D3ZVH5 (D3ZVH5_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Mdm2 Ensembl ENSRNOP00000063449

Submitted name:
Transformed mouse 3T3 cell double minute 2 homolog (Mouse) (Predicted), isoform CRA_b EMBL EDM16616.1

Gene names

Name:	Mdm2 Ensembl ENSRNOP00000063449 RGD 1305332
Synonyms:	Mdm2_predicted EMBL EDM16616.1
ORF Names:	rCG_48669 EMBL EDM16616.1

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000063449

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Domain	Zinc-finger RuleBase RU000353
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Inferred from electronic annotation. Source: Compara cellular response to UV-C Inferred from expression pattern PubMed 14558917. Source: RGD cellular response to acid Inferred from expression pattern PubMed 16598789. Source: RGD cellular response to alkaloid Inferred from expression pattern PubMed 19136059. Source: RGD cellular response to antibiotic Inferred from expression pattern PubMed 18469520. Source: RGD cellular response to estrogen stimulus Inferred from expression pattern PubMed 14667141. Source: RGD cellular response to growth factor stimulus Inferred from expression pattern PubMed 16091747. Source: RGD cellular response to hydrogen peroxide Inferred from expression pattern PubMed 19638633. Source: RGD cellular response to hypoxia Inferred from electronic annotation. Source: Compara cellular response to peptide hormone stimulus Inferred from expression pattern PubMed 19850968. Source: RGD cellular response to vitamin B1 Inferred from expression pattern PubMed 15656374. Source: RGD establishment of protein localization Inferred from electronic annotation. Source: Compara negative regulation of DNA damage response, signal transduction by p53 class mediator Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from mutant phenotype PubMed 17881359. Source: RGD negative regulation of cell cycle arrest Inferred from electronic annotation. Source: InterPro negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from mutant phenotype PubMed 19850968. Source: RGD negative regulation of protein processing Inferred from mutant phenotype PubMed 19638633. Source: RGD negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara negative regulation of transcription, DNA-dependent Inferred from direct assay PubMed 19103650. Source: RGD peptidyl-lysine modification Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from mutant phenotype PubMed 19103650. Source: RGD positive regulation of mitotic cell cycle Inferred from electronic annotation. Source: Compara positive regulation of proteasomal ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: Compara positive regulation of protein export from nucleus Inferred from mutant phenotype PubMed 17881359. Source: RGD protein complex assembly Inferred from electronic annotation. Source: Compara protein destabilization Inferred from electronic annotation. Source: Compara protein localization to nucleus Inferred from electronic annotation. Source: Compara protein ubiquitination involved in ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: Compara response to carbohydrate stimulus Inferred from expression pattern PubMed 18045764. Source: RGD response to cocaine Inferred from expression pattern PubMed 14625023. Source: RGD response to drug Inferred from expression pattern PubMed 19136059. Source: RGD response to ether Inferred from expression pattern PubMed 16790648. Source: RGD response to iron ion Inferred from expression pattern PubMed 20019189. Source: RGD response to magnesium ion Inferred from expression pattern PubMed 15165363. Source: RGD response to morphine Inferred from expression pattern PubMed 14625023. Source: RGD traversing start control point of mitotic cell cycle Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from direct assay PubMed 19819240. Source: RGD nuclear body Inferred from electronic annotation. Source: Compara nucleolus Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay PubMed 17107963. Source: RGD plasma membrane Inferred from direct assay PubMed 14642282. Source: RGD protein complex Inferred from electronic annotation. Source: Compara synapse Inferred from direct assay PubMed 14642282. Source: RGD
Molecular_function	ubiquitin-protein ligase activity Inferred from mutant phenotype PubMed 16330492. Source: RGD zinc ion binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D3ZVH5 [UniParc]. Last modified April 20, 2010. Version 1. Checksum: A521BF918BA6E926	FASTA	458	51,051
	10 20 30 40 50 60 MCNTNMSVST EGAAGTSQIP ASEQETLIIF YIGQYIMTKR LYDEKQQHIV YCSNDLLGDV 70 80 90 100 110 120 FGVPSFSVKE HRKIYAMIYR NLVVVSQQDS GTSPSESRCQ PEGGSDLKDP VQASQEEKPS 130 140 150 160 170 180 SSDVVSRPST SSRRRAISET EENTDELPGE RQRKRHRALS FDESLGLCVL REICCERSSS 190 200 210 220 230 240 SEATDTPSHQ DLDDGVSDHS ADCLDQDSVS DQFSVEFEVE SLDSEDYSLS DEGHELSDED 250 260 270 280 290 300 DEVYRVTVYQ AGESDADSFE GDPEISLADY WKCTSCNEMN PPLPSHCNRC WTLRENWLPD 310 320 330 340 350 360 DKGKDKVEIS EKAKLESSDQ AEEGLDVPDG KKVTEDDAKE SSAEDSEEKV AQMLLSQESD 370 380 390 400 410 420 DYSQPSTSSS IVYSSQESGK ELKEDTQDKE ESMESSFSLN AIEPCVICQG RPKNGCIVHG 430 440 450 KTGHLMSCFT CAKKLKKRNK PCPVCRQPIQ MIVLTYFN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000063449.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM16616.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM16616.1.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000063449.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06049829 Genomic DNA. No translation available. CH473960 Genomic DNA. Translation: EDM16616.1. CH473960 Genomic DNA. Translation: EDM16617.1.
IPI	IPI00948520.
RefSeq	NP_001101569.1. NM_001108099.1.
UniGene	Rn.91829.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000066767; ENSRNOP00000063449; ENSRNOG00000006304.
GeneID	314856.
KEGG	rno:314856.
UCSC	RGD:1305332. rat.
Organism-specific databases
CTD	4193.
RGD	1305332. Mdm2.
Phylogenomic databases
GeneTree	ENSGT00530000063539.
KO	K06643.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR015459. MDM2_E3_ligase. IPR016495. p53_neg-reg_MDM_2/4. IPR003121. SWIB_MDM2_domain. IPR001876. Znf_RanBP2. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
PANTHER	PTHR10360:SF9. PTHR10360:SF9. 1 hit.
Pfam	PF02201. SWIB. 1 hit. PF00641. zf-RanBP. 1 hit. [Graphical view]
PIRSF	PIRSF006748. p53_MDM_2/4. 1 hit.
SMART	SM00184. RING. 1 hit. [Graphical view]
SUPFAM	SSF47592. MDM2. 2 hits.
PROSITE	PS01358. ZF_RANBP2_1. 1 hit. PS50199. ZF_RANBP2_2. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	668312.

Entry information

Entry name

D3ZVH5_RAT

Accession

Primary (citable) accession number: D3ZVH5

Entry history

Integrated into UniProtKB/TrEMBL:	April 20, 2010
Last sequence update:	April 20, 2010
Last modified:	April 3, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)