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Protein
Submitted name:

MDM2 proto-oncogene

Gene

Mdm2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-198323. AKT phosphorylates targets in the cytosol.
R-RNO-2559580. Oxidative Stress Induced Senescence.
R-RNO-2559585. Oncogene Induced Senescence.
R-RNO-399719. Trafficking of AMPA receptors.
R-RNO-5689880. Ub-specific processing proteases.
R-RNO-6804756. Regulation of TP53 Activity through Phosphorylation.
R-RNO-6804757. Regulation of TP53 Degradation.
R-RNO-6804760. Regulation of TP53 Activity through Methylation.
R-RNO-69541. Stabilization of p53.
R-RNO-8941858. Regulation of RUNX3 expression and activity.

Names & Taxonomyi

Protein namesi
Submitted name:
MDM2 proto-oncogeneImported
Submitted name:
Transformed mouse 3T3 cell double minute 2 homolog (Mouse) (Predicted), isoform CRA_bImported
Gene namesi
Name:Mdm2Imported
Synonyms:Mdm2_predictedImported
ORF Names:rCG_48669Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305332. Mdm2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000006304.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063449.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini267 – 296RanBP2-typeInterPro annotationAdd BLAST30
Domaini405 – 446RING-typeInterPro annotationAdd BLAST42

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGXG. Eukaryota.
ENOG41125MP. LUCA.
GeneTreeiENSGT00530000063539.
KOiK06643.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR028340. Mdm2.
IPR015459. MDM2_E3_ligase.
IPR016495. p53_neg-reg_MDM_2/4.
IPR036885. SWIB_MDM2_dom_sf.
IPR003121. SWIB_MDM2_domain.
IPR001876. Znf_RanBP2.
IPR036443. Znf_RanBP2_sf.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR13844:SF15. PTHR13844:SF15. 2 hits.
PfamiView protein in Pfam
PF02201. SWIB. 1 hit.
PF00641. zf-RanBP. 1 hit.
PIRSFiPIRSF500700. MDM2. 2 hits.
PIRSF006748. p53_MDM_2/4. 2 hits.
SUPFAMiSSF47592. SSF47592. 2 hits.
SSF90209. SSF90209. 1 hit.
PROSITEiView protein in PROSITE
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZVH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCNTNMSVST EGAAGTSQIP ASEQETLIIF YIGQYIMTKR LYDEKQQHIV
60 70 80 90 100
YCSNDLLGDV FGVPSFSVKE HRKIYAMIYR NLVVVSQQDS GTSPSESRCQ
110 120 130 140 150
PEGGSDLKDP VQASQEEKPS SSDVVSRPST SSRRRAISET EENTDELPGE
160 170 180 190 200
RQRKRHRALS FDESLGLCVL REICCERSSS SEATDTPSHQ DLDDGVSDHS
210 220 230 240 250
ADCLDQDSVS DQFSVEFEVE SLDSEDYSLS DEGHELSDED DEVYRVTVYQ
260 270 280 290 300
AGESDADSFE GDPEISLADY WKCTSCNEMN PPLPSHCNRC WTLRENWLPD
310 320 330 340 350
DKGKDKVEIS EKAKLESSDQ AEEGLDVPDG KKVTEDDAKE SSAEDSEEKV
360 370 380 390 400
AQMLLSQESD DYSQPSTSSS IVYSSQESGK ELKEDTQDKE ESMESSFSLN
410 420 430 440 450
AIEPCVICQG RPKNGCIVHG KTGHLMSCFT CAKKLKKRNK PCPVCRQPIQ

MIVLTYFN
Length:458
Mass (Da):51,051
Last modified:April 20, 2010 - v1
Checksum:iA521BF918BA6E926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07057209 Genomic DNA. No translation available.
CH473960 Genomic DNA. Translation: EDM16616.1.
CH473960 Genomic DNA. Translation: EDM16617.1.
RefSeqiNP_001101569.1. NM_001108099.1.
UniGeneiRn.91829.

Genome annotation databases

EnsembliENSRNOT00000066767; ENSRNOP00000063449; ENSRNOG00000006304.
GeneIDi314856.
KEGGirno:314856.
UCSCiRGD:1305332. rat.

Similar proteinsi

Entry informationi

Entry nameiD3ZVH5_RAT
AccessioniPrimary (citable) accession number: D3ZVH5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 22, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported