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D3ZVH5

- D3ZVH5_RAT

UniProt

D3ZVH5 - D3ZVH5_RAT

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Protein
Submitted name: Protein Mdm2
Gene
Mdm2, Mdm2_predicted, rCG_48669
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. p53 binding Source: RGD
  2. peroxisome proliferator activated receptor binding Source: RGD
  3. protein binding Source: RGD
  4. ubiquitin-protein transferase activity Source: RGD
  5. zinc ion binding Source: Ensembl

GO - Biological processi

  1. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Ensembl
  2. cellular response to UV-C Source: RGD
  3. cellular response to acid Source: RGD
  4. cellular response to alkaloid Source: RGD
  5. cellular response to antibiotic Source: RGD
  6. cellular response to estrogen stimulus Source: RGD
  7. cellular response to growth factor stimulus Source: RGD
  8. cellular response to hydrogen peroxide Source: RGD
  9. cellular response to hypoxia Source: Ensembl
  10. cellular response to organic cyclic compound Source: RGD
  11. cellular response to organic substance Source: RGD
  12. cellular response to peptide hormone stimulus Source: RGD
  13. cellular response to vitamin B1 Source: RGD
  14. establishment of protein localization Source: Ensembl
  15. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
  16. negative regulation of apoptotic process Source: RGD
  17. negative regulation of cell cycle arrest Source: InterPro
  18. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  19. negative regulation of gene expression Source: RGD
  20. negative regulation of protein processing Source: RGD
  21. negative regulation of transcription from RNA polymerase II promoter Source: InterPro
  22. negative regulation of transcription, DNA-templated Source: RGD
  23. peptidyl-lysine modification Source: Ensembl
  24. positive regulation of gene expression Source: RGD
  25. positive regulation of mitotic cell cycle Source: Ensembl
  26. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  27. positive regulation of protein export from nucleus Source: RGD
  28. protein complex assembly Source: Ensembl
  29. protein destabilization Source: Ensembl
  30. protein localization to nucleus Source: Ensembl
  31. protein ubiquitination Source: RGD
  32. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
  33. response to carbohydrate Source: RGD
  34. response to cocaine Source: RGD
  35. response to drug Source: RGD
  36. response to ether Source: RGD
  37. response to iron ion Source: RGD
  38. response to magnesium ion Source: RGD
  39. response to morphine Source: RGD
  40. response to steroid hormone Source: RGD
  41. response to toxic substance Source: RGD
  42. traversing start control point of mitotic cell cycle Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_203770. Oxidative Stress Induced Senescence.
REACT_207379. Stabilization of p53.
REACT_215142. Oncogene Induced Senescence.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Mdm2Imported
Submitted name:
Transformed mouse 3T3 cell double minute 2 homolog (Mouse) (Predicted), isoform CRA_bImported
Gene namesi
Name:Mdm2Imported
Synonyms:Mdm2_predictedImported
ORF Names:rCG_48669Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi1305332. Mdm2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
  2. nuclear body Source: Ensembl
  3. nucleolus Source: Ensembl
  4. nucleus Source: RGD
  5. plasma membrane Source: RGD
  6. protein complex Source: Ensembl
  7. synapse Source: RGD
Complete GO annotation...

Family & Domainsi

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063539.
KOiK06643.
OMAiLCVIREI.
OrthoDBiEOG7RRF7T.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR015459. MDM2_E3_ligase.
IPR016495. p53_neg-reg_MDM_2/4.
IPR003121. SWIB_MDM2_domain.
IPR001876. Znf_RanBP2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10360:SF11. PTHR10360:SF11. 1 hit.
PfamiPF02201. SWIB. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
PIRSFiPIRSF006748. p53_MDM_2/4. 1 hit.
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF47592. SSF47592. 2 hits.
PROSITEiPS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZVH5-1 [UniParc]FASTAAdd to Basket

« Hide

MCNTNMSVST EGAAGTSQIP ASEQETLIIF YIGQYIMTKR LYDEKQQHIV    50
YCSNDLLGDV FGVPSFSVKE HRKIYAMIYR NLVVVSQQDS GTSPSESRCQ 100
PEGGSDLKDP VQASQEEKPS SSDVVSRPST SSRRRAISET EENTDELPGE 150
RQRKRHRALS FDESLGLCVL REICCERSSS SEATDTPSHQ DLDDGVSDHS 200
ADCLDQDSVS DQFSVEFEVE SLDSEDYSLS DEGHELSDED DEVYRVTVYQ 250
AGESDADSFE GDPEISLADY WKCTSCNEMN PPLPSHCNRC WTLRENWLPD 300
DKGKDKVEIS EKAKLESSDQ AEEGLDVPDG KKVTEDDAKE SSAEDSEEKV 350
AQMLLSQESD DYSQPSTSSS IVYSSQESGK ELKEDTQDKE ESMESSFSLN 400
AIEPCVICQG RPKNGCIVHG KTGHLMSCFT CAKKLKKRNK PCPVCRQPIQ 450
MIVLTYFN 458
Length:458
Mass (Da):51,051
Last modified:April 20, 2010 - v1
Checksum:iA521BF918BA6E926
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06049829 Genomic DNA. No translation available.
CH473960 Genomic DNA. Translation: EDM16616.1.
CH473960 Genomic DNA. Translation: EDM16617.1.
RefSeqiNP_001101569.1. NM_001108099.1.
UniGeneiRn.91829.

Genome annotation databases

EnsembliENSRNOT00000066767; ENSRNOP00000063449; ENSRNOG00000006304.
GeneIDi314856.
KEGGirno:314856.
UCSCiRGD:1305332. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06049829 Genomic DNA. No translation available.
CH473960 Genomic DNA. Translation: EDM16616.1 .
CH473960 Genomic DNA. Translation: EDM16617.1 .
RefSeqi NP_001101569.1. NM_001108099.1.
UniGenei Rn.91829.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000066767 ; ENSRNOP00000063449 ; ENSRNOG00000006304 .
GeneIDi 314856.
KEGGi rno:314856.
UCSCi RGD:1305332. rat.

Organism-specific databases

CTDi 4193.
RGDi 1305332. Mdm2.

Phylogenomic databases

GeneTreei ENSGT00530000063539.
KOi K06643.
OMAi LCVIREI.
OrthoDBi EOG7RRF7T.

Enzyme and pathway databases

Reactomei REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_203770. Oxidative Stress Induced Senescence.
REACT_207379. Stabilization of p53.
REACT_215142. Oncogene Induced Senescence.

Miscellaneous databases

NextBioi 668312.

Family and domain databases

Gene3Di 1.10.245.10. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR015459. MDM2_E3_ligase.
IPR016495. p53_neg-reg_MDM_2/4.
IPR003121. SWIB_MDM2_domain.
IPR001876. Znf_RanBP2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR10360:SF11. PTHR10360:SF11. 1 hit.
Pfami PF02201. SWIB. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view ]
PIRSFi PIRSF006748. p53_MDM_2/4. 1 hit.
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF47592. SSF47592. 2 hits.
PROSITEi PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD3ZVH5_RAT
AccessioniPrimary (citable) accession number: D3ZVH5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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