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Protein
Submitted name:

Protein Dock1

Gene

Dock1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-418885. DCC mediated attractive signaling.
R-RNO-4420097. VEGFA-VEGFR2 Pathway.
R-RNO-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
R-RNO-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Dock1Imported
Gene namesi
Name:Dock1Imported
Synonyms:LOC100909609Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1566072. Dock1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiD3ZZW1.
PeptideAtlasiD3ZZW1.

PTM databases

iPTMnetiD3ZZW1.
PhosphoSiteiD3ZZW1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018683.
GenevisibleiD3ZZW1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051781.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 7062SH3InterPro annotationAdd
BLAST
Domaini425 – 609185DHR-1InterPro annotationAdd
BLAST
Domaini1207 – 1617411DHR-2InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1998. Eukaryota.
ENOG410XQH7. LUCA.
GeneTreeiENSGT00610000085806.
InParanoidiD3ZZW1.
KOiK13708.
OMAiAEKPGVN.
OrthoDBiEOG091G007D.
PhylomeDBiD3ZZW1.
TreeFamiTF300423.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR030717. DOCK1.
IPR010703. DOCK_C.
IPR032376. DOCK_N.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PTHR23317:SF79. PTHR23317:SF79. 1 hit.
PfamiPF06920. DHR-2. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF16172. DOCK_N. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZZW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRWVPTKRE EKYGVAFYNY DARGADELSL QIGDTVHILE TYEGWYRGYT
60 70 80 90 100
LRKKSKKGIF PASYIHLKEA IVEGKGQHET VIPGDLPLIQ EVTTTLREWS
110 120 130 140 150
TIWRQLYVQD NREMFRSVRH MIYDLIEWRS QILSGTLPQD ELKELKKKVT
160 170 180 190 200
AKIDYGNRIL DLDLVVRDED GNILDPELTS TISLFRAHEV ASKQVEERLQ
210 220 230 240 250
EEKSQKQNMD INRQAKFAAT PSLALFVNLK NVVCKIGEDA EVLMSLYDPV
260 270 280 290 300
ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ
310 320 330 340 350
IVRVGRMELR DSNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP
360 370 380 390 400
FQPVAGENDF LQTVINKVIA AKEVNHKGQG LWVTLKLLPG DIHQIRKEFP
410 420 430 440 450
HLVDRTTAVA RKTGFPEIIM PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV
460 470 480 490 500
TVSVYDEDGK RLEHVIFPGA GDEAISEYKS VIYYQVKQPR WFETLKVAIP
510 520 530 540 550
IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA LAFVKLMRYD GTTLRDGEHD
560 570 580 590 600
LIVYKAEAKK LEDAATYLSL PSTKGELEEK GHSATGKGMQ SLGSCTISKD
610 620 630 640 650
SFQISTLVCS TKLTQNVDLL GLLKWRSNTN LLQQNLRQLM KVDGGEVVKF
660 670 680 690 700
LQDTLDALFN IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET
710 720 730 740 750
YIKKHFSATL AYTKLTKVLR TYVASAEKPG INEQLYKAIK ALEYIFKFIV
760 770 780 790 800
RSRVLFNQLY ENKGEADFVE SLLQLFRSIN DMMSSMSELT VRVKGAALKY
810 820 830 840 850
LPTIVNDVKL VFDPKELSKM FTEFILNVPV GLLTVQKLYC LIEIVHSDLF
860 870 880 890 900
TQHDCREILL PMMTDQLKYH LERQEDLEAC CQLLSNILEV LYRKDVGPTQ
910 920 930 940 950
RHVQIIMEEL LRTVNRTVIS MGRDSELIGN FVACMTAILR QMEDFHYAHL
960 970 980 990 1000
IKTFGKMRTD VVDFLMETFI MFKNLIGKNV YPFDWVIMNT MQNKVFLRAI
1010 1020 1030 1040 1050
NQYADMLNKK FLDQANFELQ LWNNYFHLAV AFLTQESLQL ENFSSAKRAK
1060 1070 1080 1090 1100
ILNKYGDMRR QIGFEIRDMW YNLGQHKIKF IPEMVGPILE MTLIPETELR
1110 1120 1130 1140 1150
KATLPIFFDM MQCEFHSTRS FQMFENEIIT KLDHEVEGGR GDEQYKVLFD
1160 1170 1180 1190 1200
KILLEHCRKH KYLAKTGETF VKLVVRLMER LLDYRTIMHD ENKDNRMSCT
1210 1220 1230 1240 1250
VNVLNFYKEI EREEMYIRYL YKLCDLHKEC DNYTEAAYTL LLHAKLLKWS
1260 1270 1280 1290 1300
EDACAAHLIQ RDGFQATTQG QLKEQLYQEI IHYFDKGKMW EEAIALGKEL
1310 1320 1330 1340 1350
AEQYETELFD YEQLSELLKK QAQFYENIVK VIRPKPDYFA VGYYGQGFPS
1360 1370 1380 1390 1400
FLRGKVFIYR GKEYERREDF EARLLTQFPN AEKMKTTSPP GDDIKTSPGQ
1410 1420 1430 1440 1450
YIQCFTVKPK LDLPPKFHRP VSEQIVSFYR VNEVQRFEYS RPIRKGEKNP
1460 1470 1480 1490 1500
DNEFANMWIE RTIYTTAYKL PGILRWFEVK SVFMVEISPL ENAIETMQLT
1510 1520 1530 1540 1550
NDKISSMIQQ HLDDPGLPIN PLSMLLNGIV DPAVMGGFAN YEKAFFTDRY
1560 1570 1580 1590 1600
LQEHPEAHGQ IEKLKDLIAW QIPFLAEGIR IHGDKVTEAL RPFHERMEAC
1610 1620 1630 1640 1650
FKQLKEKVEK QYGVRTMPSG LDDRRGSRPR SMVRSFTMPS SSRPLSVASV
1660 1670 1680 1690 1700
SSFSSDSTPS RPGSDGFALE PLLPKKMHSR SQDKLDKDDP DKEKKDKKKE
1710 1720 1730 1740 1750
KRNSKHQEIF DKEFKPADSS LQQSEAVILS ETISPLRPQR PKSQVINVIG
1760 1770 1780 1790 1800
SERRFSVSPA SPCSQPTPPP VTPRAKLSFS IQPNLELNGM MGMDVADVPP
1810 1820 1830 1840 1850
PLPLKGNMAD YGNLMENQDL MGSPTSPPPP PQRQQPPPLP SKTPPPPPPK
1860
TTRKQTSVDS GIVQ
Length:1,864
Mass (Da):214,965
Last modified:April 20, 2010 - v1
Checksum:i442265FABF56286C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07005930 Genomic DNA. No translation available.
AABR07005931 Genomic DNA. No translation available.
AABR07005932 Genomic DNA. No translation available.
AABR07005933 Genomic DNA. No translation available.
AABR07005934 Genomic DNA. No translation available.
AABR07005935 Genomic DNA. No translation available.
AABR07005936 Genomic DNA. No translation available.
AABR07005937 Genomic DNA. No translation available.
RefSeqiNP_001137330.1. NM_001143858.1.
UniGeneiRn.1482.

Genome annotation databases

EnsembliENSRNOT00000054897; ENSRNOP00000051781; ENSRNOG00000018683.
GeneIDi309081.
KEGGirno:309081.
UCSCiRGD:1566072. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07005930 Genomic DNA. No translation available.
AABR07005931 Genomic DNA. No translation available.
AABR07005932 Genomic DNA. No translation available.
AABR07005933 Genomic DNA. No translation available.
AABR07005934 Genomic DNA. No translation available.
AABR07005935 Genomic DNA. No translation available.
AABR07005936 Genomic DNA. No translation available.
AABR07005937 Genomic DNA. No translation available.
RefSeqiNP_001137330.1. NM_001143858.1.
UniGeneiRn.1482.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051781.

PTM databases

iPTMnetiD3ZZW1.
PhosphoSiteiD3ZZW1.

Proteomic databases

PaxDbiD3ZZW1.
PeptideAtlasiD3ZZW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054897; ENSRNOP00000051781; ENSRNOG00000018683.
GeneIDi309081.
KEGGirno:309081.
UCSCiRGD:1566072. rat.

Organism-specific databases

CTDi1793.
RGDi1566072. Dock1.

Phylogenomic databases

eggNOGiKOG1998. Eukaryota.
ENOG410XQH7. LUCA.
GeneTreeiENSGT00610000085806.
InParanoidiD3ZZW1.
KOiK13708.
OMAiAEKPGVN.
OrthoDBiEOG091G007D.
PhylomeDBiD3ZZW1.
TreeFamiTF300423.

Enzyme and pathway databases

ReactomeiR-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-418885. DCC mediated attractive signaling.
R-RNO-4420097. VEGFA-VEGFR2 Pathway.
R-RNO-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
R-RNO-983231. Factors involved in megakaryocyte development and platelet production.

Gene expression databases

BgeeiENSRNOG00000018683.
GenevisibleiD3ZZW1. RN.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR030717. DOCK1.
IPR010703. DOCK_C.
IPR032376. DOCK_N.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PTHR23317:SF79. PTHR23317:SF79. 1 hit.
PfamiPF06920. DHR-2. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF16172. DOCK_N. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZZW1_RAT
AccessioniPrimary (citable) accession number: D3ZZW1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.