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D3ZU96

- UBP42_RAT

UniProt

D3ZU96 - UBP42_RAT

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Protein

Ubiquitin carboxyl-terminal hydrolase 42

Gene

Usp42

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Deubiquitinating enzyme which may play an important role during spermatogenesis.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 1191NucleophilePROSITE-ProRule annotation
Active sitei370 – 3701Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: Ensembl

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. protein deubiquitination Source: UniProtKB
  3. spermatogenesis Source: UniProtKB-KW
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Differentiation, Spermatogenesis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
Gene namesi
Name:Usp42
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 12

Organism-specific databases

RGDi1305231. Usp42.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13251325Ubiquitin carboxyl-terminal hydrolase 42PRO_0000404200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei858 – 8581PhosphoserineBy similarity
Modified residuei1235 – 12351PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 411302USPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi787 – 7904Poly-Val
Compositional biasi1185 – 125571Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119279.
InParanoidiD3ZU96.
KOiK11855.
OMAiGKLMPAP.
OrthoDBiEOG72VH5K.
PhylomeDBiD3ZU96.
TreeFamiTF315281.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZU96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIVDKTEPS DPSTCQNQPG SSEAVSPEDM DTGSASWGAV SSISDVSNHT
60 70 80 90 100
LSLGPVPGAV VYNNSSVPEK SKPSPPKDQV LGDGIAPPQK VLFPSEKICL
110 120 130 140 150
KWQQSHRVGA GLQNLGNTCF ANAALQCLTY TPPLANYMLS HEHSKTCHAE
160 170 180 190 200
GFCMMCTMQT HITQALSNPG DVIKPMFVIN EMRRIARHFR FGNQEDAHEF
210 220 230 240 250
LQYTVDAMQK ACLNGSNKLD RHTQATTLVC QIFGGYLRSR VKCLNCKGVS
260 270 280 290 300
DTFDPYLDIT LEIKAAQSVT KALEQFVKPE QLDGENSYKC SKCKKMVPAS
310 320 330 340 350
KRFTIHRSSN VLTISLKRFA NFTGGKIAKD VKYPEYLDIR PYMSQPNGEP
360 370 380 390 400
IIYVLYAVLV HTGFNCHAGH YFCYIKASNG LWYQMNDSIV STSDIRSVLN
410 420 430 440 450
QQAYVLFYIR SHDVKNGGET THPAHSPGQS SPRPGISQRV VNSKQAAPGF
460 470 480 490 500
IGPQLPPHVM KNTPHLNGTT PVKDTPSSSV SSPNGNTSVN RASPATASTS
510 520 530 540 550
VQNWSVNRPS VIPEHPKKQK ITISIHNKLP VRQGQAQLNN NLHGPCLEAP
560 570 580 590 600
SKAAPSSTIT NPSAIQSTSN APTTSVSPSE SCPKPMVNGK AKVGSSVLVP
610 620 630 640 650
YGAESSEESD EESKGLAKEN GVDMMTSTQS SRPETADEDG EASPHELQES
660 670 680 690 700
VMLNGANSAD SDSRESSLAF DSASCQVQPD LHTENLFNKL NGLPGKVTPA
710 720 730 740 750
PLQSVPEDKI LETFKLTNQA KGPAVEESWT TTGGSSPRAS VSQPEPITDE
760 770 780 790 800
TSPLEIPEAV TNGSMKTPST TSPLEPTISC TKEDSSVVVV SAEPMEVLPS
810 820 830 840 850
VPALCNSTGT TLGDAPVPES CDPGDLTANP SQPSQAVKGD PAENSENSTL
860 870 880 890 900
AEVVERLSPA PSVLTGDGCE QKLFLYLSTE GSEEAEDSSR SSAVSADTVP
910 920 930 940 950
PQPDRTTSSC AGAAEQAAGD RGDGGSVGPK AQEPSPAKEK MNSLRKVDRG
960 970 980 990 1000
HYRSRRDRSS SGEHVRDSRA RPEDHHHKKR RCYSRERPKQ ERHPANTYCN
1010 1020 1030 1040 1050
GGQHLGHGDR ASPERRSLSR YSHHHSRVRS GLEQDWSRYH HSENEPAWAR
1060 1070 1080 1090 1100
ERFYPDKMRW DKCRYYHDRY TTTLYTAREA AREWRPLHGR EHERLVQSGR
1110 1120 1130 1140 1150
PHKDSYWGRK GWDLQSRGKE RPHFHSPREA PGLAVPLERH LQEKAALSVQ
1160 1170 1180 1190 1200
DSSHSLPERF HEHESVKLRK RRYETLDNND DHPEKKVHKS LEKDALEEPR
1210 1220 1230 1240 1250
AKKHKKSKKK KKSKDKHRAR DSRHQQESDF SGAYSDADLH RHRKKKKKKK
1260 1270 1280 1290 1300
RHSRKSEDFI KDVEMHLPKL SSYEAVGHFR RTEGTFLLAD GLPVEDSGPF
1310 1320
REKTKHLRME SRPDRCHLSE YGQGN
Length:1,325
Mass (Da):146,357
Last modified:April 20, 2010 - v1
Checksum:iEAC3721C860F59EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH474012 Genomic DNA. Translation: EDL89655.1.
RefSeqiNP_001099379.1. NM_001105909.1.
UniGeneiRn.25011.

Genome annotation databases

EnsembliENSRNOT00000001404; ENSRNOP00000001404; ENSRNOG00000001059.
GeneIDi288482.
KEGGirno:288482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH474012 Genomic DNA. Translation: EDL89655.1 .
RefSeqi NP_001099379.1. NM_001105909.1.
UniGenei Rn.25011.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000001404 ; ENSRNOP00000001404 ; ENSRNOG00000001059 .
GeneIDi 288482.
KEGGi rno:288482.

Organism-specific databases

CTDi 84132.
RGDi 1305231. Usp42.

Phylogenomic databases

GeneTreei ENSGT00760000119279.
InParanoidi D3ZU96.
KOi K11855.
OMAi GKLMPAP.
OrthoDBi EOG72VH5K.
PhylomeDBi D3ZU96.
TreeFami TF315281.

Miscellaneous databases

NextBioi 628152.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUBP42_RAT
AccessioniPrimary (citable) accession number: D3ZU96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3