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Protein

GDNF-inducible zinc finger protein 1

Gene

Gzf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri316 – 338C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri376 – 399C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri406 – 428C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF-inducible zinc finger protein 1
Alternative name(s):
Zinc finger protein 336
Gene namesi
Name:Gzf1
Synonyms:Zfp336
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1562321 Gzf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004096611 – 707GDNF-inducible zinc finger protein 1Add BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei612PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD3ZUU2
PeptideAtlasiD3ZUU2
PRIDEiD3ZUU2

PTM databases

iPTMnetiD3ZUU2
PhosphoSitePlusiD3ZUU2

Expressioni

Gene expression databases

BgeeiENSRNOG00000004735
GenevisibleiD3ZUU2 RN

Interactioni

Subunit structurei

Interacts with NCL.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006287

Structurei

3D structure databases

SMRiD3ZUU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 103BTBPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri316 – 338C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri376 – 399C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri406 – 428C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136554
InParanoidiD3ZUU2
KOiK22402
OMAiKYTRRLR
OrthoDBiEOG091G02KC
PhylomeDBiD3ZUU2
TreeFamiTF350965

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

D3ZUU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGTVLLES KSSPLNLLHE MHELRLLGHL CDVTVIVDYQ GVREDFMAHK
60 70 80 90 100
AVLAATSKFF KEVFLNEKRA DGTRTNVYLS EVQVVDFASF LEFVYTARVR
110 120 130 140 150
VKEDRVQQML EVAEKLKCLD LSETCLQLKK QMLESVLLEL QNFSESQEVE
160 170 180 190 200
ASSGPQVSVT PSSKASVPAG EDAHSNGLVD SSDYPIERLG NGLSPETPSK
210 220 230 240 250
KCKEKLDKKK DVAKPPFPKI RRASGRLAGK KVFVEIPKKK YTRRLREQQK
260 270 280 290 300
SAEEAAKNDK CPQDQSPDNE RVEAEPASKS EACPASVERE ESLQKVEGEK
310 320 330 340 350
EEEEGKDGEE KKKSNFQCTV CDKAFLYEKS FLKHIKYHHG VATEVVYRCD
360 370 380 390 400
TCGQTFANRC NLKSHQRHVH SSERHFPCEM CAKKFKRKKD VKRHVLQVHE
410 420 430 440 450
GGGERHRCGQ CGKGLSSKTA LRLHERTHTG DKPYGCTKCD AKFSQPSALK
460 470 480 490 500
THLRVHTGER PFVCDECGAR FTQNHMLIYH KRCHTGERPF MCETCGKSFA
510 520 530 540 550
SKEYLKHHNR IHTGSKPFKC EVCLRTFAQR NSLYQHIKVH TGERPYCCDQ
560 570 580 590 600
CGKQFTQVNA LQRHHRIHTG EKPYMCNACG RTFTDKSTLR RHTSIHDKNT
610 620 630 640 650
PWKSFLVIVD GSPKNDEGQK TEQPDEEYAS PKLSDRLLSF GENSHFNNLL
660 670 680 690 700
EVQGNVPAVQ ENSSTDTACK AVVSQDALLT TSISALGELT PQTVSMPAHL

PSLTNME
Length:707
Mass (Da):79,887
Last modified:April 20, 2010 - v1
Checksum:i2DB5E7ADA8C5E926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474026 Genomic DNA Translation: EDL95094.1
CH474026 Genomic DNA Translation: EDL95095.1
RefSeqiNP_001101258.1, NM_001107788.1
XP_006235215.1, XM_006235153.3
XP_006235216.1, XM_006235154.2
XP_008760496.1, XM_008762274.2
XP_017447260.1, XM_017591771.1
UniGeneiRn.40179

Genome annotation databases

EnsembliENSRNOT00000006287; ENSRNOP00000006287; ENSRNOG00000004735
GeneIDi311508
KEGGirno:311508
UCSCiRGD:1562321 rat

Similar proteinsi

Entry informationi

Entry nameiGZF1_RAT
AccessioniPrimary (citable) accession number: D3ZUU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: April 20, 2010
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health