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Protein

GRIP and coiled-coil domain-containing protein 2

Gene

Gcc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
GRIP and coiled-coil domain-containing protein 2
Alternative name(s):
185 kDa Golgi coiled-coil protein
Gene namesi
Name:Gcc2
Synonyms:Gcc185
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305732. Gcc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16791679GRIP and coiled-coil domain-containing protein 2PRO_0000401197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei1474 – 14741PhosphoserineBy similarity
Modified residuei1478 – 14781PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiD3ZZL9.
PeptideAtlasiD3ZZL9.
PRIDEiD3ZZL9.

PTM databases

iPTMnetiD3ZZL9.
PhosphoSiteiD3ZZL9.
SwissPalmiD3ZZL9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000823.
GenevisibleiD3ZZL9. RN.

Interactioni

Subunit structurei

Homodimer. Interacts (via GRIP domain) with RAB6A (preferentially in its GTP-bound form). May interact (RAB6A-dependent) with ARL1; might be involved in GCC2 Golgi localization. Interacts with CLASP1 and CLASP2; recruits both proteins to membranes of the TGN. Interacts with STX16 (By similarity). Interacts (probably via GRIP domain) with RAB9A (preferentially in its GTP-bound form).By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001092.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1604 – 165451GRIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1569 – 1679111Mediates interaction with RAB9ABy similarityAdd
BLAST
Regioni1569 – 160840Mediates interaction with RAB6ABy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili35 – 14691435Sequence analysisAdd
BLAST

Domaini

Extended rod-like protein with coiled-coil domains.

Sequence similaritiesi

Contains 1 GRIP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IUCE. Eukaryota.
ENOG410Y42S. LUCA.
InParanoidiD3ZZL9.
KOiK20282.
OrthoDBiEOG091G042V.
PhylomeDBiD3ZZL9.
TreeFamiTF332907.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR032023. GCC2_Rab_bind.
IPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
PF16704. Rab_bind. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZZL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSAQDAVT AAPSGTPKSK LETLPREDLI KFAKKQMMLL QKAKARCTEL
60 70 80 90 100
DKEVEELKSK PVDGGTDDMI KVLTERLDAL LLEKAETEQQ CLCLKKENIK
110 120 130 140 150
MKQEVEDSVT KLEETQKEFE QSHRNYVREM ESVKNELIAV HSEHSKEKAA
160 170 180 190 200
LQRDLEGAVH RQAELLEQLK SQSDSEDNVK KLQEEIQNIT AAFEEQTSCL
210 220 230 240 250
QKQLEATSDE KQQEIIHLQK VIEDNAQHYQ KDINTFQEEI VQLRATHKEE
260 270 280 290 300
VNELMSQMET LAKEHEAAVN KLKENRVTLC ETSETIPENY QCESESLNED
310 320 330 340 350
TSDASQENQK CSVALQEDPF AEHTVYDKVR QLEDSLKELE SQHSILKDEV
360 370 380 390 400
TYMNNLKLKL EMDAQHIKDE FFHEREDLEF KINELLLAKE EQSYVVEKLK
410 420 430 440 450
YEREDLNRQL CCTVEQHNKE IQRLQEHHQK EISELSETFM SGSEKEKLAL
460 470 480 490 500
MFEIQGLKEQ CENLQHEKQE VVLNYESLRE MMEILQTELG ESAGKISQEF
510 520 530 540 550
ETMKQQQASD VHELQQKLRT AFNEKDALLE TINRLQGENE KLLSQELVSE
560 570 580 590 600
LESTMKNLKA DNSMYLASLG QKDTLLQELE AKISSLAEEK DDFISKIKTS
610 620 630 640 650
REEIDDLHQK WEREQKLSVE LREAAEQAAQ HNSELRQRVS ELTGKLDEIL
660 670 680 690 700
REKSQNDQNI MVQMKTMTED QEALSSKIKS LYEENNRLHS EKVQLSRDLE
710 720 730 740 750
ALQSQQDFAY KEHVAEFEKK LQLMVEERDD LNKLLENEQL QKSFVKTQLY
760 770 780 790 800
EFLKQMRPSI LEDNEEEDVV TVLKAVGESL VTVKEEKHNL VFEYDARVLE
810 820 830 840 850
LERRIKCLQE ESVVQCEELR ALVRDSEQEK ILLRKELDEV TSTKEALQCD
860 870 880 890 900
ILEMKNTNEK TSLENQTLST RVEELSRSLH SKNEVHNEKD LVIEHENLRL
910 920 930 940 950
SLEQRESELQ DVRAELMLLK DSLEKSPSVK NDQLSLVKEL EEKIESLEKE
960 970 980 990 1000
SKDKDEKISK IKLVAVRAKK ELDSNRKEAQ TLRDELESVQ SEKDRLSASM
1010 1020 1030 1040 1050
KEFIQGAESY KNLLLEYDKQ SEQLDVEKER ANNFEHHIED LTKQLRDSTC
1060 1070 1080 1090 1100
QYEKLTSDNE DLLARIETLQ ANARLLEAQI LEVQRAKGVV EKELEAEKLQ
1110 1120 1130 1140 1150
KEQKIKEHVS TTNELEELQL QFQKEKKQLQ KTMQELELVK KDAQQTTLMN
1160 1170 1180 1190 1200
MEIADYERLM KELNQKLTNK NSKIEDLEQE MKIQKQKQET LQEEMTSLQS
1210 1220 1230 1240 1250
SVQHYEEKNA QIKQLLVKTK KELADAKQAE TDHLLLQASL KGELEASQQQ
1260 1270 1280 1290 1300
VEVYKIQLAE MTSEKHKIHE HLKTSAEQHQ RTLSAYQQRV VALQEESRTA
1310 1320 1330 1340 1350
KAEQAAVTSE FENYKVRVHN VLKQQKNKSV SQAETEGAKQ EREHLEMLID
1360 1370 1380 1390 1400
QLKIKLQDSQ NSLQISVSEF QTLQSEHDTL LERHNRMLQE TVTKEAELRE
1410 1420 1430 1440 1450
KLCSAQSENT MLKSEHAQTM CQLTSQNEAL RNSFRDQVRH LQDEHRKTVE
1460 1470 1480 1490 1500
TLQHQLSKVE TQLFQLKSEP PTKSPASSHQ PSKSLRERRT TDLPLLDMHT
1510 1520 1530 1540 1550
VTREEGEGME TTDSESVSSA GTHIQSLEQL LSSPDSKLER LTEASLWHTE
1560 1570 1580 1590 1600
FTKEELAEKL SSTTKSADHL NGLLRETEAT NAILMEQIKL LKSEIRRLER
1610 1620 1630 1640 1650
NQEREKSVAN LEYLKNVLLR FIFLKPGSER ERLLPVIDTM LQLSPEEKGK
1660 1670
LATVAQGEEE SASRSSGWAS YLHSWSGLR
Length:1,679
Mass (Da):195,083
Last modified:April 20, 2010 - v1
Checksum:iD208E89250B0CF22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114045 Genomic DNA. No translation available.
CH474016 Genomic DNA. Translation: EDL93092.1.
RefSeqiNP_001101103.1. NM_001107633.1.
UniGeneiRn.139579.

Genome annotation databases

GeneIDi309798.
KEGGirno:309798.
UCSCiRGD:1305732. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114045 Genomic DNA. No translation available.
CH474016 Genomic DNA. Translation: EDL93092.1.
RefSeqiNP_001101103.1. NM_001107633.1.
UniGeneiRn.139579.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001092.

PTM databases

iPTMnetiD3ZZL9.
PhosphoSiteiD3ZZL9.
SwissPalmiD3ZZL9.

Proteomic databases

PaxDbiD3ZZL9.
PeptideAtlasiD3ZZL9.
PRIDEiD3ZZL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi309798.
KEGGirno:309798.
UCSCiRGD:1305732. rat.

Organism-specific databases

CTDi9648.
RGDi1305732. Gcc2.

Phylogenomic databases

eggNOGiENOG410IUCE. Eukaryota.
ENOG410Y42S. LUCA.
InParanoidiD3ZZL9.
KOiK20282.
OrthoDBiEOG091G042V.
PhylomeDBiD3ZZL9.
TreeFamiTF332907.

Miscellaneous databases

PROiD3ZZL9.

Gene expression databases

BgeeiENSRNOG00000000823.
GenevisibleiD3ZZL9. RN.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR032023. GCC2_Rab_bind.
IPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
PF16704. Rab_bind. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCC2_RAT
AccessioniPrimary (citable) accession number: D3ZZL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.