERGIGDIK ILWHSVKNYY
2810 2820 2830 2840 2850
RILMRRDQVF KVCANHVITK AMELKPLNFS NNALVWTASD YADGEAKIEQ
2860 2870 2880 2890 2900
LAVRFKTKEI TECFKKKIEE CQQNIMKLQN GQVSLAAELS KETNPVVFFD
2910 2920 2930 2940 2950
VCVDGEPLGR IIMELFSNIV PQTAENFRAL CTGEKGFGFK NSIFHRVVPD
2960 2970 2980 2990 3000
FICQGGDITK YNGTGGQSIY GDKFDDENFD LKHTGPGLLS MANCGQNTNS
3010 3020 3030 3040 3050
SQFFITLKKA EHLDFKHVVF GFVKDGMDTV RKIESFGSPK GSVSRRICIT

ECGQL
Length:3,055
Mass (Da):341,033
Last modified:April 20, 2010 - v1
Checksum:iB7F065BEAC73C878
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06100914 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000001044; ENSRNOP00000001044; ENSRNOG00000000796.
UCSCiRGD:1560047. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06100914 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD4A054.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiD4A054. 1 interaction.

Proteomic databases

PRIDEiD4A054.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001044; ENSRNOP00000001044; ENSRNOG00000000796.
UCSCiRGD:1560047. rat.

Organism-specific databases

RGDi1560047. Ranbp2.

Phylogenomic databases

GeneTreeiENSGT00760000119119.
PhylomeDBiD4A054.
TreeFamiTF314797.

Enzyme and pathway databases

ReactomeiREACT_294302. Nuclear Pore Complex (NPC) Disassembly.
REACT_297906. Separation of Sister Chromatids.
REACT_299983. Regulation of HSF1-mediated heat shock response.
REACT_311041. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_316496. Resolution of Sister Chromatid Cohesion.
REACT_338831. Mitotic Prometaphase.
REACT_341230. Transcriptional regulation by small RNAs.
REACT_360167. SUMOylation of DNA damage response and repair proteins.
REACT_362301. RHO GTPases Activate Formins.

Miscellaneous databases

NextBioi35571486.

Gene expression databases

ExpressionAtlasiD4A054. baseline and differential.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
2.30.29.30. 4 hits.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR022011. IR1-M.
IPR011993. PH_like_dom.
IPR000156. Ran_bind_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF12185. IR1-M. 2 hits.
PF00160. Pro_isomerase. 1 hit.
PF00638. Ran_BP1. 4 hits.
PF00515. TPR_1. 1 hit.
PF00641. zf-RanBP. 6 hits.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00160. RanBD. 4 hits.
SM00547. ZnF_RBZ. 6 hits.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS50196. RANBD1. 4 hits.
PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
PS01358. ZF_RANBP2_1. 6 hits.
PS50199. ZF_RANBP2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiD4A054_RAT
AccessioniPrimary (citable) accession number: D4A054
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 27, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.