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Protein

Cathepsin 7

Gene

Cts7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in trophoblast cell proliferation and differentiation probably by affecting mitotic cell cycle progression. Proteolytic activity and nuclear localization are essential for its role in cell cycle progression (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei136 – 1361By similarity
Active sitei274 – 2741By similarity
Active sitei298 – 2981By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. mitotic nuclear division Source: UniProtKB-KW
  3. negative regulation of mitotic cell cycle Source: Ensembl
  4. trophoblast giant cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_198631. Trafficking and processing of endosomal TLR.
REACT_198830. MHC class II antigen presentation.
REACT_199129. Assembly of collagen fibrils and other multimeric structures.
REACT_199177. Collagen degradation.
REACT_199178. Degradation of the extracellular matrix.

Protein family/group databases

MEROPSiC01.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin 7Imported (EC:3.4.22.-)
Gene namesi
Name:Cts7Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi1309226. Cts7.

Subcellular locationi

Endosome By similarity. Lysosome By similarity. Cytoplasmperinuclear region By similarity. Golgi apparatus By similarity. Nucleus By similarity. Secretedextracellular space By similarity

GO - Cellular componenti

  1. endosome Source: UniProtKB-SubCell
  2. extracellular space Source: UniProtKB-SubCell
  3. Golgi apparatus Source: UniProtKB-SubCell
  4. lysosome Source: UniProtKB-SubCell
  5. nucleus Source: UniProtKB-SubCell
  6. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Lysosome, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 11194Activation peptideBy similarityPRO_0000415397Add
BLAST
Chaini112 – 331220Cathepsin 7By similarityPRO_0000415398Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi133 ↔ 176By similarity
Disulfide bondi167 ↔ 209By similarity
Disulfide bondi267 ↔ 320By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiD3ZZ07.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi33 – 5018Nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00760000118871.
InParanoidiD3ZZ07.
OMAiGHESENR.
OrthoDBiEOG786H3P.
PhylomeDBiD3ZZ07.
TreeFamiTF313739.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3ZZ07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVAVFLAIL CLRAALAAPR PDYSLDAEWE EWKRNNAKTY SPEEEKQRRA
60 70 80 90 100
VWEENVKMIK WHTMQNGLWM NNFTIEMNEF GDMTGEEMRM MTDSSALTLR
110 120 130 140 150
NGKHIQKRNV KIPKTLDWRD TGCVAPVRSQ GGCGACWAFS VAASIESQLF
160 170 180 190 200
KKTGKLIPLS VQNLIDCTVT YGNNDCSGGK PYTAFQYVKN NGGLEAEATY
210 220 230 240 250
PYEAKLRHCR YRPERSVVKI ARFFVVPRNE EALMQALVTY GPIAVAIDGS
260 270 280 290 300
HASFKRYRGG IYHEPKCRRD TLDHGLLLVG YGYEGHESEN RKYWLLKNSH
310 320 330
GEQWGERGYM KLPRDQNNYC GIASYAMYPL L
Length:331
Mass (Da):37,868
Last modified:April 20, 2010 - v1
Checksum:i280B8F8ADD27E26F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474032 Genomic DNA. Translation: EDL93846.1.
RefSeqiNP_001099569.1. NM_001106099.1.
UniGeneiRn.218615.

Genome annotation databases

EnsembliENSRNOT00000043686; ENSRNOP00000051349; ENSRNOG00000033540.
GeneIDi290970.
KEGGirno:290970.
UCSCiRGD:1309226. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474032 Genomic DNA. Translation: EDL93846.1.
RefSeqiNP_001099569.1. NM_001106099.1.
UniGeneiRn.218615.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC01.016.

Proteomic databases

PRIDEiD3ZZ07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000043686; ENSRNOP00000051349; ENSRNOG00000033540.
GeneIDi290970.
KEGGirno:290970.
UCSCiRGD:1309226. rat.

Organism-specific databases

CTDi56092.
RGDi1309226. Cts7.

Phylogenomic databases

GeneTreeiENSGT00760000118871.
InParanoidiD3ZZ07.
OMAiGHESENR.
OrthoDBiEOG786H3P.
PhylomeDBiD3ZZ07.
TreeFamiTF313739.

Enzyme and pathway databases

ReactomeiREACT_198631. Trafficking and processing of endosomal TLR.
REACT_198830. MHC class II antigen presentation.
REACT_199129. Assembly of collagen fibrils and other multimeric structures.
REACT_199177. Collagen degradation.
REACT_199178. Degradation of the extracellular matrix.

Miscellaneous databases

NextBioi631903.
PROiD3ZZ07.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCAT7_RAT
AccessioniPrimary (citable) accession number: D3ZZ07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.