Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase Mdm2

Gene

Mdm2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.UniRule annotation

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase activity Source: UniProtKB
  • ubiquitin-protein transferase activity Source: RGD

GO - Biological processi

  • cellular response to alkaloid Source: RGD
  • cellular response to antibiotic Source: RGD
  • cellular response to estrogen stimulus Source: RGD
  • cellular response to growth factor stimulus Source: RGD
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to organic cyclic compound Source: RGD
  • cellular response to organic substance Source: RGD
  • cellular response to peptide hormone stimulus Source: RGD
  • cellular response to UV-C Source: RGD
  • cellular response to vitamin B1 Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cell cycle arrest Source: InterPro
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of neuron projection development Source: RGD
  • negative regulation of protein processing Source: RGD
  • negative regulation of transcription, DNA-templated Source: RGD
  • negative regulation of transcription by RNA polymerase II Source: InterPro
  • positive regulation of gene expression Source: RGD
  • positive regulation of protein export from nucleus Source: RGD
  • positive regulation of vascular associated smooth muscle cell migration Source: RGD
  • positive regulation of vascular smooth muscle cell proliferation Source: RGD
  • protein ubiquitination Source: UniProtKB
  • response to cocaine Source: RGD
  • response to drug Source: RGD
  • response to ether Source: RGD
  • response to formaldehyde Source: RGD
  • response to iron ion Source: RGD
  • response to magnesium ion Source: RGD
  • response to morphine Source: RGD
  • response to steroid hormone Source: RGD
  • response to toxic substance Source: RGD
  • response to water-immersion restraint stress Source: RGD

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-198323 AKT phosphorylates targets in the cytosol
R-RNO-2559580 Oxidative Stress Induced Senescence
R-RNO-2559585 Oncogene Induced Senescence
R-RNO-399719 Trafficking of AMPA receptors
R-RNO-5689880 Ub-specific processing proteases
R-RNO-6804756 Regulation of TP53 Activity through Phosphorylation
R-RNO-6804757 Regulation of TP53 Degradation
R-RNO-6804760 Regulation of TP53 Activity through Methylation
R-RNO-69541 Stabilization of p53
R-RNO-8941858 Regulation of RUNX3 expression and activity

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase Mdm2UniRule annotation (EC:2.3.2.27UniRule annotation)
Gene namesi
Name:Mdm2Imported
Synonyms:Mdm2_predictedImported
ORF Names:rCG_48669Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305332 Mdm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000006304
ExpressionAtlasiD3ZVH5 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063449

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini267 – 296RanBP2-typeInterPro annotationAdd BLAST30
Domaini405 – 446RING-typeInterPro annotationAdd BLAST42

Sequence similaritiesi

Belongs to the MDM2/MDM4 family.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGXG Eukaryota
ENOG41125MP LUCA
GeneTreeiENSGT00530000063539
KOiK06643

Family and domain databases

Gene3Di1.10.245.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028340 Mdm2
IPR015459 MDM2_E3_ligase
IPR016495 p53_neg-reg_MDM_2/4
IPR036885 SWIB_MDM2_dom_sf
IPR003121 SWIB_MDM2_domain
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR13844:SF15 PTHR13844:SF15, 2 hits
PfamiView protein in Pfam
PF02201 SWIB, 1 hit
PF00641 zf-RanBP, 1 hit
PIRSFiPIRSF500700 MDM2, 2 hits
PIRSF006748 p53_MDM_2/4, 2 hits
SUPFAMiSSF47592 SSF47592, 2 hits
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZVH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCNTNMSVST EGAAGTSQIP ASEQETLIIF YIGQYIMTKR LYDEKQQHIV
60 70 80 90 100
YCSNDLLGDV FGVPSFSVKE HRKIYAMIYR NLVVVSQQDS GTSPSESRCQ
110 120 130 140 150
PEGGSDLKDP VQASQEEKPS SSDVVSRPST SSRRRAISET EENTDELPGE
160 170 180 190 200
RQRKRHRALS FDESLGLCVL REICCERSSS SEATDTPSHQ DLDDGVSDHS
210 220 230 240 250
ADCLDQDSVS DQFSVEFEVE SLDSEDYSLS DEGHELSDED DEVYRVTVYQ
260 270 280 290 300
AGESDADSFE GDPEISLADY WKCTSCNEMN PPLPSHCNRC WTLRENWLPD
310 320 330 340 350
DKGKDKVEIS EKAKLESSDQ AEEGLDVPDG KKVTEDDAKE SSAEDSEEKV
360 370 380 390 400
AQMLLSQESD DYSQPSTSSS IVYSSQESGK ELKEDTQDKE ESMESSFSLN
410 420 430 440 450
AIEPCVICQG RPKNGCIVHG KTGHLMSCFT CAKKLKKRNK PCPVCRQPIQ

MIVLTYFN
Length:458
Mass (Da):51,051
Last modified:April 20, 2010 - v1
Checksum:iA521BF918BA6E926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07057209 Genomic DNA No translation available.
CH473960 Genomic DNA Translation: EDM16616.1
CH473960 Genomic DNA Translation: EDM16617.1
RefSeqiNP_001101569.1, NM_001108099.1
UniGeneiRn.91829

Genome annotation databases

EnsembliENSRNOT00000066767; ENSRNOP00000063449; ENSRNOG00000006304
GeneIDi314856
KEGGirno:314856
UCSCiRGD:1305332 rat

Similar proteinsi

Entry informationi

Entry nameiD3ZVH5_RAT
AccessioniPrimary (citable) accession number: D3ZVH5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health