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D3ZZN2

- D3ZZN2_RAT

UniProt

D3ZZN2 - D3ZZN2_RAT

Protein
Submitted name:

Protein Rasgrp3

Gene

Rasgrp3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. Rap GTPase activator activity Source: Ensembl
    3. Ras guanyl-nucleotide exchange factor activity Source: Ensembl

    GO - Biological processi

    1. Ras protein signal transduction Source: Ensembl

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factorSAAS annotation

    Keywords - Ligandi

    Metal-bindingSAAS annotation, ZincSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_199246. Activation of RAS in B cells.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Rasgrp3Imported
    Submitted name:
    RAS, guanyl releasing protein 3 (Predicted), isoform CRA_aImported
    Gene namesi
    Name:Rasgrp3Imported
    Synonyms:Rasgrp3_predictedImported
    ORF Names:rCG_61642Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi1304612. Rasgrp3.

    Subcellular locationi

    GO - Cellular componenti

    1. guanyl-nucleotide exchange factor complex Source: Ensembl
    2. perinuclear region of cytoplasm Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Contains N-terminal Ras-GEF domain.SAAS annotation
    Contains Ras-GEF domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117506.
    KOiK12362.
    OMAiISFTDYQ.
    OrthoDBiEOG72G16V.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    InterProiIPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view]
    PfamiPF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 1 hit.
    PROSITEiPS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3ZZN2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSNGLGKAA TLDELLSTCI EMFDDNGELN DSYLPRIMLL MHRWYLSSTE    50
    LAGKLLCMYR NASGESCDEF RLKICYFMRY WITKFPAEFN LDLGLIRMTE 100
    EFREVASQLG YEKHSNLMDI SSIPSYDWMR RVTQRKKVSK RGKACLLFDH 150
    LEPIELAEHL TFLEHKSFRR ISFTDYQSYV IHGCLENNPT LERSIALFNG 200
    ISKWVQLMVL SKPSAQQRAE VITKFINVAQ KLLQLKNFNT LMAVVGGLSH 250
    SSISRLKDTH SHLSSEVTKN WNEMTELVSS NGNYCNYRKA FADCDGFKIP 300
    ILGVHLKDLI AVHVIFPDWM EENKVNVVKM HQLSVTLSEL VSLQNASHHL 350
    EPNMDLINLL TLSLDLYHTE DDIYKLSLVL EPRNSKSQPT SPTTPNKPVV 400
    PLEWASEVVP KPDPTIINKH IRKLVELWGI IKQGYKCKDC GANCHKQCKD 450
    LLVLACRRLA RAPSLSSNPE SLPGSPALPP VQDEVFEFPG VTARHRDLDS 500
    RDITLVTGSS RKISVRVQRA TTSQATQTEP VWSEAVWGDS GSHTFPKMKS 550
    KLHDKAAKDK GFAKWENEKP TLHAGVDVVD RGTAFEPDQD DEQDEAQQGV 600
    EDG 603
    Length:603
    Mass (Da):68,292
    Last modified:April 20, 2010 - v1
    Checksum:iFF9F5B61EF414D51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06042252 Genomic DNA. No translation available.
    AABR06042253 Genomic DNA. No translation available.
    CH473947 Genomic DNA. Translation: EDM02825.1.
    RefSeqiNP_001101479.1. NM_001108009.1.
    UniGeneiRn.1995.

    Genome annotation databases

    EnsembliENSRNOT00000051239; ENSRNOP00000051116; ENSRNOG00000032703.
    GeneIDi313874.
    KEGGirno:313874.
    UCSCiRGD:1304612. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06042252 Genomic DNA. No translation available.
    AABR06042253 Genomic DNA. No translation available.
    CH473947 Genomic DNA. Translation: EDM02825.1 .
    RefSeqi NP_001101479.1. NM_001108009.1.
    UniGenei Rn.1995.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000051239 ; ENSRNOP00000051116 ; ENSRNOG00000032703 .
    GeneIDi 313874.
    KEGGi rno:313874.
    UCSCi RGD:1304612. rat.

    Organism-specific databases

    CTDi 25780.
    RGDi 1304612. Rasgrp3.

    Phylogenomic databases

    GeneTreei ENSGT00750000117506.
    KOi K12362.
    OMAi ISFTDYQ.
    OrthoDBi EOG72G16V.

    Enzyme and pathway databases

    Reactomei REACT_199246. Activation of RAS in B cells.

    Miscellaneous databases

    NextBioi 666946.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    InterProi IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view ]
    Pfami PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 1 hit.
    PROSITEi PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD3ZZN2_RAT
    AccessioniPrimary (citable) accession number: D3ZZN2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3