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Protein

Acetyl-coenzyme A synthetase

Gene

Acss1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

GO - Molecular functioni

  • acetate-CoA ligase activity Source: RGD
  • AMP binding Source: InterPro
  • ATP binding Source: UniProtKB-UniRule

GO - Biological processi

  • acetate biosynthetic process Source: RGD
  • acetyl-CoA biosynthetic process from acetate Source: InterPro
  • propionate biosynthetic process Source: RGD

Keywordsi

Molecular functionLigaseUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Gene namesi
Name:Acss1Imported
ORF Names:rCG_37494Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1306246 Acss1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiD3ZZN3
PRIDEiD3ZZN3

Expressioni

Gene expression databases

BgeeiENSRNOG00000007102

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009627

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 107ACAS_NInterPro annotationAdd BLAST57
Domaini109 – 548AMP-bindingInterPro annotationAdd BLAST440
Domaini557 – 635AMP-binding_CInterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1175 Eukaryota
COG0365 LUCA
GeneTreeiENSGT00910000144266
KOiK01895
OMAiVNCLDQH
OrthoDBiEOG091G039C
TreeFamiTF354241

Family and domain databases

CDDicd05966 ACS, 1 hit
InterProiView protein in InterPro
IPR011904 Ac_CoA_lig
IPR032387 ACAS_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
TIGRFAMsiTIGR02188 Ac_CoA_lig_AcsA, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZZN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARSLGSGV GRLLRGLHGH SGQSGWLLSL SRWTTTRFLG SVPAAAQLGS
60 70 80 90 100
YPALSAQAAQ EPAAFWGPLA RDTLVWDTPY HTVWDCDFRT GKIGWFLGGQ
110 120 130 140 150
LNVSVNCLDQ HVQKSPDTIA LIWERDEPGT EVRITYRELL ETTCRLANTL
160 170 180 190 200
KRHGVHRGDR VAIYMPVSPL AVAAMLACAR IGAIHTVVFA GFSAESLAGR
210 220 230 240 250
INDAKCKVVI TFNQGLRGGR VVELKKIVDE AVKNCPTVQH VLVAHRTDTK
260 270 280 290 300
VPMGNLDIPL EQEMANEAPV CTPESMNSED MLFMLYTSGS TGTPKGLVHT
310 320 330 340 350
QAGYLLYAAM THKLVFDYHP GDVFGCVADI GWITGHSYVV YGPLCNGATT
360 370 380 390 400
VLFESTPVYP DAGRYWETVQ RLKINQFYGA PTAVRLLLKF GDAWVKKYDR
410 420 430 440 450
SSLRTLGSVG EPINHEAWEW LHKVVGDGRC TLVDTWWQTE TGGICIAPRP
460 470 480 490 500
SEDGAEILPG MAMRPFFGIV PALMDEKGNV VEGGDVSGAL CISQAWPGMA
510 520 530 540 550
RTIYGDHQRF VDAYFRTYPG YYFTGDGAHR TEGGYYQITG RMDDVINISG
560 570 580 590 600
HRLGTAEIED AMADHPAVPE TAVIGYPHDI KGEAAFAFIV LKDDVRDANV
610 620 630 640 650
VVNELKLAVA TKIAKYAVPD QILVVKRLPK TRSGKVMRRL LRKIITSRGQ
660 670 680
DLGDTTTLED PSVITEIMSA FREYEEQRAA TN
Length:682
Mass (Da):74,892
Last modified:April 20, 2010 - v1
Checksum:iA9816B496C346055
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054290 Genomic DNA No translation available.
CH474050 Genomic DNA Translation: EDL86149.1
RefSeqiNP_001099994.1, NM_001106524.1
UniGeneiRn.98236

Genome annotation databases

EnsembliENSRNOT00000009627; ENSRNOP00000009627; ENSRNOG00000007102
GeneIDi296259
KEGGirno:296259
UCSCiRGD:1306246 rat

Similar proteinsi

Entry informationi

Entry nameiD3ZZN3_RAT
AccessioniPrimary (citable) accession number: D3ZZN3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health