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Protein

Prostamide/prostaglandin F synthase

Gene

Fam213b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reduction of prostaglandin-ethanolamide H2 (prostamide H2) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H2 to prostaglandin F(2alpha) (By similarity).By similarity

Catalytic activityi

Thioredoxin + prostaglandin H2 = thioredoxin disulfide + prostaglandin F(2-alpha).

GO - Molecular functioni

  • antioxidant activity Source: GO_Central
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: UniProtKB
  • prostaglandin-F synthase activity Source: UniProtKB

GO - Biological processi

  • oxidation-reduction process Source: GO_Central
  • prostaglandin biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Prostamide/prostaglandin F synthase (EC:1.11.1.20)
Short name:
Prostamide/PG F synthase
Short name:
Prostamide/PGF synthase
Gene namesi
Name:Fam213b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1308251. Fam213b.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB-SubCell
  • endoplasmic reticulum Source: UniProtKB
  • myelin sheath Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004069691 – 201Prostamide/prostaglandin F synthaseAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD3ZVR7.
PeptideAtlasiD3ZVR7.
PRIDEiD3ZVR7.

PTM databases

iPTMnetiD3ZVR7.
PhosphoSitePlusiD3ZVR7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013468.
GenevisibleiD3ZVR7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018453.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4498. Eukaryota.
ENOG410YFY9. LUCA.
GeneTreeiENSGT00530000063724.
InParanoidiD3ZVR7.
KOiK15717.
OMAiDLGFKRY.
OrthoDBiEOG091G0WTG.
PhylomeDBiD3ZVR7.
TreeFamiTF313804.

Family and domain databases

InterProiView protein in InterPro
IPR032801. FAM213/AAED1.
IPR012336. Thioredoxin-like_fold.
PANTHERiPTHR28630. PTHR28630. 1 hit.
PfamiView protein in Pfam
PF13911. AhpC-TSA_2. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZVR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLDLGRVG ACVLKHAVTG EAVELRSLWQ EKACVVAGLR RFGCMVCRWI
60 70 80 90 100
AQDLSNLRGI LDQNDVRLVG IGPEALGLQE FLDGGYFSGE LYLDESKQIY
110 120 130 140 150
KELGFKRYNS LSILPAALGK PVRDVASKAK AVGIQGNLSG DLLQSGGLLV
160 170 180 190 200
VSKGGDRVLL HFIQSSPGDY VPQENILQAL GISAEVCSSK PPQCDEEVCG

R
Length:201
Mass (Da):21,607
Last modified:April 20, 2010 - v1
Checksum:iD8FC444C21207494
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473968 Genomic DNA. Translation: EDL81278.1.
RefSeqiNP_001102167.1. NM_001108697.1.
UniGeneiRn.27527.

Genome annotation databases

EnsembliENSRNOT00000018453; ENSRNOP00000018453; ENSRNOG00000013468.
GeneIDi362676.
KEGGirno:362676.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPGFS_RAT
AccessioniPrimary (citable) accession number: D3ZVR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 20, 2010
Last modified: June 7, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families