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D3ZU00

- D3ZU00_RAT

UniProt

D3ZU00 - D3ZU00_RAT

Protein
Submitted name:

Prospero-related homeobox 1 (Predicted)

Gene

Prox1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    2. sequence-specific DNA binding Source: Ensembl
    3. transcription corepressor activity Source: Ensembl
    4. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. aorta smooth muscle tissue morphogenesis Source: Ensembl
    2. atrial cardiac muscle tissue morphogenesis Source: Ensembl
    3. brain development Source: RGD
    4. cell fate determination Source: Ensembl
    5. cerebellar granule cell differentiation Source: Ensembl
    6. dentate gyrus development Source: Ensembl
    7. embryonic retina morphogenesis in camera-type eye Source: Ensembl
    8. endocardium formation Source: Ensembl
    9. hepatocyte cell migration Source: Ensembl
    10. hepatocyte differentiation Source: Ensembl
    11. hepatocyte proliferation Source: Ensembl
    12. inner ear development Source: Ensembl
    13. kidney development Source: Ensembl
    14. lens fiber cell morphogenesis Source: Ensembl
    15. liver development Source: RGD
    16. lung development Source: Ensembl
    17. lymphangiogenesis Source: Ensembl
    18. negative regulation of bile acid biosynthetic process Source: Ensembl
    19. negative regulation of cell proliferation Source: Ensembl
    20. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    21. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    22. negative regulation of viral genome replication Source: Ensembl
    23. neuronal stem cell maintenance Source: Ensembl
    24. optic placode formation involved in camera-type eye formation Source: Ensembl
    25. pancreas development Source: Ensembl
    26. positive regulation of cell cycle checkpoint Source: Ensembl
    27. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    28. positive regulation of endothelial cell migration Source: Ensembl
    29. positive regulation of endothelial cell proliferation Source: Ensembl
    30. positive regulation of forebrain neuron differentiation Source: Ensembl
    31. positive regulation of heart growth Source: Ensembl
    32. positive regulation of neural precursor cell proliferation Source: Ensembl
    33. positive regulation of sarcomere organization Source: Ensembl
    34. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    35. regulation of transcription involved in lymphatic endothelial cell fate commitment Source: Ensembl
    36. response to nutrient levels Source: RGD
    37. skeletal muscle thin filament assembly Source: Ensembl
    38. venous blood vessel morphogenesis Source: Ensembl
    39. ventricular cardiac muscle tissue morphogenesis Source: Ensembl
    40. ventricular cardiac myofibril assembly Source: Ensembl
    41. ventricular septum morphogenesis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Prospero-related homeobox 1 (Predicted)Imported
    Submitted name:
    Protein Prox1Imported
    Gene namesi
    Name:Prox1Imported
    Synonyms:Prox1_predictedImported
    ORF Names:rCG_20423Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi1306890. Prox1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: RGD

    Family & Domainsi

    Keywords - Domaini

    HomeoboxImported

    Phylogenomic databases

    GeneTreeiENSGT00530000063507.
    OMAiQECLSPF.
    OrthoDBiEOG7MSMNK.
    TreeFamiTF316638.

    Family and domain databases

    InterProiIPR007738. Prox1.
    [Graphical view]
    PANTHERiPTHR12198. PTHR12198. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D3ZU00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS    50
    EQDVEYSVVQ HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN 100
    MNKNGGTEPS FQASGLSSTG SEVHQEDICS NSSRDSPPEC LSPFGRPTMS 150
    QFDVDRLCDE HLRAKRARVE NIIRGMSHSP SVALRGNENE REMAPQSVSP 200
    RESYRENKRK QKLPQQQQQS FQQLVSARKE QKREERRQLK QQLEDMQKQL 250
    RQLQEKFYQV YDSTDSENDE DGDLSEDSMR SEILDARAQD SVGRSDNEMC 300
    ELDPGQFIDR ARALIREQEM AENKPKREGS NKERDHGPNS LQPEGKHLAE 350
    TLKQELNTAM SQVVDTVVKV FSAKPSRQVP QVFPPLQIPQ ARFAVNGENH 400
    NFHTANQRLQ CFGDVIIPNP LDTFGNVQMP SSTDQTEALP LVVRKNSSEQ 450
    SASGPATGGH HQPLHQSPLS ATAGFTTPSF RHPFPLPLMA YPFQSPLGAP 500
    SGSFSGKDRA SPESLDLTRD TTSLRTKMSS HHLSHHPCSP AHPPSTAEGL 550
    SLSLIKSECG DLQDMSDISP YSGSAMKGYH PIT 583
    Length:583
    Mass (Da):64,845
    Last modified:April 20, 2010 - v1
    Checksum:iBB926DE9CEECA908
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06076839 Genomic DNA. No translation available.
    AABR06076840 Genomic DNA. No translation available.
    AABR06076841 Genomic DNA. No translation available.
    AABR06076842 Genomic DNA. No translation available.
    AABR06076843 Genomic DNA. No translation available.
    AABR06076844 Genomic DNA. No translation available.
    CH473985 Genomic DNA. Translation: EDL94973.1.
    RefSeqiNP_001100671.1. NM_001107201.1.
    UniGeneiRn.26557.

    Genome annotation databases

    EnsembliENSRNOT00000004905; ENSRNOP00000004905; ENSRNOG00000003694.
    GeneIDi305066.
    KEGGirno:305066.
    UCSCiRGD:1306890. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06076839 Genomic DNA. No translation available.
    AABR06076840 Genomic DNA. No translation available.
    AABR06076841 Genomic DNA. No translation available.
    AABR06076842 Genomic DNA. No translation available.
    AABR06076843 Genomic DNA. No translation available.
    AABR06076844 Genomic DNA. No translation available.
    CH473985 Genomic DNA. Translation: EDL94973.1 .
    RefSeqi NP_001100671.1. NM_001107201.1.
    UniGenei Rn.26557.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004905 ; ENSRNOP00000004905 ; ENSRNOG00000003694 .
    GeneIDi 305066.
    KEGGi rno:305066.
    UCSCi RGD:1306890. rat.

    Organism-specific databases

    CTDi 5629.
    RGDi 1306890. Prox1.

    Phylogenomic databases

    GeneTreei ENSGT00530000063507.
    OMAi QECLSPF.
    OrthoDBi EOG7MSMNK.
    TreeFami TF316638.

    Miscellaneous databases

    NextBioi 654030.

    Family and domain databases

    InterProi IPR007738. Prox1.
    [Graphical view ]
    PANTHERi PTHR12198. PTHR12198. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD3ZU00_RAT
    AccessioniPrimary (citable) accession number: D3ZU00
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3