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Protein
Submitted name:

Adaptor protein complex AP-2, alpha 1 subunit (Predicted)

Gene

Ap2a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein complex binding Source: RGD
  • protein C-terminus binding Source: RGD
  • protein kinase binding Source: Ensembl
  • protein transporter activity Source: InterPro

GO - Biological processi

Keywordsi

Biological processProtein transportSAAS annotation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-177504. Retrograde neurotrophin signalling.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-416993. Trafficking of GluR2-containing AMPA receptors.
R-RNO-437239. Recycling pathway of L1.
R-RNO-5099900. WNT5A-dependent internalization of FZD4.
R-RNO-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.
R-RNO-8866427. VLDLR internalisation and degradation.
R-RNO-8964038. LDL clearance.

Names & Taxonomyi

Protein namesi
Submitted name:
Adaptor protein complex AP-2, alpha 1 subunit (Predicted)Imported
Submitted name:
Adaptor-related protein complex 2, alpha 1 subunitImported
Gene namesi
Name:Ap2a1Imported
Synonyms:Ap2a1_predictedImported
ORF Names:rCG_54084Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1306254. Ap2a1.

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • basolateral plasma membrane Source: RGD
  • clathrin adaptor complex Source: InterPro
  • filopodium tip Source: Ensembl
  • protein complex Source: RGD

Keywords - Cellular componenti

MembraneSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000026243.

Interactioni

GO - Molecular functioni

  • protein complex binding Source: RGD
  • protein C-terminus binding Source: RGD
  • protein kinase binding Source: Ensembl

Protein-protein interaction databases

IntActiD3ZUY8. 1 interactor.
STRINGi10116.ENSRNOP00000020304.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini745 – 858Alpha_adaptinC2InterPro annotationAdd BLAST114

Phylogenomic databases

eggNOGiKOG1077. Eukaryota.
ENOG410XNQE. LUCA.
GeneTreeiENSGT00550000074757.
KOiK11824.
OMAiDFKTCIS.
OrthoDBiEOG091G01JZ.
TreeFamiTF300308.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR017104. AP2_complex_asu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR003164. Clathrin_a-adaptin_app_sub_C.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
PfamiView protein in Pfam
PF01602. Adaptin_N. 1 hit.
PF02296. Alpha_adaptin_C. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
SMARTiView protein in SMART
SM00809. Alpha_adaptinC2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZUY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL
60 70 80 90 100
DGYSKKKYVC KLLFIFLLGH DIDFGHMEAV NLLSSNKYTE KQIGYLFISV
110 120 130 140 150
LVNSNSELIR LINNAIKNDL ASRNPTFMCL ALHCIANVGS REMGEAFAAD
160 170 180 190 200
IPRILVAGDS MDSVKQSAAL CLLRLYKASP DLVPMGEWTA RVVHLLNDQH
210 220 230 240 250
MGVVTAAVSL ITCLCKKNPD DFKTCVSLAV SRLSRIVSSA STDLQDYTYY
260 270 280 290 300
FVPAPWLSVK LLRLLQCYPP PEDAAVKGRL VECLETVLNK AQEPPKSKKV
310 320 330 340 350
QHSNAKNAIL FETISLIIHY DSEPNLLVRA CNQLGQFLQH RETNLRYLAL
360 370 380 390 400
ESMCTLASSE FSHEAVKTHI DTVINALKTE RDVSVRQRAA DLLYAMCDRS
410 420 430 440 450
NAKQIVSEML RYLETADYAI REEIVLKVAI LAEKYAVDYS WYVDTILNLI
460 470 480 490 500
RIAGDYVSEE VWYRVLQIVT NRDDVQGYAA KTVFEALQAP ACHENMVKVG
510 520 530 540 550
GYILGEFGNL IAGDPRSSPP VQFSLLHSKF HLCSVATRAL LLSTYIKFIN
560 570 580 590 600
LFPETKATIQ GVLRAGSQLR NADVELQQRA VEYLTLSSVA STDVLATVLE
610 620 630 640 650
EMPPFPERES SILAKLKRKK GPGAASALDD SRRDTSSNDI NGGVEPTPSN
660 670 680 690 700
VSTPSPSADL LGLRAAPPPA APPAPVGGNL LVDVFSDGPT AQPSLGPTPE
710 720 730 740 750
EAFLSELEPP APESPMTLLA DPAPAADPGP EDIGPPIPEA DELLNKFVCK
760 770 780 790 800
NSGVLFENQL LQIGVKSEFR QNLGRMYLFY GNKTSVQFQS FLPTVVHPGD
810 820 830 840 850
LQTHLAVQTK RVAAQVDGGA QVQQVLNIEC LRDFLTPPLL SVRFRYGGTA
860 870 880 890 900
QSLTLKLPVT INKFFQPTEM AAQDFFQRWK QLSLPLQEAQ KIFKANHPMD
910 920 930 940 950
AEVTKAKLLG FGSALLDNVD PNPENFVGAG IIQTKALQVG CLLRLEPNAQ
960 970
AQMYRLTLRT SKEPVSRHLC ELLAQQF
Length:977
Mass (Da):107,675
Last modified:April 20, 2010 - v1
Checksum:i5704048BEC825FDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC094894 Genomic DNA. No translation available.
CH473979 Genomic DNA. Translation: EDM07441.1.
RefSeqiNP_001100981.1. NM_001107511.2.
UniGeneiRn.162416.

Genome annotation databases

EnsembliENSRNOT00000020304; ENSRNOP00000020304; ENSRNOG00000026243.
GeneIDi308578.
KEGGirno:308578.
UCSCiRGD:1306254. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC094894 Genomic DNA. No translation available.
CH473979 Genomic DNA. Translation: EDM07441.1.
RefSeqiNP_001100981.1. NM_001107511.2.
UniGeneiRn.162416.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiD3ZUY8. 1 interactor.
STRINGi10116.ENSRNOP00000020304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020304; ENSRNOP00000020304; ENSRNOG00000026243.
GeneIDi308578.
KEGGirno:308578.
UCSCiRGD:1306254. rat.

Organism-specific databases

CTDi160.
RGDi1306254. Ap2a1.

Phylogenomic databases

eggNOGiKOG1077. Eukaryota.
ENOG410XNQE. LUCA.
GeneTreeiENSGT00550000074757.
KOiK11824.
OMAiDFKTCIS.
OrthoDBiEOG091G01JZ.
TreeFamiTF300308.

Enzyme and pathway databases

ReactomeiR-RNO-177504. Retrograde neurotrophin signalling.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-416993. Trafficking of GluR2-containing AMPA receptors.
R-RNO-437239. Recycling pathway of L1.
R-RNO-5099900. WNT5A-dependent internalization of FZD4.
R-RNO-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.
R-RNO-8866427. VLDLR internalisation and degradation.
R-RNO-8964038. LDL clearance.

Gene expression databases

BgeeiENSRNOG00000026243.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR017104. AP2_complex_asu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR003164. Clathrin_a-adaptin_app_sub_C.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
PfamiView protein in Pfam
PF01602. Adaptin_N. 1 hit.
PF02296. Alpha_adaptin_C. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
SMARTiView protein in SMART
SM00809. Alpha_adaptinC2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZUY8_RAT
AccessioniPrimary (citable) accession number: D3ZUY8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 7, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.