Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Protein Appl1

Gene

Appl1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. regulation of establishment of protein localization to plasma membrane Source: Ensembl
  3. regulation of glucose import Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_234945. Role of DCC in regulating apoptosis.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Appl1Imported
Gene namesi
Name:Appl1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi1309388. Appl1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. endosome membrane Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. NuRD complex Source: Ensembl
  5. vesicle membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD3ZWA8.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00710000106752.
InParanoidiD3ZWA8.
OMAiSDVETMQ.
OrthoDBiEOG79PJPK.
TreeFamiTF328669.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR027267. AH/BAR-dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS01179. PID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D3ZWA8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
QTRSLLGVFE EDATAISNYM NQLYQAMHRI YDAQNELSAA THLTSKLLKE
60 70 80 90 100
YEKQRFPLGG DDEVMSSTLQ QFSKVIDELS SCHAVLSTQL ADAMMFPISQ
110 120 130 140 150
FKERDLKEIL TLKEVFQIAS NDHDAAINRY SRLSKKREND KVKYEVTEDV
160 170 180 190 200
YTSRKKQHQT MMHYFCALNT LQYKKKIALL EPLLGYMQAQ ISFFKMGSEN
210 220 230 240 250
LNGQLEEFLA NIGTSVQNVR REMDGDVETM QQTIEDLEVA SDPLYLPDPD
260 270 280 290 300
PTKFPVNRNL TRKAGYLNAR NKTGLVSSTW DRQFYFTQGG NLMSQARGDV
310 320 330 340 350
AGGLAMDIDN CSVMAVDCED RRYCFQITSF DGKKSSILQA ESKKDHEEWI
360 370 380 390 400
CTINNISKQI YLSENPEETA ARVNQSALEA VTPSPSFQQR HESLRPGGQS
410 420 430 440 450
RPPTARTSSS GSLGSESTNL AALSLDSLVA PDTPIQFDII SPVCEDQPGQ
460 470 480 490 500
AKAFGQGGRR TNPFGESGGS TKSETEDSIL HQLFIVRFLG SMEVKSDDHP
510 520 530 540 550
DVVYETMRQI LAARAIHNIF RMTESHLLVT CDCLKLIDPQ TQVTRLTFPL
560 570 580 590 600
PYVVLYATHQ ENKRLFGFVL RTSGGRSESN LSSVCYIFES NNEGEKICDS
610 620 630 640 650
VGLAKQIALH AELDRRASEK QKEIERVKEK QQKELSKQKE IEKDLEEQSR
660 670 680 690
LIAASSRPSQ SGSEGQLVLS SSQSEESDLG EEGKKRESEA
Length:690
Mass (Da):77,498
Last modified:April 3, 2013 - v2
Checksum:i7DDC1A474B099BE6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06086214 Genomic DNA. No translation available.
AABR06086215 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000018413; ENSRNOP00000018413; ENSRNOG00000013574.
UCSCiRGD:1309388. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06086214 Genomic DNA. No translation available.
AABR06086215 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiD3ZWA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018413; ENSRNOP00000018413; ENSRNOG00000013574.
UCSCiRGD:1309388. rat.

Organism-specific databases

RGDi1309388. Appl1.

Phylogenomic databases

GeneTreeiENSGT00710000106752.
InParanoidiD3ZWA8.
OMAiSDVETMQ.
OrthoDBiEOG79PJPK.
TreeFamiTF328669.

Enzyme and pathway databases

ReactomeiREACT_234945. Role of DCC in regulating apoptosis.

Miscellaneous databases

NextBioi34025762.
PROiD3ZWA8.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR027267. AH/BAR-dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS01179. PID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD3ZWA8_RAT
AccessioniPrimary (citable) accession number: D3ZWA8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: January 7, 2015
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.