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D3ZU96

- UBP42_RAT

UniProt

D3ZU96 - UBP42_RAT

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Protein
Ubiquitin carboxyl-terminal hydrolase 42
Gene
Usp42
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Deubiquitinating enzyme which may play an important role during spermatogenesis By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 1191Nucleophile By similarity
Active sitei370 – 3701Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: Ensembl

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. protein deubiquitination Source: UniProtKB
  3. spermatogenesis Source: UniProtKB-KW
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Differentiation, Spermatogenesis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
Gene namesi
Name:Usp42
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 12

Organism-specific databases

RGDi1305231. Usp42.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13251325Ubiquitin carboxyl-terminal hydrolase 42
PRO_0000404200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei858 – 8581Phosphoserine By similarity
Modified residuei1235 – 12351Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 411302USP
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi787 – 7904Poly-Val
Compositional biasi1185 – 125571Lys-rich
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

GeneTreeiENSGT00750000117288.
KOiK11855.
OMAiGKLMPAP.
OrthoDBiEOG72VH5K.
PhylomeDBiD3ZU96.
TreeFamiTF315281.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZU96-1 [UniParc]FASTAAdd to Basket

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MTIVDKTEPS DPSTCQNQPG SSEAVSPEDM DTGSASWGAV SSISDVSNHT     50
LSLGPVPGAV VYNNSSVPEK SKPSPPKDQV LGDGIAPPQK VLFPSEKICL 100
KWQQSHRVGA GLQNLGNTCF ANAALQCLTY TPPLANYMLS HEHSKTCHAE 150
GFCMMCTMQT HITQALSNPG DVIKPMFVIN EMRRIARHFR FGNQEDAHEF 200
LQYTVDAMQK ACLNGSNKLD RHTQATTLVC QIFGGYLRSR VKCLNCKGVS 250
DTFDPYLDIT LEIKAAQSVT KALEQFVKPE QLDGENSYKC SKCKKMVPAS 300
KRFTIHRSSN VLTISLKRFA NFTGGKIAKD VKYPEYLDIR PYMSQPNGEP 350
IIYVLYAVLV HTGFNCHAGH YFCYIKASNG LWYQMNDSIV STSDIRSVLN 400
QQAYVLFYIR SHDVKNGGET THPAHSPGQS SPRPGISQRV VNSKQAAPGF 450
IGPQLPPHVM KNTPHLNGTT PVKDTPSSSV SSPNGNTSVN RASPATASTS 500
VQNWSVNRPS VIPEHPKKQK ITISIHNKLP VRQGQAQLNN NLHGPCLEAP 550
SKAAPSSTIT NPSAIQSTSN APTTSVSPSE SCPKPMVNGK AKVGSSVLVP 600
YGAESSEESD EESKGLAKEN GVDMMTSTQS SRPETADEDG EASPHELQES 650
VMLNGANSAD SDSRESSLAF DSASCQVQPD LHTENLFNKL NGLPGKVTPA 700
PLQSVPEDKI LETFKLTNQA KGPAVEESWT TTGGSSPRAS VSQPEPITDE 750
TSPLEIPEAV TNGSMKTPST TSPLEPTISC TKEDSSVVVV SAEPMEVLPS 800
VPALCNSTGT TLGDAPVPES CDPGDLTANP SQPSQAVKGD PAENSENSTL 850
AEVVERLSPA PSVLTGDGCE QKLFLYLSTE GSEEAEDSSR SSAVSADTVP 900
PQPDRTTSSC AGAAEQAAGD RGDGGSVGPK AQEPSPAKEK MNSLRKVDRG 950
HYRSRRDRSS SGEHVRDSRA RPEDHHHKKR RCYSRERPKQ ERHPANTYCN 1000
GGQHLGHGDR ASPERRSLSR YSHHHSRVRS GLEQDWSRYH HSENEPAWAR 1050
ERFYPDKMRW DKCRYYHDRY TTTLYTAREA AREWRPLHGR EHERLVQSGR 1100
PHKDSYWGRK GWDLQSRGKE RPHFHSPREA PGLAVPLERH LQEKAALSVQ 1150
DSSHSLPERF HEHESVKLRK RRYETLDNND DHPEKKVHKS LEKDALEEPR 1200
AKKHKKSKKK KKSKDKHRAR DSRHQQESDF SGAYSDADLH RHRKKKKKKK 1250
RHSRKSEDFI KDVEMHLPKL SSYEAVGHFR RTEGTFLLAD GLPVEDSGPF 1300
REKTKHLRME SRPDRCHLSE YGQGN 1325
Length:1,325
Mass (Da):146,357
Last modified:April 20, 2010 - v1
Checksum:iEAC3721C860F59EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH474012 Genomic DNA. Translation: EDL89655.1.
RefSeqiNP_001099379.1. NM_001105909.1.
XP_006248926.1. XM_006248864.1.
UniGeneiRn.25011.

Genome annotation databases

EnsembliENSRNOT00000001404; ENSRNOP00000001404; ENSRNOG00000001059.
GeneIDi288482.
KEGGirno:288482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH474012 Genomic DNA. Translation: EDL89655.1 .
RefSeqi NP_001099379.1. NM_001105909.1.
XP_006248926.1. XM_006248864.1.
UniGenei Rn.25011.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000001404 ; ENSRNOP00000001404 ; ENSRNOG00000001059 .
GeneIDi 288482.
KEGGi rno:288482.

Organism-specific databases

CTDi 84132.
RGDi 1305231. Usp42.

Phylogenomic databases

GeneTreei ENSGT00750000117288.
KOi K11855.
OMAi GKLMPAP.
OrthoDBi EOG72VH5K.
PhylomeDBi D3ZU96.
TreeFami TF315281.

Miscellaneous databases

NextBioi 628152.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUBP42_RAT
AccessioniPrimary (citable) accession number: D3ZU96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: April 20, 2010
Last modified: April 16, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi