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Protein
Submitted name:

Protein Neu4

Gene

Neu4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: Ensembl

GO - Biological processi

  1. ganglioside catabolic process Source: Ensembl
  2. glycoprotein catabolic process Source: Ensembl
  3. oligosaccharide catabolic process Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_283933. Sialic acid metabolism.
REACT_330669. Glycosphingolipid metabolism.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Neu4Imported
Submitted name:
Sialidase 4 (Predicted)Imported
Gene namesi
Name:Neu4Imported
Synonyms:Neu4_predictedImported
ORF Names:rCG_55641Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1308624. Neu4.

Subcellular locationi

GO - Cellular componenti

  1. lysosome Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. organelle inner membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000011171.
InParanoidiD3ZWB7.
KOiK12357.
OMAiHIDCKEC.
OrthoDBiEOG7MSMNP.
PhylomeDBiD3ZWB7.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
InterProiIPR026946. Sialidase-4.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF8. PTHR10628:SF8. 1 hit.
SUPFAMiSSF50939. SSF50939. 2 hits.

Sequencei

Sequence statusi: Complete.

D3ZWB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPAHVPKRT VLFQRERTGL TYRVPALLCV PPRPTLLAFA EQRLSPDDSH
60 70 80 90 100
AHRLVLRRGT LTRGSVRWGV LSVLETAVLE EHRSMNPCPV LDEHSGTIFL
110 120 130 140 150
FFIAVRGHTP EAVQIATGKN AARLCCVTSC DAGLTWGSVR DLTEEAIGAA
160 170 180 190 200
LQDWATFAVG PGHGVQLRSG RLLVPAYTYH VDRRECFGRI CWTSPHSLAF
210 220 230 240 250
YSDDHGISWH CGGLVPNLRS GECQLAAVDG DFLYCNARSP LGNRVQALSA
260 270 280 290 300
DEGTSFLPGE LVPTLAETAR GCQGSIVGFP APPSIGPQDD RWLASPGNTP
310 320 330 340 350
HSPCFDLRVR ESLAEGARGF VEGWASRLLL CYPQSRGPEN HGLEPGPDGE
360 370 380 390 400
KTSWSPELPM SSASVRQSST WLLYSHPAGR RARLHMGIYL SRSPLDPHSW
410 420 430 440 450
TEPWIIYEGP SGYSDLAFLG PVPGASLAFA CLFESGTRAS YEDISFCLFS
460 470
LADVLENVPT GLEISSLRNK PQGHCWPS
Length:478
Mass (Da):52,045
Last modified:April 19, 2010 - v1
Checksum:iE59549DCEDE1C69B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06061641 Genomic DNA. No translation available.
CH473997 Genomic DNA. Translation: EDL91894.1.
RefSeqiNP_001101704.1. NM_001108234.1.
XP_008765616.1. XM_008767394.1.
UniGeneiRn.198849.

Genome annotation databases

EnsembliENSRNOT00000065533; ENSRNOP00000063883; ENSRNOG00000019031.
GeneIDi103690047.
316642.
KEGGirno:103690047.
rno:316642.
UCSCiRGD:1308624. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06061641 Genomic DNA. No translation available.
CH473997 Genomic DNA. Translation: EDL91894.1.
RefSeqiNP_001101704.1. NM_001108234.1.
XP_008765616.1. XM_008767394.1.
UniGeneiRn.198849.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000065533; ENSRNOP00000063883; ENSRNOG00000019031.
GeneIDi103690047.
316642.
KEGGirno:103690047.
rno:316642.
UCSCiRGD:1308624. rat.

Organism-specific databases

CTDi129807.
RGDi1308624. Neu4.

Phylogenomic databases

GeneTreeiENSGT00390000011171.
InParanoidiD3ZWB7.
KOiK12357.
OMAiHIDCKEC.
OrthoDBiEOG7MSMNP.
PhylomeDBiD3ZWB7.

Enzyme and pathway databases

ReactomeiREACT_283933. Sialic acid metabolism.
REACT_330669. Glycosphingolipid metabolism.

Miscellaneous databases

NextBioi671126.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
InterProiIPR026946. Sialidase-4.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF8. PTHR10628:SF8. 1 hit.
SUPFAMiSSF50939. SSF50939. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD3ZWB7_RAT
AccessioniPrimary (citable) accession number: D3ZWB7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 19, 2010
Last sequence update: April 19, 2010
Last modified: March 31, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.