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Protein
Submitted name:

RAS guanyl-releasing protein 3

Gene

Rasgrp3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation
LigandMetal-bindingSAAS annotation, ZincSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-1169092 Activation of RAS in B cells
R-RNO-5673001 RAF/MAP kinase cascade

Names & Taxonomyi

Protein namesi
Submitted name:
RAS guanyl-releasing protein 3Imported
Submitted name:
RAS, guanyl releasing protein 3 (Predicted), isoform CRA_aImported
Gene namesi
Name:Rasgrp3Imported
Synonyms:Rasgrp3_predictedImported
ORF Names:rCG_61642Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1304612 Rasgrp3

Subcellular locationi

PTM / Processingi

Proteomic databases

PeptideAtlasiD3ZZN2

Expressioni

Gene expression databases

BgeeiENSRNOG00000032703
ExpressionAtlasiD3ZZN2 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051116

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 125N-terminal Ras-GEFInterPro annotationAdd BLAST123
Domaini152 – 383Ras-GEFInterPro annotationAdd BLAST232
Domaini427 – 456Phorbol-ester/DAG-typeInterPro annotationAdd BLAST30

Phylogenomic databases

eggNOGiKOG3417 Eukaryota
ENOG410XTGZ LUCA
GeneTreeiENSGT00910000144037
KOiK12362

Family and domain databases

CDDicd00029 C1, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR002219 PE/DAG-bd
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029645 RASGRP1/RASGRP3
PANTHERiPTHR23113:SF178 PTHR23113:SF178, 1 hit
PfamiView protein in Pfam
PF00617 RasGEF, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZZN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNGLGKAA TLDELLSTCI EMFDDNGELN DSYLPRIMLL MHRWYLSSTE
60 70 80 90 100
LAGKLLCMYR NASGESCDEF RLKICYFMRY WITKFPAEFN LDLGLIRMTE
110 120 130 140 150
EFREVASQLG YEKHSNLMDI SSIPSYDWMR RVTQRKKVSK RGKACLLFDH
160 170 180 190 200
LEPIELAEHL TFLEHKSFRR ISFTDYQSYV IHGCLENNPT LERSIALFNG
210 220 230 240 250
ISKWVQLMVL SKPSAQQRAE VITKFINVAQ KLLQLKNFNT LMAVVGGLSH
260 270 280 290 300
SSISRLKDTH SHLSSEVTKN WNEMTELVSS NGNYCNYRKA FADCDGFKIP
310 320 330 340 350
ILGVHLKDLI AVHVIFPDWM EENKVNVVKM HQLSVTLSEL VSLQNASHHL
360 370 380 390 400
EPNMDLINLL TLSLDLYHTE DDIYKLSLVL EPRNSKSQPT SPTTPNKPVV
410 420 430 440 450
PLEWASEVVP KPDPTIINKH IRKLVELWGI IKQGYKCKDC GANCHKQCKD
460 470 480 490 500
LLVLACRRLA RAPSLSSNPE SLPGSPALPP VQDEVFEFPG VTARHRDLDS
510 520 530 540 550
RDITLVTGSS RKISVRVQRA TTSQATQTEP VWSEAVWGDS GSHTFPKMKS
560 570 580 590 600
KLHDKAAKDK GFAKWENEKP TLHAGVDVVD RGTAFEPDQD DEQDEAQQGV

EDG
Length:603
Mass (Da):68,292
Last modified:April 20, 2010 - v1
Checksum:iFF9F5B61EF414D51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07063185 Genomic DNA No translation available.
CH473947 Genomic DNA Translation: EDM02825.1
RefSeqiNP_001101479.1, NM_001108009.1
UniGeneiRn.1995

Genome annotation databases

EnsembliENSRNOT00000051239; ENSRNOP00000051116; ENSRNOG00000032703
GeneIDi313874
KEGGirno:313874
UCSCiRGD:1304612 rat

Similar proteinsi

Entry informationi

Entry nameiD3ZZN2_RAT
AccessioniPrimary (citable) accession number: D3ZZN2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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