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D4A005

- D4A005_RAT

UniProt

D4A005 - D4A005_RAT

Protein
Submitted name:

Protein Ehmt1

Gene

Ehmt1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 2 (03 Apr 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. histone methyltransferase activity (H3-K27 specific) Source: Ensembl
    2. histone methyltransferase activity (H3-K9 specific) Source: Ensembl
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA methylation Source: Ensembl
    2. embryo development Source: Ensembl
    3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. peptidyl-lysine dimethylation Source: Ensembl
    5. peptidyl-lysine monomethylation Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_194748. Senescence-Associated Secretory Phenotype (SASP).

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Ehmt1Imported
    Gene namesi
    Name:Ehmt1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi1307588. Ehmt1.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-KW
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    ChromosomeSAAS annotation, NucleusUniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains 1 pre-SET domain.UniRule annotation
    Contains 7 ANK repeats.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains pre-SET domain.SAAS annotation

    Keywords - Domaini

    ANK repeatUniRule annotation, RepeatUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117632.
    OMAiSCWRTCK.
    OrthoDBiEOG744T8D.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR007728. Pre-SET_dom.
    IPR003606. Pre-SET_Zn-bd_sub.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 7 hits.
    SM00468. PreSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS50867. PRE_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4A005-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSETDRAAKS SESSIKKKFL KRRGKTDSPW IKPARKRRRR SRKKPSSMLG    50
    SEACKSSPGS MEQAALGDSA GYMEVSLDSL DLRVRGILSS QTENEGLANG 100
    PDVLETDGLH EVPLCSCRME TPKSREISTL ANNQCMATES VDHELGRCTN 150
    SVVKYELMRP SNKAPLLVLC EDHRGRMVKH QCCPGCGYFC TAGNFMECQP 200
    ESSISHRFHK DCASRVNNAS YCPHCGEETS KAKEVTIAKA DTTSTVTLAP 250
    GQEKSLAAEG RADTTTGSIA GAPEDEKSQS TVTQAPECFD PAGPAGFVRP 300
    TSGFSQGPGK ETLESALIAL DSEKPKKLRF HPKQLYFSAR QGELQKVLLM 350
    LVDGIDPNFK MEHQSKRSPL HAAAEAGHVD ICHMLVQAGA NIDTCSEDQR 400
    TPLMEAAENN HLDAVKYLIK AGAQVDPKDA EGSTCLHLAA KKGHYDVVQY 450
    LLSNGQMDVN CQDDGGWTPM IWATEYKHVD LVKLLLSKGS DINIRDNEEN 500
    ICLHWAAFSG CVDIAEILLA AKCDLHAVNI HGDSPLHIAA RENRYDCVVL 550
    FLSRDSDVTL KNKEGETPLQ CASLNSQVWS ALQMSKALQD SAPDKPVAVE 600
    KTVSRDIARG YERIPIPCVN AVDSELCPTN YKYVSQNCVT SPMNIDRNIT 650
    HLQYCVCVDD CSSSTCMCGQ LSMRCWYDKD GRLLPEFNMA EPPLIFECNH 700
    ACSCWRNCRN RVVQNGLRAR LQLYRTQDMG WGVRSLQDIP LGTFVCEYVG 750
    ELISDSEADV REEDSYLFDL DNKDGEVYCI DARFYGNVSR FINHHCEPNL 800
    VPVRVFMSHQ DLRFPRIAFF STRLIQAGEQ LGFDYGERFW DVKGKLFSCR 850
    CGSPKCRHSS AALAQRQASA AQEAQENGLP DTSSAAAADP L 891
    Length:891
    Mass (Da):98,427
    Last modified:April 3, 2013 - v2
    Checksum:iCB9C0D1FBF9B8D55
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06021873 Genomic DNA. No translation available.
    AABR06021874 Genomic DNA. No translation available.
    AABR06021875 Genomic DNA. No translation available.
    AABR06021876 Genomic DNA. No translation available.
    AABR06021877 Genomic DNA. No translation available.
    AABR06021878 Genomic DNA. No translation available.
    AABR06021879 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000066777; ENSRNOP00000063511; ENSRNOG00000007242.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06021873 Genomic DNA. No translation available.
    AABR06021874 Genomic DNA. No translation available.
    AABR06021875 Genomic DNA. No translation available.
    AABR06021876 Genomic DNA. No translation available.
    AABR06021877 Genomic DNA. No translation available.
    AABR06021878 Genomic DNA. No translation available.
    AABR06021879 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000066777 ; ENSRNOP00000063511 ; ENSRNOG00000007242 .

    Organism-specific databases

    RGDi 1307588. Ehmt1.

    Phylogenomic databases

    GeneTreei ENSGT00750000117632.
    OMAi SCWRTCK.
    OrthoDBi EOG744T8D.

    Enzyme and pathway databases

    Reactomei REACT_194748. Senescence-Associated Secretory Phenotype (SASP).

    Miscellaneous databases

    NextBioi 678572.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR007728. Pre-SET_dom.
    IPR003606. Pre-SET_Zn-bd_sub.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 7 hits.
    SM00468. PreSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS50867. PRE_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD4A005_RAT
    AccessioniPrimary (citable) accession number: D4A005
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 3, 2013
    Last modified: October 1, 2014
    This is version 41 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3