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D3ZZ07 (CAT7_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cathepsin 7

EC=3.4.22.-
Gene names
Name:Cts7
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in trophoblast cell proliferation and differentiation probably by affecting mitotic cell cycle progression. Proteolytic activity and nuclear localization are essential for its role in cell cycle progression By similarity. UniProtKB Q91ZF2

Subcellular location

Endosome By similarity. Lysosome By similarity. Cytoplasmperinuclear region By similarity. Golgi apparatus By similarity. Nucleus By similarity. Secretedextracellular space By similarity UniProtKB Q91ZF2.

Sequence similarities

Belongs to the peptidase C1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 11194Activation peptide By similarity UniProtKB O60911
PRO_0000415397
Chain112 – 331220Cathepsin 7 UniProtKB O60911
PRO_0000415398

Regions

Motif33 – 5018Nuclear localization signal By similarity UniProtKB Q91ZF2

Sites

Active site1361 By similarity UniProtKB O60911
Active site2741 By similarity UniProtKB O60911
Active site2981 By similarity UniProtKB O60911

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Disulfide bond133 ↔ 176 By similarity UniProtKB O60911
Disulfide bond167 ↔ 209 By similarity UniProtKB O60911
Disulfide bond267 ↔ 320 By similarity UniProtKB O60911

Sequences

Sequence LengthMass (Da)Tools
D3ZZ07 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: 280B8F8ADD27E26F

FASTA33137,868
        10         20         30         40         50         60 
MTVAVFLAIL CLRAALAAPR PDYSLDAEWE EWKRNNAKTY SPEEEKQRRA VWEENVKMIK 

        70         80         90        100        110        120 
WHTMQNGLWM NNFTIEMNEF GDMTGEEMRM MTDSSALTLR NGKHIQKRNV KIPKTLDWRD 

       130        140        150        160        170        180 
TGCVAPVRSQ GGCGACWAFS VAASIESQLF KKTGKLIPLS VQNLIDCTVT YGNNDCSGGK 

       190        200        210        220        230        240 
PYTAFQYVKN NGGLEAEATY PYEAKLRHCR YRPERSVVKI ARFFVVPRNE EALMQALVTY 

       250        260        270        280        290        300 
GPIAVAIDGS HASFKRYRGG IYHEPKCRRD TLDHGLLLVG YGYEGHESEN RKYWLLKNSH 

       310        320        330 
GEQWGERGYM KLPRDQNNYC GIASYAMYPL L 

« Hide

References

[1]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH474032 Genomic DNA. Translation: EDL93846.1.
RefSeqNP_001099569.1. NM_001106099.1.
UniGeneRn.218615.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC01.016.

Proteomic databases

PRIDED3ZZ07.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000043686; ENSRNOP00000051349; ENSRNOG00000033540.
GeneID290970.
KEGGrno:290970.
UCSCRGD:1309226. rat.

Organism-specific databases

CTD56092.
RGD1309226. Cts7.

Phylogenomic databases

GeneTreeENSGT00740000115223.
OMAGHESENR.
OrthoDBEOG786H3P.
PhylomeDBD3ZZ07.
TreeFamTF313739.

Family and domain databases

InterProIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio631903.
PROD3ZZ07.

Entry information

Entry nameCAT7_RAT
AccessionPrimary (citable) accession number: D3ZZ07
Entry history
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: April 20, 2010
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries