ID   D3ZU21_RAT              Unreviewed;       757 AA.
AC   D3ZU21;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=Progesterone immunomodulatory binding factor 1 {ECO:0000313|Ensembl:ENSRNOP00000037643.4};
GN   Name=Pibf1 {ECO:0000313|Ensembl:ENSRNOP00000037643.4,
GN   ECO:0000313|RGD:1305077};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000037643.4, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000037643.4, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000037643.4,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0007829|PubMed:16641100}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA   Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.;
RT   "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT   regulation of aquaporin-2 phosphorylation at two sites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000037643.4}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000037643.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; NP_001292348.1; NM_001305419.1.
DR   RefSeq; XP_006252467.1; XM_006252405.3.
DR   RefSeq; XP_006252468.1; XM_006252406.3.
DR   RefSeq; XP_224451.3; XM_224451.8.
DR   AlphaFoldDB; D3ZU21; -.
DR   SMR; D3ZU21; -.
DR   STRING; 10116.ENSRNOP00000037643; -.
DR   iPTMnet; D3ZU21; -.
DR   PhosphoSitePlus; D3ZU21; -.
DR   PaxDb; 10116-ENSRNOP00000037643; -.
DR   PeptideAtlas; D3ZU21; -.
DR   Ensembl; ENSRNOT00000036350.8; ENSRNOP00000037643.4; ENSRNOG00000009208.9.
DR   GeneID; 306104; -.
DR   KEGG; rno:306104; -.
DR   UCSC; RGD:1305077; rat.
DR   AGR; RGD:1305077; -.
DR   CTD; 10464; -.
DR   RGD; 1305077; Pibf1.
DR   eggNOG; ENOG502QRKC; Eukaryota.
DR   GeneTree; ENSGT00390000015293; -.
DR   HOGENOM; CLU_014616_0_0_1; -.
DR   InParanoid; D3ZU21; -.
DR   OMA; KCERDTF; -.
DR   OrthoDB; 5395306at2759; -.
DR   PhylomeDB; D3ZU21; -.
DR   TreeFam; TF329068; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000009208; Expressed in ovary and 19 other cell types or tissues.
DR   GO; GO:0034451; C:centriolar satellite; ISO:RGD.
DR   GO; GO:0005813; C:centrosome; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0005136; F:interleukin-4 receptor binding; ISO:RGD.
DR   GO; GO:0060271; P:cilium assembly; ISO:RGD.
DR   GO; GO:0007080; P:mitotic metaphase chromosome alignment; ISO:RGD.
DR   GO; GO:0090307; P:mitotic spindle assembly; ISO:RGD.
DR   GO; GO:0032695; P:negative regulation of interleukin-12 production; ISO:RGD.
DR   GO; GO:0032815; P:negative regulation of natural killer cell activation; ISO:RGD.
DR   GO; GO:0031393; P:negative regulation of prostaglandin biosynthetic process; ISO:RGD.
DR   GO; GO:0042532; P:negative regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
DR   GO; GO:1905515; P:non-motile cilium assembly; ISO:RGD.
DR   GO; GO:0032733; P:positive regulation of interleukin-10 production; ISO:RGD.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
DR   GO; GO:0071539; P:protein localization to centrosome; ISO:RGD.
DR   InterPro; IPR026205; PIBF1.
DR   PANTHER; PTHR18950; PROGESTERONE-INDUCED BLOCKING FACTOR 1; 1.
DR   PANTHER; PTHR18950:SF1; PROGESTERONE-INDUCED-BLOCKING FACTOR 1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:D3ZU21};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   COILED          78..162
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          191..445
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          474..550
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          584..667
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   757 AA;  89793 MW;  06F1A165903CB7D2 CRC64;
     MSRKIAKESK KVNISSSLES EDISLETTIH TDDVSSSEER EGKVKITRQL IERKEILHNI
     QLLKIELSQK NMMIDNLKMD YLTKVEELEE KLNDALHQKQ LLTLRLDNQL TIQQKDAKKY
     QELMKQEMET ILLRQKQLEE TNHQLREKAG DVRRNLRDLE LTEEQYEKLK SFPEDQLSIP
     EFVSIRFYEL VNPLRKEIHE LQVKKNELSE ELSTNKGQLK QLTETYEEAR RNHSELLTRC
     QRLALELADT KQLVQQGDYR QENYDKVKSE RDALEQEVLE VRRKHEVLET SHIAQAKERN
     ELSKEVSTLQ QTVTLLQKDK EYLNRQNMEL SVRCAHEEDR LERLQVQLEE TKRAREEMYE
     KYVTSRDHYK TEYENKLHDE LEQIKLKTNL EIDQLRSASR EMYERENRNL REARDNALAE
     KNRAVTAEKD ALEKHEQLLD RYRELQLSTE SKVSEFLHQS KLKSFESERV QLLQEETARN
     LTQCQLECEK YQKKLEVLTK EFYSLQASSE KRITELEAQN SEHQARLDIY EKLEKELDEI
     IMQTAEIENE DEAERILYSY GYGANVPTTA KRRLKQSVHL ARRVLQLEKQ NSSILKDLDH
     QKEEVRQLSQ ELDRANSLLN QSQQPYRYLI ESVRQRDSKI DSLMKCTAQL EKDVSNLNKE
     KSALLQTKNQ MALDLEQLLN HREEFAAMKQ IIINMCSKHS ENNLLLTKVE SKSVTENQAS
     RPLTMPREHE ENVFIPKPTL FTKKEAQEWP KNQKMKA
//