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Protein

Inosine triphosphate pyrophosphatase

Gene

Itpa

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Magnesium or manganeseUniRule annotation1
Binding sitei56SubstrateUniRule annotation1
Metal bindingi72Magnesium or manganeseUniRule annotation1
Binding sitei172SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-15869. Metabolism of nucleotides.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine triphosphate pyrophosphataseUniRule annotation (EC:3.6.1.9UniRule annotation)
Short name:
ITPaseUniRule annotation
Short name:
Inosine triphosphataseUniRule annotation
Alternative name(s):
Non-canonical purine NTP pyrophosphataseUniRule annotation
Non-standard purine NTP pyrophosphataseUniRule annotation
Nucleoside-triphosphate diphosphataseUniRule annotation
Nucleoside-triphosphate pyrophosphataseUniRule annotation
Short name:
NTPaseUniRule annotation
Gene namesi
Name:Itpa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1589751. Itpa.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00004131012 – 198Inosine triphosphate pyrophosphataseAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineUniRule annotationBy similarity1
Modified residuei146PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiD3ZW55.
PeptideAtlasiD3ZW55.
PRIDEiD3ZW55.

PTM databases

SwissPalmiD3ZW55.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021233.
GenevisibleiD3ZW55. RN.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028838.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 19Substrate bindingUniRule annotation6
Regioni72 – 73Substrate bindingUniRule annotation2
Regioni149 – 152Substrate bindingUniRule annotation4
Regioni177 – 178Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the HAM1 NTPase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3222. Eukaryota.
COG0127. LUCA.
GeneTreeiENSGT00390000015399.
InParanoidiD3ZW55.
KOiK01519.
OMAiMKIYFAT.
OrthoDBiEOG091G0MUD.
PhylomeDBiD3ZW55.
TreeFamiTF105614.

Family and domain databases

CDDicd00515. HAM1. 1 hit.
Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_03148. HAM1_NTPase. 1 hit.
InterProiIPR002637. Ham1p-like.
IPR027502. ITPase.
IPR029001. ITPase-like_fam.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3ZW55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASLVGKKI VFVTGNAKKL EEVIQILGDK FPCTLVAQKI DLPEYQGEPD
60 70 80 90 100
EISIQKCQEA ARQVQGPVLV EDTCLCFNAL GGLPGPYIKW FLQKLKPEGL
110 120 130 140 150
YQLLAGFEDK SAYALCTFAL STGDPSQPVL LFRGKTPGQI VMPRGSRDFG
160 170 180 190
WDPCFQPDGY EQTYAEMPKA EKNTISHRFR ALFKLQEYFG VTDGAGDH
Length:198
Mass (Da):21,927
Last modified:April 20, 2010 - v1
Checksum:iB63D329C4984FFF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473949 Genomic DNA. Translation: EDL80207.1.
RefSeqiNP_001101244.1. NM_001107774.1.
UniGeneiRn.203856.

Genome annotation databases

EnsembliENSRNOT00000028838; ENSRNOP00000028838; ENSRNOG00000021233.
GeneIDi311422.
KEGGirno:311422.
UCSCiRGD:1589751. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473949 Genomic DNA. Translation: EDL80207.1.
RefSeqiNP_001101244.1. NM_001107774.1.
UniGeneiRn.203856.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028838.

PTM databases

SwissPalmiD3ZW55.

Proteomic databases

PaxDbiD3ZW55.
PeptideAtlasiD3ZW55.
PRIDEiD3ZW55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028838; ENSRNOP00000028838; ENSRNOG00000021233.
GeneIDi311422.
KEGGirno:311422.
UCSCiRGD:1589751. rat.

Organism-specific databases

CTDi3704.
RGDi1589751. Itpa.

Phylogenomic databases

eggNOGiKOG3222. Eukaryota.
COG0127. LUCA.
GeneTreeiENSGT00390000015399.
InParanoidiD3ZW55.
KOiK01519.
OMAiMKIYFAT.
OrthoDBiEOG091G0MUD.
PhylomeDBiD3ZW55.
TreeFamiTF105614.

Enzyme and pathway databases

ReactomeiR-RNO-15869. Metabolism of nucleotides.

Miscellaneous databases

PROiD3ZW55.

Gene expression databases

BgeeiENSRNOG00000021233.
GenevisibleiD3ZW55. RN.

Family and domain databases

CDDicd00515. HAM1. 1 hit.
Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_03148. HAM1_NTPase. 1 hit.
InterProiIPR002637. Ham1p-like.
IPR027502. ITPase.
IPR029001. ITPase-like_fam.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiITPA_RAT
AccessioniPrimary (citable) accession number: D3ZW55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.