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Protein

Histone H2A

Gene

H2afx

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: RGD
  • cellular response to gamma radiation Source: RGD
  • cellular senescence Source: RGD
  • cerebral cortex development Source: RGD
  • chromatin silencing Source: GO_Central
  • DNA damage checkpoint Source: RGD
  • DNA repair Source: RGD
  • double-strand break repair via homologous recombination Source: RGD
  • spermatogenesis Source: RGD

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-RNO-5693571. Nonhomologous End-Joining (NHEJ).
R-RNO-69473. G2/M DNA damage checkpoint.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2AUniRule annotation
Gene namesi
Name:H2afxImported
ORF Names:rCG_57928Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1566119. H2afx.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000010386.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056469.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 89HistoneInterPro annotationAdd BLAST85
Domaini92 – 123Histone_H2A_CInterPro annotationAdd BLAST32

Sequence similaritiesi

Belongs to the histone H2A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00760000118934.
KOiK11251.
OMAiMPNIHQT.
OrthoDBiEOG091G0XGD.
TreeFamiTF300137.

Family and domain databases

CDDicd00074. H2A. 1 hit.
InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
PRINTSiPR00620. HISTONEH2A.
SMARTiView protein in SMART
SM00414. H2A. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00046. HISTONE_H2A. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZXP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKTGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGHY AERVGAGAPV
60 70 80 90 100
YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGG
110 120 130 140
VTIAQGGVLP NIQAVLLPKK TSATVGPKAP AGGKKASQAS QEY
Length:143
Mass (Da):15,115
Last modified:April 20, 2010 - v1
Checksum:iD4683775D43CC7B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105645 Genomic DNA. No translation available.
CH473975 Genomic DNA. Translation: EDL95294.1.
RefSeqiNP_001102761.1. NM_001109291.1.
UniGeneiRn.2850.

Genome annotation databases

EnsembliENSRNOT00000059715; ENSRNOP00000056469; ENSRNOG00000010386.
GeneIDi500987.
KEGGirno:500987.
UCSCiRGD:1566119. rat.

Similar proteinsi

Entry informationi

Entry nameiD3ZXP3_RAT
AccessioniPrimary (citable) accession number: D3ZXP3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 22, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported