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D3ZZ07

- CAT7_RAT

UniProt

D3ZZ07 - CAT7_RAT

Protein

Cathepsin 7

Gene

Cts7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Involved in trophoblast cell proliferation and differentiation probably by affecting mitotic cell cycle progression. Proteolytic activity and nuclear localization are essential for its role in cell cycle progression By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei136 – 1361By similarity
    Active sitei274 – 2741By similarity
    Active sitei298 – 2981By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. negative regulation of mitotic cell cycle Source: Ensembl
    3. trophoblast giant cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Protein family/group databases

    MEROPSiC01.016.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin 7Imported (EC:3.4.22.-)
    Gene namesi
    Name:Cts7Imported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi1309226. Cts7.

    Subcellular locationi

    Endosome By similarity. Lysosome By similarity. Cytoplasmperinuclear region By similarity. Golgi apparatus By similarity. Nucleus By similarity. Secretedextracellular space By similarity

    GO - Cellular componenti

    1. endosome Source: UniProtKB-SubCell
    2. extracellular space Source: UniProtKB-SubCell
    3. Golgi apparatus Source: UniProtKB-SubCell
    4. lysosome Source: UniProtKB-SubCell
    5. nucleus Source: UniProtKB-SubCell
    6. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endosome, Golgi apparatus, Lysosome, Nucleus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 11194Activation peptideBy similarityPRO_0000415397Add
    BLAST
    Chaini112 – 331220Cathepsin 7By similarityPRO_0000415398Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 176By similarity
    Disulfide bondi167 ↔ 209By similarity
    Disulfide bondi267 ↔ 320By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PRIDEiD3ZZ07.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi33 – 5018Nuclear localization signalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00740000115223.
    OMAiGHESENR.
    OrthoDBiEOG786H3P.
    PhylomeDBiD3ZZ07.
    TreeFamiTF313739.

    Family and domain databases

    InterProiIPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    D3ZZ07-1 [UniParc]FASTAAdd to Basket

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    MTVAVFLAIL CLRAALAAPR PDYSLDAEWE EWKRNNAKTY SPEEEKQRRA    50
    VWEENVKMIK WHTMQNGLWM NNFTIEMNEF GDMTGEEMRM MTDSSALTLR 100
    NGKHIQKRNV KIPKTLDWRD TGCVAPVRSQ GGCGACWAFS VAASIESQLF 150
    KKTGKLIPLS VQNLIDCTVT YGNNDCSGGK PYTAFQYVKN NGGLEAEATY 200
    PYEAKLRHCR YRPERSVVKI ARFFVVPRNE EALMQALVTY GPIAVAIDGS 250
    HASFKRYRGG IYHEPKCRRD TLDHGLLLVG YGYEGHESEN RKYWLLKNSH 300
    GEQWGERGYM KLPRDQNNYC GIASYAMYPL L 331
    Length:331
    Mass (Da):37,868
    Last modified:April 20, 2010 - v1
    Checksum:i280B8F8ADD27E26F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474032 Genomic DNA. Translation: EDL93846.1.
    RefSeqiNP_001099569.1. NM_001106099.1.
    UniGeneiRn.218615.

    Genome annotation databases

    EnsembliENSRNOT00000043686; ENSRNOP00000051349; ENSRNOG00000033540.
    GeneIDi290970.
    KEGGirno:290970.
    UCSCiRGD:1309226. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474032 Genomic DNA. Translation: EDL93846.1 .
    RefSeqi NP_001099569.1. NM_001106099.1.
    UniGenei Rn.218615.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C01.016.

    Proteomic databases

    PRIDEi D3ZZ07.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000043686 ; ENSRNOP00000051349 ; ENSRNOG00000033540 .
    GeneIDi 290970.
    KEGGi rno:290970.
    UCSCi RGD:1309226. rat.

    Organism-specific databases

    CTDi 56092.
    RGDi 1309226. Cts7.

    Phylogenomic databases

    GeneTreei ENSGT00740000115223.
    OMAi GHESENR.
    OrthoDBi EOG786H3P.
    PhylomeDBi D3ZZ07.
    TreeFami TF313739.

    Miscellaneous databases

    NextBioi 631903.
    PROi D3ZZ07.

    Family and domain databases

    InterProi IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCAT7_RAT
    AccessioniPrimary (citable) accession number: D3ZZ07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3