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D3ZZN2

- D3ZZN2_RAT

UniProt

D3ZZN2 - D3ZZN2_RAT

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Protein
Submitted name:

Protein Rasgrp3

Gene
Rasgrp3, Rasgrp3_predicted, rCG_61642
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. Rap GTPase activator activity Source: Ensembl
  3. Ras guanyl-nucleotide exchange factor activity Source: Ensembl

GO - Biological processi

  1. Ras protein signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotations

Keywords - Ligandi

Metal-bindingSAAS annotations, ZincSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_199246. Activation of RAS in B cells.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Rasgrp3Imported
Submitted name:
RAS, guanyl releasing protein 3 (Predicted), isoform CRA_aImported
Gene namesi
Name:Rasgrp3Imported
Synonyms:Rasgrp3_predictedImported
ORF Names:rCG_61642Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi1304612. Rasgrp3.

Subcellular locationi

GO - Cellular componenti

  1. guanyl-nucleotide exchange factor complex Source: Ensembl
  2. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains N-terminal Ras-GEF domain.SAAS annotations
Contains Ras-GEF domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117506.
KOiK12362.
OMAiISFTDYQ.
OrthoDBiEOG72G16V.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZZN2-1 [UniParc]FASTAAdd to Basket

« Hide

MGSNGLGKAA TLDELLSTCI EMFDDNGELN DSYLPRIMLL MHRWYLSSTE    50
LAGKLLCMYR NASGESCDEF RLKICYFMRY WITKFPAEFN LDLGLIRMTE 100
EFREVASQLG YEKHSNLMDI SSIPSYDWMR RVTQRKKVSK RGKACLLFDH 150
LEPIELAEHL TFLEHKSFRR ISFTDYQSYV IHGCLENNPT LERSIALFNG 200
ISKWVQLMVL SKPSAQQRAE VITKFINVAQ KLLQLKNFNT LMAVVGGLSH 250
SSISRLKDTH SHLSSEVTKN WNEMTELVSS NGNYCNYRKA FADCDGFKIP 300
ILGVHLKDLI AVHVIFPDWM EENKVNVVKM HQLSVTLSEL VSLQNASHHL 350
EPNMDLINLL TLSLDLYHTE DDIYKLSLVL EPRNSKSQPT SPTTPNKPVV 400
PLEWASEVVP KPDPTIINKH IRKLVELWGI IKQGYKCKDC GANCHKQCKD 450
LLVLACRRLA RAPSLSSNPE SLPGSPALPP VQDEVFEFPG VTARHRDLDS 500
RDITLVTGSS RKISVRVQRA TTSQATQTEP VWSEAVWGDS GSHTFPKMKS 550
KLHDKAAKDK GFAKWENEKP TLHAGVDVVD RGTAFEPDQD DEQDEAQQGV 600
EDG 603
Length:603
Mass (Da):68,292
Last modified:April 20, 2010 - v1
Checksum:iFF9F5B61EF414D51
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06042252 Genomic DNA. No translation available.
AABR06042253 Genomic DNA. No translation available.
CH473947 Genomic DNA. Translation: EDM02825.1.
RefSeqiNP_001101479.1. NM_001108009.1.
UniGeneiRn.1995.

Genome annotation databases

EnsembliENSRNOT00000051239; ENSRNOP00000051116; ENSRNOG00000032703.
GeneIDi313874.
KEGGirno:313874.
UCSCiRGD:1304612. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06042252 Genomic DNA. No translation available.
AABR06042253 Genomic DNA. No translation available.
CH473947 Genomic DNA. Translation: EDM02825.1 .
RefSeqi NP_001101479.1. NM_001108009.1.
UniGenei Rn.1995.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000051239 ; ENSRNOP00000051116 ; ENSRNOG00000032703 .
GeneIDi 313874.
KEGGi rno:313874.
UCSCi RGD:1304612. rat.

Organism-specific databases

CTDi 25780.
RGDi 1304612. Rasgrp3.

Phylogenomic databases

GeneTreei ENSGT00750000117506.
KOi K12362.
OMAi ISFTDYQ.
OrthoDBi EOG72G16V.

Enzyme and pathway databases

Reactomei REACT_199246. Activation of RAS in B cells.

Miscellaneous databases

NextBioi 666946.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
InterProi IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view ]
Pfami PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
PROSITEi PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD3ZZN2_RAT
AccessioniPrimary (citable) accession number: D3ZZN2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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