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D3ZU96

- UBP42_RAT

UniProt

D3ZU96 - UBP42_RAT

Protein

Ubiquitin carboxyl-terminal hydrolase 42

Gene

Usp42

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme which may play an important role during spermatogenesis.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei119 – 1191NucleophilePROSITE-ProRule annotation
    Active sitei370 – 3701Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: Ensembl

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. protein deubiquitination Source: UniProtKB
    3. spermatogenesis Source: UniProtKB-KW
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Differentiation, Spermatogenesis, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 42
    Ubiquitin thioesterase 42
    Ubiquitin-specific-processing protease 42
    Gene namesi
    Name:Usp42
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 12

    Organism-specific databases

    RGDi1305231. Usp42.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13251325Ubiquitin carboxyl-terminal hydrolase 42PRO_0000404200Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei858 – 8581PhosphoserineBy similarity
    Modified residuei1235 – 12351PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini110 – 411302USPAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi787 – 7904Poly-Val
    Compositional biasi1185 – 125571Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    GeneTreeiENSGT00750000117288.
    KOiK11855.
    OMAiGKLMPAP.
    OrthoDBiEOG72VH5K.
    PhylomeDBiD3ZU96.
    TreeFamiTF315281.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3ZU96-1 [UniParc]FASTAAdd to Basket

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    MTIVDKTEPS DPSTCQNQPG SSEAVSPEDM DTGSASWGAV SSISDVSNHT     50
    LSLGPVPGAV VYNNSSVPEK SKPSPPKDQV LGDGIAPPQK VLFPSEKICL 100
    KWQQSHRVGA GLQNLGNTCF ANAALQCLTY TPPLANYMLS HEHSKTCHAE 150
    GFCMMCTMQT HITQALSNPG DVIKPMFVIN EMRRIARHFR FGNQEDAHEF 200
    LQYTVDAMQK ACLNGSNKLD RHTQATTLVC QIFGGYLRSR VKCLNCKGVS 250
    DTFDPYLDIT LEIKAAQSVT KALEQFVKPE QLDGENSYKC SKCKKMVPAS 300
    KRFTIHRSSN VLTISLKRFA NFTGGKIAKD VKYPEYLDIR PYMSQPNGEP 350
    IIYVLYAVLV HTGFNCHAGH YFCYIKASNG LWYQMNDSIV STSDIRSVLN 400
    QQAYVLFYIR SHDVKNGGET THPAHSPGQS SPRPGISQRV VNSKQAAPGF 450
    IGPQLPPHVM KNTPHLNGTT PVKDTPSSSV SSPNGNTSVN RASPATASTS 500
    VQNWSVNRPS VIPEHPKKQK ITISIHNKLP VRQGQAQLNN NLHGPCLEAP 550
    SKAAPSSTIT NPSAIQSTSN APTTSVSPSE SCPKPMVNGK AKVGSSVLVP 600
    YGAESSEESD EESKGLAKEN GVDMMTSTQS SRPETADEDG EASPHELQES 650
    VMLNGANSAD SDSRESSLAF DSASCQVQPD LHTENLFNKL NGLPGKVTPA 700
    PLQSVPEDKI LETFKLTNQA KGPAVEESWT TTGGSSPRAS VSQPEPITDE 750
    TSPLEIPEAV TNGSMKTPST TSPLEPTISC TKEDSSVVVV SAEPMEVLPS 800
    VPALCNSTGT TLGDAPVPES CDPGDLTANP SQPSQAVKGD PAENSENSTL 850
    AEVVERLSPA PSVLTGDGCE QKLFLYLSTE GSEEAEDSSR SSAVSADTVP 900
    PQPDRTTSSC AGAAEQAAGD RGDGGSVGPK AQEPSPAKEK MNSLRKVDRG 950
    HYRSRRDRSS SGEHVRDSRA RPEDHHHKKR RCYSRERPKQ ERHPANTYCN 1000
    GGQHLGHGDR ASPERRSLSR YSHHHSRVRS GLEQDWSRYH HSENEPAWAR 1050
    ERFYPDKMRW DKCRYYHDRY TTTLYTAREA AREWRPLHGR EHERLVQSGR 1100
    PHKDSYWGRK GWDLQSRGKE RPHFHSPREA PGLAVPLERH LQEKAALSVQ 1150
    DSSHSLPERF HEHESVKLRK RRYETLDNND DHPEKKVHKS LEKDALEEPR 1200
    AKKHKKSKKK KKSKDKHRAR DSRHQQESDF SGAYSDADLH RHRKKKKKKK 1250
    RHSRKSEDFI KDVEMHLPKL SSYEAVGHFR RTEGTFLLAD GLPVEDSGPF 1300
    REKTKHLRME SRPDRCHLSE YGQGN 1325
    Length:1,325
    Mass (Da):146,357
    Last modified:April 20, 2010 - v1
    Checksum:iEAC3721C860F59EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474012 Genomic DNA. Translation: EDL89655.1.
    RefSeqiNP_001099379.1. NM_001105909.1.
    XP_006248926.1. XM_006248864.1.
    UniGeneiRn.25011.

    Genome annotation databases

    EnsembliENSRNOT00000001404; ENSRNOP00000001404; ENSRNOG00000001059.
    GeneIDi288482.
    KEGGirno:288482.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474012 Genomic DNA. Translation: EDL89655.1 .
    RefSeqi NP_001099379.1. NM_001105909.1.
    XP_006248926.1. XM_006248864.1.
    UniGenei Rn.25011.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000001404 ; ENSRNOP00000001404 ; ENSRNOG00000001059 .
    GeneIDi 288482.
    KEGGi rno:288482.

    Organism-specific databases

    CTDi 84132.
    RGDi 1305231. Usp42.

    Phylogenomic databases

    GeneTreei ENSGT00750000117288.
    KOi K11855.
    OMAi GKLMPAP.
    OrthoDBi EOG72VH5K.
    PhylomeDBi D3ZU96.
    TreeFami TF315281.

    Miscellaneous databases

    NextBioi 628152.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiUBP42_RAT
    AccessioniPrimary (citable) accession number: D3ZU96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3