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Protein

Histone H2A

Gene

H2afx

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: GO_Central
  • cellular response to gamma radiation Source: RGD
  • cellular senescence Source: RGD
  • cerebral cortex development Source: RGD
  • chromatin silencing Source: GO_Central
  • DNA damage checkpoint Source: Ensembl
  • double-strand break repair via homologous recombination Source: Ensembl
  • spermatogenesis Source: RGD

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-201722 Formation of the beta-catenin:TCF transactivating complex
R-RNO-212300 PRC2 methylates histones and DNA
R-RNO-2299718 Condensation of Prophase Chromosomes
R-RNO-2559580 Oxidative Stress Induced Senescence
R-RNO-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-RNO-2559586 DNA Damage/Telomere Stress Induced Senescence
R-RNO-3214858 RMTs methylate histone arginines
R-RNO-427359 SIRT1 negatively regulates rRNA expression
R-RNO-427413 NoRC negatively regulates rRNA expression
R-RNO-5250924 B-WICH complex positively regulates rRNA expression
R-RNO-5578749 Transcriptional regulation by small RNAs
R-RNO-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-RNO-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-RNO-5693571 Nonhomologous End-Joining (NHEJ)
R-RNO-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-RNO-69473 G2/M DNA damage checkpoint
R-RNO-73728 RNA Polymerase I Promoter Opening
R-RNO-73777 RNA Polymerase I Chain Elongation
R-RNO-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-RNO-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2AUniRule annotation
Gene namesi
Name:H2afxImported
ORF Names:rCG_57928Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1566119 H2afx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiD3ZXP3
PRIDEiD3ZXP3

Expressioni

Gene expression databases

BgeeiENSRNOG00000010386

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056469

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 89HistoneInterPro annotationAdd BLAST85
Domaini92 – 123Histone_H2A_CInterPro annotationAdd BLAST32

Sequence similaritiesi

Belongs to the histone H2A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00910000143981
KOiK11251
OMAiVIVECAC
OrthoDBiEOG091G0XGD
TreeFamiTF300137

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZXP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKTGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGHY AERVGAGAPV
60 70 80 90 100
YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGG
110 120 130 140
VTIAQGGVLP NIQAVLLPKK TSATVGPKAP AGGKKASQAS QEY
Length:143
Mass (Da):15,115
Last modified:April 20, 2010 - v1
Checksum:iD4683775D43CC7B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105645 Genomic DNA No translation available.
CH473975 Genomic DNA Translation: EDL95294.1
RefSeqiNP_001102761.1, NM_001109291.1
UniGeneiRn.2850

Genome annotation databases

EnsembliENSRNOT00000059715; ENSRNOP00000056469; ENSRNOG00000010386
GeneIDi500987
KEGGirno:500987
UCSCiRGD:1566119 rat

Similar proteinsi

Entry informationi

Entry nameiD3ZXP3_RAT
AccessioniPrimary (citable) accession number: D3ZXP3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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