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D4A005

- D4A005_RAT

UniProt

D4A005 - D4A005_RAT

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Protein
Submitted name:

Protein Ehmt1

Gene
Ehmt1
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K27 specific) Source: Ensembl
  2. histone methyltransferase activity (H3-K9 specific) Source: Ensembl
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA methylation Source: Ensembl
  2. embryo development Source: Ensembl
  3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. peptidyl-lysine dimethylation Source: Ensembl
  5. peptidyl-lysine monomethylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

ReactomeiREACT_194748. Senescence-Associated Secretory Phenotype (SASP).

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Ehmt1Imported
Gene namesi
Name:Ehmt1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1307588. Ehmt1.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeSAAS annotations, NucleusUniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 pre-SET domain.UniRule annotation
Contains 7 ANK repeats.UniRule annotation
Contains SET domain.SAAS annotations
Contains pre-SET domain.SAAS annotations

Keywords - Domaini

ANK repeatUniRule annotation, RepeatUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00750000117632.
OMAiSCWRTCK.
OrthoDBiEOG744T8D.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A005-1 [UniParc]FASTAAdd to Basket

« Hide

MSETDRAAKS SESSIKKKFL KRRGKTDSPW IKPARKRRRR SRKKPSSMLG    50
SEACKSSPGS MEQAALGDSA GYMEVSLDSL DLRVRGILSS QTENEGLANG 100
PDVLETDGLH EVPLCSCRME TPKSREISTL ANNQCMATES VDHELGRCTN 150
SVVKYELMRP SNKAPLLVLC EDHRGRMVKH QCCPGCGYFC TAGNFMECQP 200
ESSISHRFHK DCASRVNNAS YCPHCGEETS KAKEVTIAKA DTTSTVTLAP 250
GQEKSLAAEG RADTTTGSIA GAPEDEKSQS TVTQAPECFD PAGPAGFVRP 300
TSGFSQGPGK ETLESALIAL DSEKPKKLRF HPKQLYFSAR QGELQKVLLM 350
LVDGIDPNFK MEHQSKRSPL HAAAEAGHVD ICHMLVQAGA NIDTCSEDQR 400
TPLMEAAENN HLDAVKYLIK AGAQVDPKDA EGSTCLHLAA KKGHYDVVQY 450
LLSNGQMDVN CQDDGGWTPM IWATEYKHVD LVKLLLSKGS DINIRDNEEN 500
ICLHWAAFSG CVDIAEILLA AKCDLHAVNI HGDSPLHIAA RENRYDCVVL 550
FLSRDSDVTL KNKEGETPLQ CASLNSQVWS ALQMSKALQD SAPDKPVAVE 600
KTVSRDIARG YERIPIPCVN AVDSELCPTN YKYVSQNCVT SPMNIDRNIT 650
HLQYCVCVDD CSSSTCMCGQ LSMRCWYDKD GRLLPEFNMA EPPLIFECNH 700
ACSCWRNCRN RVVQNGLRAR LQLYRTQDMG WGVRSLQDIP LGTFVCEYVG 750
ELISDSEADV REEDSYLFDL DNKDGEVYCI DARFYGNVSR FINHHCEPNL 800
VPVRVFMSHQ DLRFPRIAFF STRLIQAGEQ LGFDYGERFW DVKGKLFSCR 850
CGSPKCRHSS AALAQRQASA AQEAQENGLP DTSSAAAADP L 891
Length:891
Mass (Da):98,427
Last modified:April 3, 2013 - v2
Checksum:iCB9C0D1FBF9B8D55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06021873 Genomic DNA. No translation available.
AABR06021874 Genomic DNA. No translation available.
AABR06021875 Genomic DNA. No translation available.
AABR06021876 Genomic DNA. No translation available.
AABR06021877 Genomic DNA. No translation available.
AABR06021878 Genomic DNA. No translation available.
AABR06021879 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000066777; ENSRNOP00000063511; ENSRNOG00000007242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06021873 Genomic DNA. No translation available.
AABR06021874 Genomic DNA. No translation available.
AABR06021875 Genomic DNA. No translation available.
AABR06021876 Genomic DNA. No translation available.
AABR06021877 Genomic DNA. No translation available.
AABR06021878 Genomic DNA. No translation available.
AABR06021879 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000066777 ; ENSRNOP00000063511 ; ENSRNOG00000007242 .

Organism-specific databases

RGDi 1307588. Ehmt1.

Phylogenomic databases

GeneTreei ENSGT00750000117632.
OMAi SCWRTCK.
OrthoDBi EOG744T8D.

Enzyme and pathway databases

Reactomei REACT_194748. Senescence-Associated Secretory Phenotype (SASP).

Miscellaneous databases

NextBioi 678572.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 7 hits.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4A005_RAT
AccessioniPrimary (citable) accession number: D4A005
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: September 3, 2014
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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