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Protein
Submitted name:

Sortilin-related VPS10 domain-containing receptor 2

Gene

Sorcs2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Names & Taxonomyi

Protein namesi
Submitted name:
Sortilin-related VPS10 domain-containing receptor 2Imported
Gene namesi
Name:Sorcs2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1310621. Sorcs2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1078 – 1099HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 50Sequence analysisAdd BLAST50
ChainiPRO_500305303251 – 1158Sequence analysisAdd BLAST1108

Proteomic databases

PaxDbiD3ZW09.
PeptideAtlasiD3ZW09.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007033.
ExpressionAtlasiD3ZW09. baseline and differential.
GenevisibleiD3ZW09. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009960.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini815 – 875PKDInterPro annotationAdd BLAST61

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3511. Eukaryota.
ENOG410Y3W5. LUCA.
GeneTreeiENSGT00510000046443.
InParanoidiD3ZW09.
OMAiNVRSTKQ.
OrthoDBiEOG091G00JR.
TreeFamiTF324918.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR013783. Ig-like_fold.
IPR000601. PKD_dom.
IPR035986. PKD_dom_sf.
IPR031777. Sortilin_C.
IPR031778. Sortilin_N.
IPR006581. VPS10.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
PfamiView protein in Pfam
PF00801. PKD. 1 hit.
PF15902. Sortilin-Vps10. 1 hit.
PF15901. Sortilin_C. 1 hit.
SMARTiView protein in SMART
SM00602. VPS10. 1 hit.
SUPFAMiSSF49299. SSF49299. 1 hit.
PROSITEiView protein in PROSITE
PS50093. PKD. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZW09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHRGTPSAP KRPGLTAPDR SSQVLLPPCW PRSPLLLLLL VLVAACGAMG
60 70 80 90 100
RSPQPGRWGP SVQVTRLLPA GRTESSNRQD PQTRESEPGV PGLRPGSASG
110 120 130 140 150
PSTDGAPALG KGRRVRAAPV AGAASASRAQ VSLISTSFVL KGDATHNQAM
160 170 180 190 200
VHWTGENSSV ILILTKYYHA DMGKVLESSL WRSSDFGTTY TKLTLQPGVT
210 220 230 240 250
TVIDNFYICP ANKRKIILVS SSLGDREQSL FLSTDEGTTF QKYPVPFLVE
260 270 280 290 300
TLLFHPKEED KVLAYTKDSK LYVSSDLGKK WTLLQEQVTK DHVFWAVSGV
310 320 330 340 350
DDDPNLVHME ARDLSGGYRY YTCLIHNCSA QPHTAPFPGP TDRGSLTVQD
360 370 380 390 400
EYIFLKATST NRTKYYVSYR RSDFVLMKLP KYALPKDLQI ISTDEQQVFV
410 420 430 440 450
AVQEWNQVDT YNLYQSDLRG VRYSLVLENV RSSRQAEENV VIDILEVRGV
460 470 480 490 500
KGVFLANQKV DGKVTTVITY NKGRDWDYLR PPSTDMNGKP TNCQPPDCHL
510 520 530 540 550
HLHLRWADNP YVSGTVHTKD TAPGLIMGAG NLGSQLVEYK EEMYITSDCG
560 570 580 590 600
HTWRQVFEEE HHVLYLDHGG VIAAIKDTSI PLKTLKFSVD EGHTWSTHNF
610 620 630 640 650
TSTSVFVDGL LSEPGDETLV MTVFGHISFR SDWELVKVDF RPSFPRPCVE
660 670 680 690 700
DDYSSWDLTD LQGDHCIMGQ QRSYRKRKST SWCVKGRSFT SALTSRVCKC
710 720 730 740 750
RDSDFLCDYG FERSSSSEST VNKCSANFWF NPLSPPEDCV LGQTYTSSLG
760 770 780 790 800
YRKVVSNVCE GGVDLQQSPV QLQCPLQAPR GLQVSIRGEA VAVRPREDVL
810 820 830 840 850
FVVRQEQGDV LTTKYQVDLG DGFKAMYVNL TLTGEPIRHH YESPGIYRVS
860 870 880 890 900
VRAENMAGHD EAVLFVQVNS PLQALYLEVV PVIGINQEVN LTAVLLPLNP
910 920 930 940 950
NLTVFYWWIG HSLQPLLSLD NSVTTRFTDA GDVRVTVQAA CGNSVLQDSR
960 970 980 990 1000
LVRVLDQFQV VPLQFSRDLD TFNPNTPEWR EDVGLVVTRL LSKETSIPEE
1010 1020 1030 1040 1050
LLVTVVKPGL PTIADLYVLL PPPRPTRKRS LTSDKRLAAV QQALNSHRIS
1060 1070 1080 1090 1100
FILRGGLRVL VELRDTDAGP QRPGGSGGYW AVVVLFVIGL FAVGAFILYK
1110 1120 1130 1140 1150
FKRKRPGRTV YAQMHNEKEQ EMTSPVSHSE DAQSAMQGNH SGVVLSINSR

EMHSYLVG
Length:1,158
Mass (Da):128,825
Last modified:July 22, 2015 - v3
Checksum:i13E270F0F8D5B988
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07015838 Genomic DNA. No translation available.
AABR07015839 Genomic DNA. No translation available.
AABR07015840 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000009960; ENSRNOP00000009960; ENSRNOG00000007033.

Similar proteinsi

Entry informationi

Entry nameiD3ZW09_RAT
AccessioniPrimary (citable) accession number: D3ZW09
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: November 22, 2017
This is version 63 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported