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Protein

HORMA domain-containing protein 1

Gene

Hormad1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Meiosis, Oogenesis, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
HORMA domain-containing protein 1
Gene namesi
Name:Hormad1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1564960. Hormad1.

Subcellular locationi

  • Nucleus By similarity
  • Chromosome By similarity

  • Note: Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-375 is restricted to unsynapsed chromosomal regions (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392HORMA domain-containing protein 1PRO_0000410914Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei374 – 3741PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated at Ser-375 in a SPO11-dependent manner.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD3ZWE7.

PTM databases

iPTMnetiD3ZWE7.
PhosphoSiteiD3ZWE7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021160.

Interactioni

Subunit structurei

Interacts with HORMAD2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063863.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 227203HORMAPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi381 – 3844Nuclear localization signalBy similarity

Sequence similaritiesi

Contains 1 HORMA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4652. Eukaryota.
ENOG410XT4N. LUCA.
GeneTreeiENSGT00390000018130.
InParanoidiD3ZWE7.
OMAiCKEEEIM.
OrthoDBiEOG091G0F8O.
TreeFamiTF313989.

Family and domain databases

Gene3Di3.30.900.10. 1 hit.
InterProiIPR003511. HORMA_dom.
[Graphical view]
PfamiPF02301. HORMA. 1 hit.
[Graphical view]
SUPFAMiSSF56019. SSF56019. 1 hit.
PROSITEiPS50815. HORMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZWE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMQLRRTA SMSALVFPNK ISTEQQSLMF VKRLLAVSVS CITYLRGIFP
60 70 80 90 100
ERAYGTRYLD DLCVKILKED KNCPGSSQLV KWMLGCYDAL QKKYLRMIIL
110 120 130 140 150
AVYTNPEDPQ TISECYQFKF KYTKNGPIMD FISKNQNNKS STTSADTKKA
160 170 180 190 200
SILLIRKIYV LMQNLGPLPN DVCLTMKLFY YDEVTPPDYQ PPGFKDGDCE
210 220 230 240 250
GVIFDGDPTY LNVGEVPTPF HTFRLKVTTE KERMENIDSA ILTPKDSKIP
260 270 280 290 300
FQKILMDKDD VEDENHNNFD IKTKMNEQNE NSGTSEIKEP NLDCKEEEIM
310 320 330 340 350
QFKKNQSSSI SQCQVEQLIS KTSELDVSES KTRSGKIFQC KMVNGNQQGQ
360 370 380 390
ISKENRKRSL RQSGKTVLHI LESSSQESVL KRRRVSEPNE HT
Length:392
Mass (Da):44,885
Last modified:April 20, 2010 - v1
Checksum:i9988EC445088A9F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474015 Genomic DNA. Translation: EDL85702.1.
RefSeqiNP_001102419.1. NM_001108949.1.
XP_006233013.1. XM_006232951.2.
UniGeneiRn.218539.

Genome annotation databases

EnsembliENSRNOT00000066821; ENSRNOP00000063863; ENSRNOG00000021160.
GeneIDi365868.
KEGGirno:365868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474015 Genomic DNA. Translation: EDL85702.1.
RefSeqiNP_001102419.1. NM_001108949.1.
XP_006233013.1. XM_006232951.2.
UniGeneiRn.218539.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063863.

PTM databases

iPTMnetiD3ZWE7.
PhosphoSiteiD3ZWE7.

Proteomic databases

PaxDbiD3ZWE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000066821; ENSRNOP00000063863; ENSRNOG00000021160.
GeneIDi365868.
KEGGirno:365868.

Organism-specific databases

CTDi84072.
RGDi1564960. Hormad1.

Phylogenomic databases

eggNOGiKOG4652. Eukaryota.
ENOG410XT4N. LUCA.
GeneTreeiENSGT00390000018130.
InParanoidiD3ZWE7.
OMAiCKEEEIM.
OrthoDBiEOG091G0F8O.
TreeFamiTF313989.

Miscellaneous databases

PROiD3ZWE7.

Gene expression databases

BgeeiENSRNOG00000021160.

Family and domain databases

Gene3Di3.30.900.10. 1 hit.
InterProiIPR003511. HORMA_dom.
[Graphical view]
PfamiPF02301. HORMA. 1 hit.
[Graphical view]
SUPFAMiSSF56019. SSF56019. 1 hit.
PROSITEiPS50815. HORMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHORM1_RAT
AccessioniPrimary (citable) accession number: D3ZWE7
Secondary accession number(s): D3ZZR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.