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Protein
Submitted name:

Cbl proto-oncogene

Gene

Cbl

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding Source: Ensembl
  • calcium ion binding Source: InterPro
  • ephrin receptor binding Source: Ensembl
  • epidermal growth factor receptor binding Source: RGD
  • phosphatidylinositol 3-kinase regulatory subunit binding Source: RGD
  • phosphotyrosine binding Source: InterPro
  • protein kinase binding Source: RGD
  • protein tyrosine kinase binding Source: RGD
  • receptor tyrosine kinase binding Source: GO_Central
  • SH3 domain binding Source: RGD
  • signal transducer activity Source: InterPro
  • ubiquitin protein ligase activity Source: RGD

GO - Biological processi

  • cellular response to DNA damage stimulus Source: RGD
  • cellular response to epidermal growth factor stimulus Source: RGD
  • cellular response to nerve growth factor stimulus Source: RGD
  • cellular response to oxygen-glucose deprivation Source: RGD
  • cellular response to platelet-derived growth factor stimulus Source: RGD
  • epidermal growth factor receptor signaling pathway Source: GO_Central
  • male gonad development Source: RGD
  • mast cell degranulation Source: RGD
  • negative regulation of apoptotic process Source: Ensembl
  • negative regulation of epidermal growth factor-activated receptor activity Source: GO_Central
  • negative regulation of neuron death Source: RGD
  • neuron death Source: RGD
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  • positive regulation of receptor-mediated endocytosis Source: Ensembl
  • protein monoubiquitination Source: RGD
  • protein polyubiquitination Source: RGD
  • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
  • proteolysis Source: GO_Central
  • response to activity Source: RGD
  • response to antibiotic Source: RGD
  • response to ethanol Source: RGD
  • response to gamma radiation Source: RGD
  • response to starvation Source: RGD
  • response to testosterone Source: RGD

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1295596. Spry regulation of FGF signaling.
R-RNO-1433559. Regulation of KIT signaling.
R-RNO-182971. EGFR downregulation.
R-RNO-2173789. TGF-beta receptor signaling activates SMADs.
R-RNO-5654726. Negative regulation of FGFR1 signaling.
R-RNO-5654727. Negative regulation of FGFR2 signaling.
R-RNO-5654732. Negative regulation of FGFR3 signaling.
R-RNO-5654733. Negative regulation of FGFR4 signaling.
R-RNO-6783589. Interleukin-6 family signaling.
R-RNO-6807004. Negative regulation of MET activity.
R-RNO-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.
R-RNO-912631. Regulation of signaling by CBL.
R-RNO-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Submitted name:
Cbl proto-oncogeneImported
Gene namesi
Name:CblImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1561386. Cbl.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • cytosol Source: Reactome
  • flotillin complex Source: Ensembl
  • focal adhesion Source: RGD
  • growth cone Source: RGD
  • membrane raft Source: RGD
  • nucleus Source: InterPro
  • perinuclear region of cytoplasm Source: RGD
  • plasma membrane Source: RGD

PTM / Processingi

Proteomic databases

PaxDbiD3ZV15.
PeptideAtlasiD3ZV15.
PRIDEiD3ZV15.

PTM databases

iPTMnetiD3ZV15.
PhosphoSitePlusiD3ZV15.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008444.
GenevisibleiD3ZV15. RN.

Interactioni

GO - Molecular functioni

  • cadherin binding Source: Ensembl
  • ephrin receptor binding Source: Ensembl
  • epidermal growth factor receptor binding Source: RGD
  • phosphatidylinositol 3-kinase regulatory subunit binding Source: RGD
  • phosphotyrosine binding Source: InterPro
  • protein kinase binding Source: RGD
  • protein tyrosine kinase binding Source: RGD
  • receptor tyrosine kinase binding Source: GO_Central
  • SH3 domain binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063226.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 350Cbl-PTB (Cbl-type phosphotyrosine-binding)InterPro annotationAdd BLAST305
Domaini380 – 419RING-typeInterPro annotationAdd BLAST40
Domaini864 – 903UBAInterPro annotationAdd BLAST40

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1785. Eukaryota.
ENOG410YDNH. LUCA.
GeneTreeiENSGT00390000011617.
InParanoidiD3ZV15.
KOiK04707.
OMAiCEHPKIK.
OrthoDBiEOG091G0GPE.
TreeFamiTF314210.

Family and domain databases

CDDicd00162. RING. 1 hit.
cd09920. SH2_Cbl-b_TKB. 1 hit.
Gene3Di1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR015940. UBA.
IPR009060. UBA-like.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiView protein in Pfam
PF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
PF00627. UBA. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
SM00165. UBA. 1 hit.
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF47473. SSF47473. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS51506. CBL_PTB. 1 hit.
PS50030. UBA. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZV15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNVKKSSG AGGSGSGGSG AGGLIGLMKD AFQPHHHHHH HLSPHPPCTV
60 70 80 90 100
DKKMVEKCWK LMDKVVRLCQ NPKLALKNSP PYILDLLPDT YQHLRTVLSR
110 120 130 140 150
YEGKMETLGE NEYFRVFMEN LMKKTKQTIS LFKEGKERMY EENSQPRRNL
160 170 180 190 200
TKLSLIFSHM LAELKGIFPS GLFQGDTFRI TKADAAEFWR KAFGEKTIVP
210 220 230 240 250
WKSFRQALHE VHPISSGLEA MALKSTIDLT CNDYISVFEF DIFTRLFQPW
260 270 280 290 300
SSLLRNWNSL AVTHPGYMAF LTYDEVKARL QKFIHKPGSY IFRLSCTRLG
310 320 330 340 350
QWAIGYVTAD GNILQTIPHN KPLFQALIDG FREGFYLFPD GRNQNPDLTG
360 370 380 390 400
LCEPTPQDHI KVTQEQYELY CEMGSTFQLC KICAENDKDV KIEPCGHLMC
410 420 430 440 450
TSCLTSWQES EGQGCPFCRC EIKGTEPIVV DPFDPRGSGS LLRQGAEGAP
460 470 480 490 500
SPNYDDDDDE RADDSLFMMK ELAGAKVERP SSPFSMAPQA SLPPVPPRLD
510 520 530 540 550
LLQQRAPVPA STSVLGTASK ASSSSLHKDK PLPIPPTLRD LPPPPPPDRP
560 570 580 590 600
YSVGTETRPQ RRPLPCTPGD CPSRDKLPPV PSSRPGDSWL SRPIPKVPVA
610 620 630 640 650
TPNPGDPWNG RELTNRHSLP FSLPSQMEPR ADVPRLGSTF SLDTSTTMNS
660 670 680 690 700
SPVAGPESEH PKIKPSSSAN AIYSLAARPL PVPKLPPGEQ GDSEEDTEYM
710 720 730 740 750
TPTSRPVGVQ KPEPKRPAET AQSSRACDCD QQIDSCTYEA MYNIQSQALS
760 770 780 790 800
VAENSACGEG NLATAHTSTG PEESENEDDG YDVPKPPVPA VLARRTLSDI
810 820 830 840 850
SNASSSFGWL SLDGEPTNFN EGSQVPERPP KPFPRRINSE RKASSYQQGG
860 870 880 890 900
GAMANPAAAA PSPQLSSEIE RLMSQGYSYQ DIQKALVIAH NNIEMAKNIL
910
REFVSISSPA HVAT
Length:914
Mass (Da):100,691
Last modified:April 20, 2010 - v1
Checksum:i6611E312B9E2C1B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112557 Genomic DNA. No translation available.
RefSeqiXP_001066453.2. XM_001066453.6.
XP_576396.3. XM_576396.7.
UniGeneiRn.232835.

Genome annotation databases

EnsembliENSRNOT00000067902; ENSRNOP00000063226; ENSRNOG00000008444.
GeneIDi500985.
KEGGirno:500985.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD3ZV15_RAT
AccessioniPrimary (citable) accession number: D3ZV15
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 5, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported