Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Adaptor protein, phosphotyrosine-interacting with PH domain and leucine zipper 1

Gene

Appl1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-418889 Ligand-independent caspase activation via DCC

Names & Taxonomyi

Protein namesi
Submitted name:
Adaptor protein, phosphotyrosine-interacting with PH domain and leucine zipper 1Imported
Gene namesi
Name:Appl1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1309388 Appl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiD3ZWA8
PeptideAtlasiD3ZWA8
PRIDEiD3ZWA8

Expressioni

Gene expression databases

BgeeiENSRNOG00000013574
GenevisibleiD3ZWA8 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018413

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 339PHInterPro annotationAdd BLAST99
Domaini465 – 601PIDInterPro annotationAdd BLAST137

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili201 – 221Sequence analysisAdd BLAST21
Coiled coili591 – 629Sequence analysisAdd BLAST39

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0521 Eukaryota
KOG3536 Eukaryota
ENOG410ZISK LUCA
GeneTreeiENSGT00710000106752
InParanoidiD3ZWA8
OMAiSDVETMQ
OrthoDBiEOG091G08AV
TreeFamiTF328669

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR006020 PTB/PI_dom
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00462 PTB, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS01179 PID, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZWA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQLYQAMHR IYDAQNELSA ATHLTSKLLK EYEKQRFPLG GDDEVMSSTL
60 70 80 90 100
QQFSKVIDEL SSCHAVLSTQ LADAMMFPIS QFKERDLKEI LTLKEVFQIA
110 120 130 140 150
SNDHDAAINR YSRLSKKREN DKVKYEVTED VYTSRKKQHQ TMMHYFCALN
160 170 180 190 200
TLQYKKKIAL LEPLLGYMQA QISFFKMGSE NLNGQLEEFL ANIGTSVQNV
210 220 230 240 250
RREMDGDVET MQQTIEDLEV ASDPLYLPDP DPTKFPVNRN LTRKAGYLNA
260 270 280 290 300
RNKTGLVSST WDRQFYFTQG GNLMSQARGD VAGGLAMDID NCSVMAVDCE
310 320 330 340 350
DRRYCFQITS FDGKKSSILQ AESKKDHEEW ICTINNISKQ IYLSENPEET
360 370 380 390 400
AARVNQSALE AVTPSPSFQQ RHESLRPGGQ SRPPTARTSS SGSLGSESTN
410 420 430 440 450
LAALSLDSLV APDTPIQFDI ISPVCEDQPG QAKAFGQGGR RTNPFGESGG
460 470 480 490 500
STKSETEDSI LHQLFIVRFL GSMEVKSDDH PDVVYETMRQ ILAARAIHNI
510 520 530 540 550
FRMTESHLLV TCDCLKLIDP QTQVTRLTFP LPYVVLYATH QENKRLFGFV
560 570 580 590 600
LRTSGGRSES NLSSVCYIFE SNNEGEKICD SVGLAKQIAL HAELDRRASE
610 620 630 640 650
KQKEIERVKE KQQKELSKQK EIEKDLEEQS RLIAASSRPS QSGSEGQLVL
660 670
SSSQSEESDL GEEGKKRESE A
Length:671
Mass (Da):75,402
Last modified:July 22, 2015 - v3
Checksum:iE4FBA5B5DE096FF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07024511 Genomic DNA No translation available.
AABR07024512 Genomic DNA No translation available.
AABR07024513 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000018413; ENSRNOP00000018413; ENSRNOG00000013574
UCSCiRGD:1309388 rat

Similar proteinsi

Entry informationi

Entry nameiD3ZWA8_RAT
AccessioniPrimary (citable) accession number: D3ZWA8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: March 28, 2018
This is version 69 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health