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D3ZVH5

- D3ZVH5_RAT

UniProt

D3ZVH5 - D3ZVH5_RAT

Protein
Submitted name:

Protein Mdm2

Gene

Mdm2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. p53 binding Source: RGD
    2. peroxisome proliferator activated receptor binding Source: RGD
    3. protein binding Source: RGD
    4. ubiquitin-protein transferase activity Source: RGD
    5. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. cellular response to acid chemical Source: RGD
    2. cellular response to alkaloid Source: RGD
    3. cellular response to antibiotic Source: RGD
    4. cellular response to estrogen stimulus Source: RGD
    5. cellular response to growth factor stimulus Source: RGD
    6. cellular response to hydrogen peroxide Source: RGD
    7. cellular response to hypoxia Source: Ensembl
    8. cellular response to organic cyclic compound Source: RGD
    9. cellular response to organic substance Source: RGD
    10. cellular response to peptide hormone stimulus Source: RGD
    11. cellular response to UV-C Source: RGD
    12. cellular response to vitamin B1 Source: RGD
    13. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Ensembl
    14. establishment of protein localization Source: Ensembl
    15. negative regulation of apoptotic process Source: RGD
    16. negative regulation of cell cycle arrest Source: InterPro
    17. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
    18. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
    19. negative regulation of gene expression Source: RGD
    20. negative regulation of protein processing Source: RGD
    21. negative regulation of transcription, DNA-templated Source: RGD
    22. negative regulation of transcription from RNA polymerase II promoter Source: InterPro
    23. peptidyl-lysine modification Source: Ensembl
    24. positive regulation of gene expression Source: RGD
    25. positive regulation of mitotic cell cycle Source: Ensembl
    26. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
    27. positive regulation of protein export from nucleus Source: RGD
    28. protein complex assembly Source: Ensembl
    29. protein destabilization Source: Ensembl
    30. protein localization to nucleus Source: Ensembl
    31. protein ubiquitination Source: RGD
    32. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
    33. response to carbohydrate Source: RGD
    34. response to cocaine Source: RGD
    35. response to drug Source: RGD
    36. response to ether Source: RGD
    37. response to iron ion Source: RGD
    38. response to magnesium ion Source: RGD
    39. response to morphine Source: RGD
    40. response to steroid hormone Source: RGD
    41. response to toxic substance Source: RGD
    42. traversing start control point of mitotic cell cycle Source: Ensembl

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_203770. Oxidative Stress Induced Senescence.
    REACT_207379. Stabilization of p53.
    REACT_215142. Oncogene Induced Senescence.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Mdm2Imported
    Submitted name:
    Transformed mouse 3T3 cell double minute 2 homolog (Mouse) (Predicted), isoform CRA_bImported
    Gene namesi
    Name:Mdm2Imported
    Synonyms:Mdm2_predictedImported
    ORF Names:rCG_48669Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi1305332. Mdm2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. nuclear body Source: Ensembl
    3. nucleolus Source: Ensembl
    4. nucleus Source: RGD
    5. plasma membrane Source: RGD
    6. protein complex Source: Ensembl
    7. synapse Source: RGD

    Family & Domainsi

    Keywords - Domaini

    Zinc-fingerUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00530000063539.
    KOiK06643.
    OMAiLCVIREI.
    OrthoDBiEOG7RRF7T.

    Family and domain databases

    Gene3Di1.10.245.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR015459. MDM2_E3_ligase.
    IPR016495. p53_neg-reg_MDM_2/4.
    IPR003121. SWIB_MDM2_domain.
    IPR001876. Znf_RanBP2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PANTHERiPTHR10360:SF11. PTHR10360:SF11. 1 hit.
    PfamiPF02201. SWIB. 1 hit.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006748. p53_MDM_2/4. 1 hit.
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF47592. SSF47592. 2 hits.
    PROSITEiPS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3ZVH5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCNTNMSVST EGAAGTSQIP ASEQETLIIF YIGQYIMTKR LYDEKQQHIV    50
    YCSNDLLGDV FGVPSFSVKE HRKIYAMIYR NLVVVSQQDS GTSPSESRCQ 100
    PEGGSDLKDP VQASQEEKPS SSDVVSRPST SSRRRAISET EENTDELPGE 150
    RQRKRHRALS FDESLGLCVL REICCERSSS SEATDTPSHQ DLDDGVSDHS 200
    ADCLDQDSVS DQFSVEFEVE SLDSEDYSLS DEGHELSDED DEVYRVTVYQ 250
    AGESDADSFE GDPEISLADY WKCTSCNEMN PPLPSHCNRC WTLRENWLPD 300
    DKGKDKVEIS EKAKLESSDQ AEEGLDVPDG KKVTEDDAKE SSAEDSEEKV 350
    AQMLLSQESD DYSQPSTSSS IVYSSQESGK ELKEDTQDKE ESMESSFSLN 400
    AIEPCVICQG RPKNGCIVHG KTGHLMSCFT CAKKLKKRNK PCPVCRQPIQ 450
    MIVLTYFN 458
    Length:458
    Mass (Da):51,051
    Last modified:April 20, 2010 - v1
    Checksum:iA521BF918BA6E926
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06049829 Genomic DNA. No translation available.
    CH473960 Genomic DNA. Translation: EDM16616.1.
    CH473960 Genomic DNA. Translation: EDM16617.1.
    RefSeqiNP_001101569.1. NM_001108099.1.
    UniGeneiRn.91829.

    Genome annotation databases

    EnsembliENSRNOT00000066767; ENSRNOP00000063449; ENSRNOG00000006304.
    GeneIDi314856.
    KEGGirno:314856.
    UCSCiRGD:1305332. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06049829 Genomic DNA. No translation available.
    CH473960 Genomic DNA. Translation: EDM16616.1 .
    CH473960 Genomic DNA. Translation: EDM16617.1 .
    RefSeqi NP_001101569.1. NM_001108099.1.
    UniGenei Rn.91829.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000066767 ; ENSRNOP00000063449 ; ENSRNOG00000006304 .
    GeneIDi 314856.
    KEGGi rno:314856.
    UCSCi RGD:1305332. rat.

    Organism-specific databases

    CTDi 4193.
    RGDi 1305332. Mdm2.

    Phylogenomic databases

    GeneTreei ENSGT00530000063539.
    KOi K06643.
    OMAi LCVIREI.
    OrthoDBi EOG7RRF7T.

    Enzyme and pathway databases

    Reactomei REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_203770. Oxidative Stress Induced Senescence.
    REACT_207379. Stabilization of p53.
    REACT_215142. Oncogene Induced Senescence.

    Miscellaneous databases

    NextBioi 668312.

    Family and domain databases

    Gene3Di 1.10.245.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR015459. MDM2_E3_ligase.
    IPR016495. p53_neg-reg_MDM_2/4.
    IPR003121. SWIB_MDM2_domain.
    IPR001876. Znf_RanBP2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    PANTHERi PTHR10360:SF11. PTHR10360:SF11. 1 hit.
    Pfami PF02201. SWIB. 1 hit.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006748. p53_MDM_2/4. 1 hit.
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47592. SSF47592. 2 hits.
    PROSITEi PS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD3ZVH5_RAT
    AccessioniPrimary (citable) accession number: D3ZVH5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3