D3ZUH9 (D3ZUH9_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Low density lipoprotein receptor-related protein 6 (Predicted) EMBL EDM01658.1

Submitted name:
Protein Lrp6 Ensembl ENSRNOP00000063261

Gene names

Name:	Lrp6 Ensembl ENSRNOP00000063261
Synonyms:	Lrp6_predicted EMBL EDM01658.1
ORF Names:	rCG_29933 EMBL EDM01658.1

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000063261

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1234 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Cellular component	Membrane
Domain	EGF-like domain SAAS SAAS000033 Repeat SAAS SAAS000033 Transmembrane Transmembrane helix SAAS SAAS000033
Molecular function	Receptor EMBL EDM01658.1
PTM	Disulfide bond SAAS SAAS000033 Lipoprotein EMBL EDM01658.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway involved in dorsal/ventral axis specification Inferred from electronic annotation. Source: Compara Wnt receptor signaling pathway involved in forebrain neuroblast division Inferred from electronic annotation. Source: Compara Wnt receptor signaling pathway involved in somitogenesis Inferred from electronic annotation. Source: Compara axis elongation involved in somitogenesis Inferred from electronic annotation. Source: Compara bone remodeling Inferred from electronic annotation. Source: Compara branching involved in mammary gland duct morphogenesis Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation Inferred from electronic annotation. Source: Compara cell migration involved in gastrulation Inferred from electronic annotation. Source: Compara cellular response to cholesterol Inferred from electronic annotation. Source: Compara cerebellum morphogenesis Inferred from electronic annotation. Source: Compara cerebral cortex cell migration Inferred from electronic annotation. Source: Compara convergent extension Inferred from electronic annotation. Source: Compara dopaminergic neuron differentiation Inferred from electronic annotation. Source: Compara embryonic camera-type eye morphogenesis Inferred from electronic annotation. Source: Compara embryonic digit morphogenesis Inferred from electronic annotation. Source: Compara embryonic forelimb morphogenesis Inferred from electronic annotation. Source: Compara embryonic hindlimb morphogenesis Inferred from electronic annotation. Source: Compara embryonic pattern specification Inferred from electronic annotation. Source: Compara embryonic retina morphogenesis in camera-type eye Inferred from electronic annotation. Source: Compara external genitalia morphogenesis Inferred from electronic annotation. Source: Compara face morphogenesis Inferred from electronic annotation. Source: Compara forebrain radial glial cell differentiation Inferred from electronic annotation. Source: Compara formation of radial glial scaffolds Inferred from electronic annotation. Source: Compara heart looping Inferred from electronic annotation. Source: Compara mammary placode formation Inferred from electronic annotation. Source: Compara midbrain development Inferred from electronic annotation. Source: Compara midbrain-hindbrain boundary development Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of fat cell differentiation Inferred from electronic annotation. Source: Compara negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of planar cell polarity pathway involved in neural tube closure Inferred from electronic annotation. Source: Compara negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of planar cell polarity pathway involved in pericardium morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of protein serine/threonine kinase activity Inferred from electronic annotation. Source: Compara negative regulation of smooth muscle cell apoptotic process Inferred from electronic annotation. Source: Compara neural crest formation Inferred from electronic annotation. Source: Compara neural tube closure Inferred from electronic annotation. Source: Compara odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara palate development Inferred from electronic annotation. Source: Compara pericardium morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of bone resorption Inferred from electronic annotation. Source: Compara positive regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of cell cycle Inferred from electronic annotation. Source: Compara positive regulation of mesenchymal cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of ossification Inferred from electronic annotation. Source: Compara positive regulation of sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara post-anal tail morphogenesis Inferred from electronic annotation. Source: Compara primitive streak formation Inferred from electronic annotation. Source: Compara receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport Inferred from electronic annotation. Source: Compara regulation of cell development Inferred from electronic annotation. Source: Compara response to folic acid Inferred from electronic annotation. Source: Compara skeletal system morphogenesis Inferred from electronic annotation. Source: Compara thalamus development Inferred from electronic annotation. Source: Compara trachea cartilage morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	caveola Inferred from electronic annotation. Source: Compara cell surface Inferred from electronic annotation. Source: Compara cytoplasmic vesicle Inferred from electronic annotation. Source: Compara early endosome Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	coreceptor activity involved in Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara kinase inhibitor activity Inferred from electronic annotation. Source: Compara low-density lipoprotein receptor activity Inferred from electronic annotation. Source: Compara toxin transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D3ZUH9 [UniParc]. Last modified April 20, 2010. Version 1. Checksum: 2C34CA7DD6BB0F2A	FASTA	1,234	139,375
	10 20 30 40 50 60 MYWTDWGEVP KIERAGMDGS SRFVIINTEI YWPNGLTLDY EERKLYWADA KLNFIHKSNL 70 80 90 100 110 120 DGTNRQAVVK GSLPHPFALT LFEDTLYWTD WNTHSILACN KYTGEGLREI HSNIFSPMDI 130 140 150 160 170 180 HAFSQQRQPN ATNPCGIDNG GCSHLCLMSP VKPFYQCACP TGVKLLESGK TCKDGATELL 190 200 210 220 230 240 LLARRTDLRR ISLDTPDFTD IVLQLEDIRH AIAIDYDPVE GYVYWTDDEV RAIRRSFIDG 250 260 270 280 290 300 SGSQFVVTAQ IAHPDGIAVD WVARNLYWTD TGTDRIEVTR LNGTMRKILI SEDLEEPRAI 310 320 330 340 350 360 VLDPMAGYMY WTDWGEIPKI ERAALDGSDR VVLVNTSLGW PNGLALDYDE GTIYWGDAKT 370 380 390 400 410 420 DKIEVMNTDG TGRRVLVEDK IPHIFGFTLL GDYVYWTDWQ RRSIERVHKR SAEREVIIDQ 430 440 450 460 470 480 LPDLMGLKAT SVHRVIGSNP CAEENGGCSH LCLYRPQGLR CACPIGFELI SDMKTCIVPE 490 500 510 520 530 540 AFLLFSRRAD IRRISLETNN NNVAIPLTGV KEASALDFDV TDNRIYWTDI SLKTISRAFM 550 560 570 580 590 600 NGSALEHVVE FGLDYPEGMA VDWLGKNLYW ADTGTNRIEV SKLDGQHRQV LVWKDLDSPR 610 620 630 640 650 660 ALALDPAEGF MYWTEWGGKP KIDRAAMDGS ERTTLVPNVG RANGLTIDYA KRRLYWTDLD 670 680 690 700 710 720 TNLIESSNML GLNREVIADD LPHPFGLTQY QDYIYWTDWS RRSIERANKT SGQNRTIIQG 730 740 750 760 770 780 HLDYVMDILV FHSSRQAGWN ECASSNGHCS HLCLAVPVGG FVCGCPAHYS LNADNRTCSA 790 800 810 820 830 840 PTTFLLFSQK SAINRMVIDE QQSPDIILPI HSLRNVRAID YDPLDKQLYW IDSRQNMIRK 850 860 870 880 890 900 AQEDGGQGFT VVVSSVPNQN LEIQPYDLSI DIYSRYIYWT CEATNVIDVT RLDGRSVGVV 910 920 930 940 950 960 LKGEQDRPRA IVVNPEKGYM YFTNLQERSP KIERAALDGT EREVLFFSGL SKPVALALDS 970 980 990 1000 1010 1020 KLSRLFWADS DLRRIESSDL SGANRIVLED SNILQPVGLT VFENWLYWID KQQQMIEKID 1030 1040 1050 1060 1070 1080 MTGREGRTKV QARIAQLSDI HAVKELNLQE YRQHPCAQDN GGCSHICLVK GDGTTRCSCP 1090 1100 1110 1120 1130 1140 MHLVLLQDEL SCGEPPTCSP QQFTCFTGDI DCIPVAWRCD GFTECEDHSD ELNCPVCSES 1150 1160 1170 1180 1190 1200 QFQCASGQCI DGALRCNGDA NCQDKSDEKN CEVLCLIDQF RCANGQCVGK HKKCDHNVDC 1210 1220 1230 SDRSDELDCY FEPTTILQAV QLPALCTAHY TLQH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000063261.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM01658.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM01658.1.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000063261.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06033859 Genomic DNA. No translation available. AABR06033860 Genomic DNA. No translation available. CH473964 Genomic DNA. Translation: EDM01658.1.
IPI	IPI00948746.
RefSeq	NP_001101362.1. NM_001107892.1.
UniGene	Rn.229041.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000066575; ENSRNOP00000063261; ENSRNOG00000006338.
GeneID	312781.
KEGG	rno:312781.
Organism-specific databases
CTD	4040.
RGD	1304749. Lrp6.
Phylogenomic databases
GeneTree	ENSGT00690000101695.
KO	K03068.
Family and domain databases
Gene3D	2.120.10.30. 4 hits. 4.10.400.10. 3 hits.
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR000742. EG-like_dom. IPR023415. LDLR_class-A_CS. IPR000033. LDLR_classB_rpt. IPR002172. LDrepeatLR_classA_rpt. [Graphical view]
Pfam	PF00057. Ldl_recept_a. 3 hits. PF00058. Ldl_recept_b. 12 hits. [Graphical view]
SMART	SM00181. EGF. 4 hits. SM00192. LDLa. 3 hits. SM00135. LY. 17 hits. [Graphical view]
SUPFAM	SSF57424. LDL_rcpt_classA_cys-rich. 3 hits.
PROSITE	PS01209. LDLRA_1. 3 hits. PS50068. LDLRA_2. 3 hits. PS51120. LDLRB. 18 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	665251.

Entry information

Entry name

D3ZUH9_RAT

Accession

Primary (citable) accession number: D3ZUH9

Entry history

Integrated into UniProtKB/TrEMBL:	April 20, 2010
Last sequence update:	April 20, 2010
Last modified:	April 3, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)