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Protein

Histone deacetylase

Gene

Hdac6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • axonal transport of mitochondrion Source: RGD
  • cellular response to oxidative stress Source: RGD
  • cellular response to parathyroid hormone stimulus Source: RGD
  • negative regulation of axon extension involved in axon guidance Source: RGD
  • negative regulation of neuron projection development Source: RGD
  • negative regulation of protein acetylation Source: RGD
  • neuron differentiation Source: RGD
  • positive regulation of cholangiocyte proliferation Source: RGD
  • positive regulation of dendrite morphogenesis Source: RGD
  • positive regulation of oxidative stress-induced neuron death Source: RGD
  • positive regulation of synaptic transmission, glutamatergic Source: RGD
  • positive regulation of tubulin deacetylation Source: RGD
  • regulation of microtubule cytoskeleton organization Source: RGD
  • regulation of mitochondrion organization Source: RGD
  • regulation of protein phosphorylation Source: RGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • response to amphetamine Source: RGD
  • response to corticosterone Source: RGD
  • response to dexamethasone Source: RGD
  • response to immobilization stress Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulatorSAAS annotation, HydrolaseSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-3371511. HSF1 activation.
R-RNO-5617833. Cilium Assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseSAAS annotation (EC:3.5.1.98SAAS annotation)
Gene namesi
Name:Hdac6Imported
Synonyms:LOC100911205Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi619981. Hdac6.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

  • axon Source: RGD
  • axon cytoplasm Source: GOC
  • centrosome Source: RGD
  • nucleus Source: UniProtKB-SubCell

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiD3ZVD8.
PeptideAtlasiD3ZVD8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000047281.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063689.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1071 – 1132UBP-typeInterPro annotationAdd BLAST62

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062809.
OMAiFDCAVLA.
OrthoDBiEOG091G0210.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
PRINTSiPR01270. HDASUPER.
SMARTiView protein in SMART
SM00290. ZnF_UBP. 1 hit.
PROSITEiView protein in PROSITE
PS50271. ZF_UBP. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZVD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTGQDSST RQRKSRHNPQ SPLQDSSATL KRGGKKGAVP HSSPNLAEVK
60 70 80 90 100
KKGKMKKLSQ PAEEDLIVGL QGLDLNSETR VPVGTGLVFD EQLNDFHCLW
110 120 130 140 150
DDSFPENPER LHAIKEQLIL EGLLGRCVSF QARFAEKEEL MLVHSLEYID
160 170 180 190 200
LMETTQYMNE GELRVLAGTY DSVYLHPNSY SCACLATGSV LRLVDAVMGA
210 220 230 240 250
EIRNGMAVIR PPGHHAQRSL MDGYCMFNHL AVAARYAQKK HRIQRILIVD
260 270 280 290 300
WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTTGFGQGQ
310 320 330 340 350
GYTINVPWNQ VGMRDADYIA AFLHILLPVA FEFQPQLVLV AAGFDALHGD
360 370 380 390 400
PKVRQGEMSA TPAGFAHLTH FLMGLAGGKL ILSLEGGYNL HALAKGVSGS
410 420 430 440 450
LHTLLGDPCP MLESPVAPCA SAQTSISCTL EALEPFWEVL ERSVEPQDED
460 470 480 490 500
EVEGDMLEDE EEEGHWEATA LPMDTWPLLQ NRTGLVYDER MMSHCNLWDN
510 520 530 540 550
HHPETPQRIL RIMCHLEEVG LAARCLILPA RPALDSELLT CHSAEYVERL
560 570 580 590 600
RATEKMKTRD LHREGANFES IYICPSTFAC AQLATGAACR LVEAVLSGEV
610 620 630 640 650
LNGIAIVRPP GHHAEPDAAC GFCFFNSVAV AARHAQVIAG RALRILIVDW
660 670 680 690 700
DVHHGNGTQH IFEEDPSVLY VSLHRYDRGT FFPMGDEGAS SQVGRAAGTG
710 720 730 740 750
FTVNVPWNGP RMGDADYLAT WHRLVLPIAY EFNPELVLIS AGFDAAQGDP
760 770 780 790 800
LGGCQVTPEG YAHLTHLLMG LAGGRIILIL EGGYNLTSIS ESMAACTHSL
810 820 830 840 850
LGDPPPQLTS LRPPQSGALA SISEVIQVHR KYWRSLRLMK MEDKEERSSS
860 870 880 890 900
RLVIKKLPQS ASPVSAKGMT TPKGKVLEAG MRKPTAALPT KESTLGQAKA
910 920 930 940 950
KTAKALLAQG QSSEQAAKGT TLDLATSKDT VGGATTDQCA SVAATENSAN
960 970 980 990 1000
QTTSGEEASG ETESFGTSPS SNASKQTTGA SPLHGAAAQQ SPELGLSSTL
1010 1020 1030 1040 1050
ELSSEAQEVQ ESEEGLLGEA AGGQDMNSLM LTQGFGDFNT QDVFYAVTPL
1060 1070 1080 1090 1100
SWCPHLMAVC PIPAAGLDVS QPCKTCGSVQ ENWVCLTCYQ VYCSRYVNAH
1110 1120 1130 1140 1150
MVCHHEASEH PLVLSCVDLS TWCYLCQAYV HHEDLQDVKN AAHQNKFGEG

MPHLQ
Length:1,155
Mass (Da):125,878
Last modified:April 3, 2013 - v2
Checksum:iB0DEA1101E78B88F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073519 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000064924; ENSRNOP00000063689; ENSRNOG00000047281.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD3ZVD8_RAT
AccessioniPrimary (citable) accession number: D3ZVD8
Secondary accession number(s): F1LSE3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: June 7, 2017
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported