ID D3ZXT3_RAT Unreviewed; 849 AA. AC D3ZXT3; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 27-MAR-2024, entry version 86. DE SubName: Full=Vomeronasal 2 receptor, 69 {ECO:0000313|Ensembl:ENSRNOP00000044230.3}; GN Name=Vom2r69 {ECO:0000313|Ensembl:ENSRNOP00000044230.3, GN ECO:0000313|RGD:1564750}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000044230.3, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000044230.3, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000044230.3, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000044230.3} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000044230.3}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001092938.1; NM_001099468.1. DR AlphaFoldDB; D3ZXT3; -. DR SMR; D3ZXT3; -. DR PaxDb; 10116-ENSRNOP00000044230; -. DR Ensembl; ENSRNOT00000039900.4; ENSRNOP00000044230.3; ENSRNOG00000040210.3. DR GeneID; 289433; -. DR KEGG; rno:289433; -. DR UCSC; RGD:1564750; rat. DR AGR; RGD:1564750; -. DR CTD; 289433; -. DR RGD; 1564750; Vom2r69. DR eggNOG; KOG1056; Eukaryota. DR GeneTree; ENSGT00950000183069; -. DR HOGENOM; CLU_005389_5_0_1; -. DR InParanoid; D3ZXT3; -. DR OMA; ATHQIAN; -. DR OrthoDB; 4188279at2759; -. DR PhylomeDB; D3ZXT3; -. DR TreeFam; TF340115; -. DR Proteomes; UP000002494; Chromosome 14. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central. DR CDD; cd15283; 7tmC_V2R_pheromone; 1. DR CDD; cd06365; PBP1_pheromone_receptor; 1. DR Gene3D; 3.40.50.2300; -; 2. DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1. DR InterPro; IPR001828; ANF_lig-bd_rcpt. DR InterPro; IPR000337; GPCR_3. DR InterPro; IPR011500; GPCR_3_9-Cys_dom. DR InterPro; IPR038550; GPCR_3_9-Cys_sf. DR InterPro; IPR017978; GPCR_3_C. DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel. DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2. DR InterPro; IPR028082; Peripla_BP_I. DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1. DR PANTHER; PTHR24061:SF411; VOMERONASAL 2, RECEPTOR 10-RELATED; 1. DR Pfam; PF00003; 7tm_3; 1. DR Pfam; PF01094; ANF_receptor; 1. DR Pfam; PF07562; NCD3G; 1. DR PRINTS; PR00248; GPCRMGR. DR PRINTS; PR01535; VOMERONASL2R. DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1. DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1. PE 4: Predicted; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|ARBA:ARBA00023170}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transducer {ECO:0000256|ARBA:ARBA00023224}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..21 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 22..849 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003053323" FT TRANSMEM 590..615 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 627..648 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 660..684 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 704..728 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 748..772 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 784..804 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 810..832 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 590..849 FT /note="G-protein coupled receptors family 3 profile" FT /evidence="ECO:0000259|PROSITE:PS50259" SQ SEQUENCE 849 AA; 96772 MW; F80DC28D39DB1EEC CRC64; MKKLCAFTVS FLFLKFSLIL CSFTELSCFW RMKNSEDSDG DLRSDCGFVL LTTKKNIEDF YNDINEVRIP ARRYEFFLVM FFATDEINNN PYLLPNISLI FSIIAGLCED TLGVLDEIYS QQNNSWNIVN YICEKGQRCD IELTGPSWKA SVKLSIHSMI PSVRMCDTGC VFFGPFNPNL SDHDQFPYMY QIATKDTCLS HGMVSLILHF RWNWLGLVIS DDDQGIQFLS DLREEMQSHG ICLAFVNMIP ETMQVYMIKA KIYDKQIMTS SAKVVIIYGE MNSTLEVSFR RWSYLGVQRI WITTSQWDVI TIKKDFNLDF FHGTLTFAHH KVEVAKFRNF MQTRNPAKYP VKFFESVLGW NYFNCSISKN SNLMDHFIFN NTLEWIALNK YDMVLSEEGY NLYNAVYAVA HTYHELILQQ TESQNIAEPN GVFIDCQQVA SLLKTRVFTN PVGELVNMKH REKQCVEYDI FITWNFPEGL GLKVKIGSYF PCFPQSQQLH ISEDLEWATG GTSVPSSMCS ATCTAGFRKI HQKQTADCCF DCVQCPENEV SNETADMEQC VRCPDDMYAN LEQTQCLQRT VSFLAYDDPL GIALGCMALS FSAITILVLV TFVKYKDTPI VKANNRILSY ILLISLVFCF LCSLLFIGHP NQATCILQQT TFGVFFTVAI STVLAKTITV VMAFKLTTPG RRLRGMMITW ASNFVIPFCT LIQLVLCGIW LVTSPPFIDR DIQSEHGKTI IICNKGSVIA FHVVLGYLGS LALGSFTIAF LARNLPDRFN EAKFLTFSML VFYSVWITFL PVYHSTRGKV MVVVEVFSIL ASSADLLGCI FVQKCYIILV SSNSNFLHK //