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D3ZU96 (UBP42_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 42

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
Gene names
Name:Usp42
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Deubiquitinating enzyme which may play an important role during spermatogenesis By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13251325Ubiquitin carboxyl-terminal hydrolase 42
PRO_0000404200

Regions

Domain110 – 411302USP
Compositional bias787 – 7904Poly-Val
Compositional bias1185 – 125571Lys-rich

Sites

Active site1191Nucleophile By similarity
Active site3701Proton acceptor By similarity

Amino acid modifications

Modified residue8581Phosphoserine By similarity
Modified residue12351Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
D3ZU96 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: EAC3721C860F59EB

FASTA1,325146,357
        10         20         30         40         50         60 
MTIVDKTEPS DPSTCQNQPG SSEAVSPEDM DTGSASWGAV SSISDVSNHT LSLGPVPGAV 

        70         80         90        100        110        120 
VYNNSSVPEK SKPSPPKDQV LGDGIAPPQK VLFPSEKICL KWQQSHRVGA GLQNLGNTCF 

       130        140        150        160        170        180 
ANAALQCLTY TPPLANYMLS HEHSKTCHAE GFCMMCTMQT HITQALSNPG DVIKPMFVIN 

       190        200        210        220        230        240 
EMRRIARHFR FGNQEDAHEF LQYTVDAMQK ACLNGSNKLD RHTQATTLVC QIFGGYLRSR 

       250        260        270        280        290        300 
VKCLNCKGVS DTFDPYLDIT LEIKAAQSVT KALEQFVKPE QLDGENSYKC SKCKKMVPAS 

       310        320        330        340        350        360 
KRFTIHRSSN VLTISLKRFA NFTGGKIAKD VKYPEYLDIR PYMSQPNGEP IIYVLYAVLV 

       370        380        390        400        410        420 
HTGFNCHAGH YFCYIKASNG LWYQMNDSIV STSDIRSVLN QQAYVLFYIR SHDVKNGGET 

       430        440        450        460        470        480 
THPAHSPGQS SPRPGISQRV VNSKQAAPGF IGPQLPPHVM KNTPHLNGTT PVKDTPSSSV 

       490        500        510        520        530        540 
SSPNGNTSVN RASPATASTS VQNWSVNRPS VIPEHPKKQK ITISIHNKLP VRQGQAQLNN 

       550        560        570        580        590        600 
NLHGPCLEAP SKAAPSSTIT NPSAIQSTSN APTTSVSPSE SCPKPMVNGK AKVGSSVLVP 

       610        620        630        640        650        660 
YGAESSEESD EESKGLAKEN GVDMMTSTQS SRPETADEDG EASPHELQES VMLNGANSAD 

       670        680        690        700        710        720 
SDSRESSLAF DSASCQVQPD LHTENLFNKL NGLPGKVTPA PLQSVPEDKI LETFKLTNQA 

       730        740        750        760        770        780 
KGPAVEESWT TTGGSSPRAS VSQPEPITDE TSPLEIPEAV TNGSMKTPST TSPLEPTISC 

       790        800        810        820        830        840 
TKEDSSVVVV SAEPMEVLPS VPALCNSTGT TLGDAPVPES CDPGDLTANP SQPSQAVKGD 

       850        860        870        880        890        900 
PAENSENSTL AEVVERLSPA PSVLTGDGCE QKLFLYLSTE GSEEAEDSSR SSAVSADTVP 

       910        920        930        940        950        960 
PQPDRTTSSC AGAAEQAAGD RGDGGSVGPK AQEPSPAKEK MNSLRKVDRG HYRSRRDRSS 

       970        980        990       1000       1010       1020 
SGEHVRDSRA RPEDHHHKKR RCYSRERPKQ ERHPANTYCN GGQHLGHGDR ASPERRSLSR 

      1030       1040       1050       1060       1070       1080 
YSHHHSRVRS GLEQDWSRYH HSENEPAWAR ERFYPDKMRW DKCRYYHDRY TTTLYTAREA 

      1090       1100       1110       1120       1130       1140 
AREWRPLHGR EHERLVQSGR PHKDSYWGRK GWDLQSRGKE RPHFHSPREA PGLAVPLERH 

      1150       1160       1170       1180       1190       1200 
LQEKAALSVQ DSSHSLPERF HEHESVKLRK RRYETLDNND DHPEKKVHKS LEKDALEEPR 

      1210       1220       1230       1240       1250       1260 
AKKHKKSKKK KKSKDKHRAR DSRHQQESDF SGAYSDADLH RHRKKKKKKK RHSRKSEDFI 

      1270       1280       1290       1300       1310       1320 
KDVEMHLPKL SSYEAVGHFR RTEGTFLLAD GLPVEDSGPF REKTKHLRME SRPDRCHLSE 


YGQGN 

« Hide

References

[1]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH474012 Genomic DNA. Translation: EDL89655.1.
RefSeqNP_001099379.1. NM_001105909.1.
XP_006248926.1. XM_006248864.1.
UniGeneRn.25011.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000001404; ENSRNOP00000001404; ENSRNOG00000001059.
GeneID288482.
KEGGrno:288482.

Organism-specific databases

CTD84132.
RGD1305231. Usp42.

Phylogenomic databases

GeneTreeENSGT00750000117288.
KOK11855.
OMAGKLMPAP.
OrthoDBEOG72VH5K.
PhylomeDBD3ZU96.
TreeFamTF315281.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio628152.

Entry information

Entry nameUBP42_RAT
AccessionPrimary (citable) accession number: D3ZU96
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: April 20, 2010
Last modified: April 16, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries