ID   CAT7_RAT                Reviewed;         331 AA.
AC   D3ZZ07;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   RecName: Full=Cathepsin 7 {ECO:0000312|EMBL:EDL93846.1};
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=Cts7;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:EDL93846.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in trophoblast cell proliferation and
CC       differentiation probably by affecting mitotic cell cycle progression.
CC       Proteolytic activity and nuclear localization are essential for its
CC       role in cell cycle progression (By similarity).
CC       {ECO:0000250|UniProtKB:Q91ZF2}.
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:Q91ZF2}. Lysosome
CC       {ECO:0000250|UniProtKB:Q91ZF2}. Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q91ZF2}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q91ZF2}. Nucleus {ECO:0000250|UniProtKB:Q91ZF2}.
CC       Secreted, extracellular space {ECO:0000250|UniProtKB:Q91ZF2}.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089}.
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DR   EMBL; CH474032; EDL93846.1; -; Genomic_DNA.
DR   RefSeq; NP_001099569.1; NM_001106099.1.
DR   AlphaFoldDB; D3ZZ07; -.
DR   SMR; D3ZZ07; -.
DR   STRING; 10116.ENSRNOP00000051349; -.
DR   MEROPS; C01.016; -.
DR   GlyCosmos; D3ZZ07; 1 site, No reported glycans.
DR   GlyGen; D3ZZ07; 1 site.
DR   PaxDb; 10116-ENSRNOP00000051349; -.
DR   Ensembl; ENSRNOT00000043686.3; ENSRNOP00000051349.2; ENSRNOG00000033540.3.
DR   Ensembl; ENSRNOT00055040662; ENSRNOP00055033028; ENSRNOG00055023677.
DR   Ensembl; ENSRNOT00060029569; ENSRNOP00060023787; ENSRNOG00060017317.
DR   Ensembl; ENSRNOT00065038841; ENSRNOP00065031501; ENSRNOG00065022743.
DR   GeneID; 290970; -.
DR   KEGG; rno:290970; -.
DR   UCSC; RGD:1309226; rat.
DR   AGR; RGD:1309226; -.
DR   CTD; 56092; -.
DR   RGD; 1309226; Cts7.
DR   eggNOG; KOG1543; Eukaryota.
DR   GeneTree; ENSGT00940000153321; -.
DR   HOGENOM; CLU_012184_1_2_1; -.
DR   InParanoid; D3ZZ07; -.
DR   OMA; LTEWEIW; -.
DR   OrthoDB; 4749218at2759; -.
DR   PhylomeDB; D3ZZ07; -.
DR   TreeFam; TF313739; -.
DR   PRO; PR:D3ZZ07; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Proteomes; UP000234681; Chromosome 17.
DR   GO; GO:0005768; C:endosome; ISO:RGD.
DR   GO; GO:0005576; C:extracellular region; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR   GO; GO:0005764; C:lysosome; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IBA:GO_Central.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0000278; P:mitotic cell cycle; ISO:RGD.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; ISO:RGD.
DR   GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR   GO; GO:0060707; P:trophoblast giant cell differentiation; ISO:RGD.
DR   CDD; cd02248; Peptidase_C1A; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR039417; Peptidase_C1A_papain-like.
DR   InterPro; IPR013201; Prot_inhib_I29.
DR   PANTHER; PTHR12411:SF56; CATHEPSIN 7; 1.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   Pfam; PF08246; Inhibitor_I29; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00848; Inhibitor_I29; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Disulfide bond; Endosome;
KW   Glycoprotein; Golgi apparatus; Hydrolase; Lysosome; Mitosis; Nucleus;
KW   Protease; Reference proteome; Secreted; Signal; Thiol protease; Zymogen.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..111
FT                   /note="Activation peptide"
FT                   /evidence="ECO:0000250|UniProtKB:O60911"
FT                   /id="PRO_0000415397"
FT   CHAIN           112..331
FT                   /note="Cathepsin 7"
FT                   /evidence="ECO:0000250|UniProtKB:O60911"
FT                   /id="PRO_0000415398"
FT   MOTIF           33..50
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q91ZF2"
FT   ACT_SITE        136
FT                   /evidence="ECO:0000250|UniProtKB:O60911"
FT   ACT_SITE        274
FT                   /evidence="ECO:0000250|UniProtKB:O60911"
FT   ACT_SITE        298
FT                   /evidence="ECO:0000250|UniProtKB:O60911"
FT   CARBOHYD        72
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        133..176
FT                   /evidence="ECO:0000250|UniProtKB:O60911"
FT   DISULFID        167..209
FT                   /evidence="ECO:0000250|UniProtKB:O60911"
FT   DISULFID        267..320
FT                   /evidence="ECO:0000250|UniProtKB:O60911"
SQ   SEQUENCE   331 AA;  37868 MW;  280B8F8ADD27E26F CRC64;
     MTVAVFLAIL CLRAALAAPR PDYSLDAEWE EWKRNNAKTY SPEEEKQRRA VWEENVKMIK
     WHTMQNGLWM NNFTIEMNEF GDMTGEEMRM MTDSSALTLR NGKHIQKRNV KIPKTLDWRD
     TGCVAPVRSQ GGCGACWAFS VAASIESQLF KKTGKLIPLS VQNLIDCTVT YGNNDCSGGK
     PYTAFQYVKN NGGLEAEATY PYEAKLRHCR YRPERSVVKI ARFFVVPRNE EALMQALVTY
     GPIAVAIDGS HASFKRYRGG IYHEPKCRRD TLDHGLLLVG YGYEGHESEN RKYWLLKNSH
     GEQWGERGYM KLPRDQNNYC GIASYAMYPL L
//