ID   D4A005_RAT              Unreviewed;      1285 AA.
AC   D4A005;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 4.
DT   27-MAR-2024, entry version 101.
DE   SubName: Full=Euchromatic histone lysine methyltransferase 1 {ECO:0000313|Ensembl:ENSRNOP00000063511.4};
GN   Name=Ehmt1 {ECO:0000313|Ensembl:ENSRNOP00000063511.4,
GN   ECO:0000313|RGD:1307588};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000063511.4, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000063511.4, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000063511.4,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000063511.4}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000063511.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; D4A005; -.
DR   PaxDb; 10116-ENSRNOP00000063511; -.
DR   PeptideAtlas; D4A005; -.
DR   Ensembl; ENSRNOT00000066777.4; ENSRNOP00000063511.4; ENSRNOG00000007242.8.
DR   AGR; RGD:1307588; -.
DR   RGD; 1307588; Ehmt1.
DR   VEuPathDB; HostDB:ENSRNOG00000007242; -.
DR   eggNOG; KOG1082; Eukaryota.
DR   GeneTree; ENSGT00940000156002; -.
DR   HOGENOM; CLU_005790_3_0_1; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000007242; Expressed in thymus and 19 other cell types or tissues.
DR   ExpressionAtlas; D4A005; baseline and differential.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0070742; F:C2H2 zinc finger domain binding; ISO:RGD.
DR   GO; GO:0046976; F:histone H3K27 methyltransferase activity; ISO:RGD.
DR   GO; GO:0046974; F:histone H3K9 methyltransferase activity; ISO:RGD.
DR   GO; GO:0008168; F:methyltransferase activity; ISO:RGD.
DR   GO; GO:0002039; F:p53 binding; ISO:RGD.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISO:RGD.
DR   GO; GO:0001222; F:transcription corepressor binding; ISO:RGD.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; ISO:RGD.
DR   GO; GO:0006306; P:DNA methylation; ISO:RGD.
DR   GO; GO:0140718; P:facultative heterochromatin formation; ISO:RGD.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR   GO; GO:0045995; P:regulation of embryonic development; ISO:RGD.
DR   GO; GO:0060992; P:response to fungicide; IEP:RGD.
DR   CDD; cd20905; EHMT_ZBD; 1.
DR   CDD; cd10535; SET_EHMT1; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR043550; EHMT1/EHMT2.
DR   InterPro; IPR047762; EHMT_CRR.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR038035; SET_EHMT1.
DR   PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR   PANTHER; PTHR46307:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT1; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF13637; Ank_4; 1.
DR   Pfam; PF21533; EHMT1-2_CRR; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 7.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 5.
DR   PROSITE; PS50088; ANK_REPEAT; 5.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   Genevisible; D4A005; RN.
PE   1: Evidence at protein level;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:D4A005};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   REPEAT          759..791
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          792..824
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          825..849
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          859..891
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          925..957
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          1047..1110
FT                   /note="Pre-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50867"
FT   DOMAIN          1113..1230
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          27..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          327..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          640..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1261..1285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..177
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..196
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        332..349
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..382
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..402
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1261..1276
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1285 AA;  141096 MW;  76D1183B91528BD5 CRC64;
     MSAQAVLAKQ ETKQDCCMKT ELLREDTLMA ADEGSTEKQA GETPMAADGE TNGSCEKSGD
     ISHPNAPKHT QENTRASPQE GTNRVSRVAE NGVSERDTEV GKQNHVTADD FMQTSVIGSN
     GYFLNKPALQ GQPLRTPNTL NSSLPGHAAK TLPGGASKCR TPSALPQTPT TAPTVPGEGS
     ADTEDRKPTA SGTDVRVHRA RKTMPKSILG LHAASKDHRE VQDHKEPKED INRNISECGR
     QQLLPTFPAL HQSLPQNQCY MATTKSQTAA AVSRKKKRRM GTYSLVPKKK TKVLKQRTVI
     EMFKSITHST VGAKGEKVLD DSALHVNGES LEMDSEEEDS EELEDEEDRG AEQAAAFPTE
     DSRTSKESMS ETDRAAKMDG DSEEEQESPD TGEDEDGGDE SDLSSESSIK KKFLKRRGKT
     DSPWIKPARK RRRRSRKKPS SMLGSEACKS SPGSMEQAAL GDSAGYMEVS LDSLDLRVRG
     ILSSQTENEG LANGPDVLET DGLHEVPLCS CRMETPKSRE ISTLANNQCM ATESVDHELG
     RCTNSVVKYE LMRPSNKAPL LVLCEDHRGR MVKHQCCPGC GYFCTAGNFM ECQPESSISH
     RFHKDCASRV NNASYCPHCG EETSKAKEVT IAKADTTSTV TLAPGQEKSL AAEGRADTTT
     GSIAGAPEDE KSQSTVTQAP ECFDPAGPAG FVRPTSGFSQ GPGKETLESA LIALDSEKPK
     KLRFHPKQLY FSARQGELQK VLLMLVDGID PNFKMEHQSK RSPLHAAAEA GHVDICHMLV
     QAGANIDTCS EDQRTPLMEA AENNHLDAVK YLIKAGAQVD PKDAEGSTCL HLAAKKGHYD
     VVQYLLSNGQ MDVNCQDDGG WTPMIWATEY KHVDLVKLLL SKGSDINIRD NEENICLHWA
     AFSGCVDIAE ILLAAKCDLH AVNIHGDSPL HIAARENRYD CVVLFLSRDS DVTLKNKEGE
     TPLQCASLNS QVWSALQMSK ALQDSAPDKP VAVEKTVSRD IARGYERIPI PCVNAVDSEL
     CPTNYKYVSQ NCVTSPMNID RNITHLQYCV CVDDCSSSTC MCGQLSMRCW YDKDGRLLPE
     FNMAEPPLIF ECNHACSCWR NCRNRVVQNG LRARLQLYRT QDMGWGVRSL QDIPLGTFVC
     EYVGELISDS EADVREEDSY LFDLDNKDGE VYCIDARFYG NVSRFINHHC EPNLVPVRVF
     MSHQDLRFPR IAFFSTRLIQ AGEQLGFDYG ERFWDVKGKL FSCRCGSPKC RHSSAALAQR
     QASAAQEAQE NGLPDTSSAA AADPL
//