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D3ZUY8

- D3ZUY8_RAT

UniProt

D3ZUY8 - D3ZUY8_RAT

Protein
Submitted name:

Adaptor protein complex AP-2, alpha 1 subunit (Predicted)

Gene

Ap2a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: RGD
    2. protein C-terminus binding Source: RGD
    3. protein transporter activity Source: InterPro

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. vesicle-mediated transport Source: InterPro

    Keywords - Biological processi

    Protein transportSAAS annotation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198398. WNT5A-dependent internalization of FZD4.
    REACT_198830. MHC class II antigen presentation.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Adaptor protein complex AP-2, alpha 1 subunit (Predicted)Imported
    Submitted name:
    Protein Ap2a1Imported
    Gene namesi
    Name:Ap2a1Imported
    Synonyms:Ap2a1_predictedImported
    ORF Names:rCG_54084Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1306254. Ap2a1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: RGD
    2. basolateral plasma membrane Source: RGD
    3. clathrin adaptor complex Source: InterPro
    4. protein complex Source: RGD

    Keywords - Cellular componenti

    MembraneSAAS annotation

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00550000074757.
    KOiK11824.
    OMAiNYVGAGI.
    OrthoDBiEOG7GQXV2.
    TreeFamiTF300308.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    2.60.40.1030. 1 hit.
    3.30.310.30. 1 hit.
    InterProiIPR017104. AP2_complex_asu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR013038. Clathrin_a-adaptin_app_Ig-like.
    IPR003164. Clathrin_a-adaptin_app_sub_C.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view]
    PfamiPF01602. Adaptin_N. 1 hit.
    PF02296. Alpha_adaptin_C. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
    SMARTiSM00809. Alpha_adaptinC2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D3ZUY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL    50
    DGYSKKKYVC KLLFIFLLGH DIDFGHMEAV NLLSSNKYTE KQIGYLFISV 100
    LVNSNSELIR LINNAIKNDL ASRNPTFMCL ALHCIANVGS REMGEAFAAD 150
    IPRILVAGDS MDSVKQSAAL CLLRLYKASP DLVPMGEWTA RVVHLLNDQH 200
    MGVVTAAVSL ITCLCKKNPD DFKTCVSLAV SRLSRIVSSA STDLQDYTYY 250
    FVPAPWLSVK LLRLLQCYPP PEDAAVKGRL VECLETVLNK AQEPPKSKKV 300
    QHSNAKNAIL FETISLIIHY DSEPNLLVRA CNQLGQFLQH RETNLRYLAL 350
    ESMCTLASSE FSHEAVKTHI DTVINALKTE RDVSVRQRAA DLLYAMCDRS 400
    NAKQIVSEML RYLETADYAI REEIVLKVAI LAEKYAVDYS WYVDTILNLI 450
    RIAGDYVSEE VWYRVLQIVT NRDDVQGYAA KTVFEALQAP ACHENMVKVG 500
    GYILGEFGNL IAGDPRSSPP VQFSLLHSKF HLCSVATRAL LLSTYIKFIN 550
    LFPETKATIQ GVLRAGSQLR NADVELQQRA VEYLTLSSVA STDVLATVLE 600
    EMPPFPERES SILAKLKRKK GPGAASALDD SRRDTSSNDI NGGVEPTPSN 650
    VSTPSPSADL LGLRAAPPPA APPAPVGGNL LVDVFSDGPT AQPSLGPTPE 700
    EAFLSELEPP APESPMTLLA DPAPAADPGP EDIGPPIPEA DELLNKFVCK 750
    NSGVLFENQL LQIGVKSEFR QNLGRMYLFY GNKTSVQFQS FLPTVVHPGD 800
    LQTHLAVQTK RVAAQVDGGA QVQQVLNIEC LRDFLTPPLL SVRFRYGGTA 850
    QSLTLKLPVT INKFFQPTEM AAQDFFQRWK QLSLPLQEAQ KIFKANHPMD 900
    AEVTKAKLLG FGSALLDNVD PNPENFVGAG IIQTKALQVG CLLRLEPNAQ 950
    AQMYRLTLRT SKEPVSRHLC ELLAQQF 977
    Length:977
    Mass (Da):107,675
    Last modified:April 20, 2010 - v1
    Checksum:i5704048BEC825FDF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06004807 Genomic DNA. No translation available.
    AABR06004808 Genomic DNA. No translation available.
    CH473979 Genomic DNA. Translation: EDM07441.1.
    RefSeqiNP_001100981.1. NM_001107511.2.
    UniGeneiRn.162416.

    Genome annotation databases

    EnsembliENSRNOT00000020304; ENSRNOP00000020304; ENSRNOG00000026243.
    GeneIDi308578.
    KEGGirno:308578.
    UCSCiRGD:1306254. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06004807 Genomic DNA. No translation available.
    AABR06004808 Genomic DNA. No translation available.
    CH473979 Genomic DNA. Translation: EDM07441.1 .
    RefSeqi NP_001100981.1. NM_001107511.2.
    UniGenei Rn.162416.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000020304 ; ENSRNOP00000020304 ; ENSRNOG00000026243 .
    GeneIDi 308578.
    KEGGi rno:308578.
    UCSCi RGD:1306254. rat.

    Organism-specific databases

    CTDi 160.
    RGDi 1306254. Ap2a1.

    Phylogenomic databases

    GeneTreei ENSGT00550000074757.
    KOi K11824.
    OMAi NYVGAGI.
    OrthoDBi EOG7GQXV2.
    TreeFami TF300308.

    Enzyme and pathway databases

    Reactomei REACT_198398. WNT5A-dependent internalization of FZD4.
    REACT_198830. MHC class II antigen presentation.

    Miscellaneous databases

    NextBioi 659166.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    2.60.40.1030. 1 hit.
    3.30.310.30. 1 hit.
    InterProi IPR017104. AP2_complex_asu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR013038. Clathrin_a-adaptin_app_Ig-like.
    IPR003164. Clathrin_a-adaptin_app_sub_C.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view ]
    Pfami PF01602. Adaptin_N. 1 hit.
    PF02296. Alpha_adaptin_C. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037091. AP2_complex_alpha. 1 hit.
    SMARTi SM00809. Alpha_adaptinC2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD3ZUY8_RAT
    AccessioniPrimary (citable) accession number: D3ZUY8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3