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Protein

GDNF-inducible zinc finger protein 1

Gene

Gzf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri316 – 33823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 37024C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri376 – 39924C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri406 – 42823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri434 – 45623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri462 – 48423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri490 – 51223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri518 – 54023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri546 – 56823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri574 – 59623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF-inducible zinc finger protein 1
Alternative name(s):
Zinc finger protein 336
Gene namesi
Name:Gzf1
Synonyms:Zfp336
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1562321. Gzf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707GDNF-inducible zinc finger protein 1PRO_0000409661Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei612 – 6121PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD3ZUU2.

PTM databases

iPTMnetiD3ZUU2.

Expressioni

Gene expression databases

GenevisibleiD3ZUU2. RN.

Interactioni

Subunit structurei

Interacts with NCL.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006287.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 10373BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri316 – 33823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 37024C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri376 – 39924C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri406 – 42823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri434 – 45623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri462 – 48423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri490 – 51223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri518 – 54023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri546 – 56823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri574 – 59623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111259.
InParanoidiD3ZUU2.
OMAiKHISTYH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiD3ZUU2.
TreeFamiTF350965.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZUU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGTVLLES KSSPLNLLHE MHELRLLGHL CDVTVIVDYQ GVREDFMAHK
60 70 80 90 100
AVLAATSKFF KEVFLNEKRA DGTRTNVYLS EVQVVDFASF LEFVYTARVR
110 120 130 140 150
VKEDRVQQML EVAEKLKCLD LSETCLQLKK QMLESVLLEL QNFSESQEVE
160 170 180 190 200
ASSGPQVSVT PSSKASVPAG EDAHSNGLVD SSDYPIERLG NGLSPETPSK
210 220 230 240 250
KCKEKLDKKK DVAKPPFPKI RRASGRLAGK KVFVEIPKKK YTRRLREQQK
260 270 280 290 300
SAEEAAKNDK CPQDQSPDNE RVEAEPASKS EACPASVERE ESLQKVEGEK
310 320 330 340 350
EEEEGKDGEE KKKSNFQCTV CDKAFLYEKS FLKHIKYHHG VATEVVYRCD
360 370 380 390 400
TCGQTFANRC NLKSHQRHVH SSERHFPCEM CAKKFKRKKD VKRHVLQVHE
410 420 430 440 450
GGGERHRCGQ CGKGLSSKTA LRLHERTHTG DKPYGCTKCD AKFSQPSALK
460 470 480 490 500
THLRVHTGER PFVCDECGAR FTQNHMLIYH KRCHTGERPF MCETCGKSFA
510 520 530 540 550
SKEYLKHHNR IHTGSKPFKC EVCLRTFAQR NSLYQHIKVH TGERPYCCDQ
560 570 580 590 600
CGKQFTQVNA LQRHHRIHTG EKPYMCNACG RTFTDKSTLR RHTSIHDKNT
610 620 630 640 650
PWKSFLVIVD GSPKNDEGQK TEQPDEEYAS PKLSDRLLSF GENSHFNNLL
660 670 680 690 700
EVQGNVPAVQ ENSSTDTACK AVVSQDALLT TSISALGELT PQTVSMPAHL

PSLTNME
Length:707
Mass (Da):79,887
Last modified:April 20, 2010 - v1
Checksum:i2DB5E7ADA8C5E926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474026 Genomic DNA. Translation: EDL95094.1.
CH474026 Genomic DNA. Translation: EDL95095.1.
RefSeqiNP_001101258.1. NM_001107788.1.
XP_006235215.1. XM_006235153.2.
XP_006235216.1. XM_006235154.2.
XP_008760496.1. XM_008762274.1.
UniGeneiRn.40179.

Genome annotation databases

EnsembliENSRNOT00000006287; ENSRNOP00000006287; ENSRNOG00000004735.
GeneIDi311508.
KEGGirno:311508.
UCSCiRGD:1562321. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474026 Genomic DNA. Translation: EDL95094.1.
CH474026 Genomic DNA. Translation: EDL95095.1.
RefSeqiNP_001101258.1. NM_001107788.1.
XP_006235215.1. XM_006235153.2.
XP_006235216.1. XM_006235154.2.
XP_008760496.1. XM_008762274.1.
UniGeneiRn.40179.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006287.

PTM databases

iPTMnetiD3ZUU2.

Proteomic databases

PaxDbiD3ZUU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006287; ENSRNOP00000006287; ENSRNOG00000004735.
GeneIDi311508.
KEGGirno:311508.
UCSCiRGD:1562321. rat.

Organism-specific databases

CTDi64412.
RGDi1562321. Gzf1.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111259.
InParanoidiD3ZUU2.
OMAiKHISTYH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiD3ZUU2.
TreeFamiTF350965.

Miscellaneous databases

PROiD3ZUU2.

Gene expression databases

GenevisibleiD3ZUU2. RN.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-612, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGZF1_RAT
AccessioniPrimary (citable) accession number: D3ZUU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: April 20, 2010
Last modified: June 8, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.