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D3ZU00 (D3ZU00_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Protein Prox1 Ensembl ENSRNOP00000004905
Gene names
Name:Prox1 Ensembl ENSRNOP00000004905 RGD 1306890
Synonyms:Prox1_predicted EMBL EDL94973.1
ORF Names:rCG_20423 EMBL EDL94973.1
OrganismRattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000004905
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length583 AA.
Sequence statusComplete.
Protein existencePredicted

Ontologies

Keywords
   DomainHomeobox EMBL EDL94973.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaorta smooth muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

atrial cardiac muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

brain development

Inferred from expression pattern PubMed 17368742. Source: RGD

cell fate determination

Inferred from electronic annotation. Source: Ensembl

cerebellar granule cell differentiation

Inferred from electronic annotation. Source: Ensembl

dentate gyrus development

Inferred from electronic annotation. Source: Ensembl

embryonic retina morphogenesis in camera-type eye

Inferred from electronic annotation. Source: Ensembl

endocardium formation

Inferred from electronic annotation. Source: Ensembl

hepatocyte cell migration

Inferred from electronic annotation. Source: Ensembl

hepatocyte differentiation

Inferred from electronic annotation. Source: Ensembl

hepatocyte proliferation

Inferred from electronic annotation. Source: Ensembl

inner ear development

Inferred from electronic annotation. Source: Ensembl

kidney development

Inferred from electronic annotation. Source: Ensembl

lens fiber cell morphogenesis

Inferred from electronic annotation. Source: Ensembl

liver development

Inferred from expression pattern PubMed 16770575. Source: RGD

lung development

Inferred from electronic annotation. Source: Ensembl

lymphangiogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of bile acid biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of viral genome replication

Inferred from electronic annotation. Source: Ensembl

neuronal stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

optic placode formation involved in camera-type eye formation

Inferred from electronic annotation. Source: Ensembl

pancreas development

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell cycle checkpoint

Inferred from electronic annotation. Source: Ensembl

positive regulation of cyclin-dependent protein kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of forebrain neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of heart growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of neural precursor cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of sarcomere organization

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of transcription involved in lymphatic endothelial cell fate commitment

Inferred from electronic annotation. Source: Ensembl

response to nutrient levels

Inferred from expression pattern PubMed 15827236. Source: RGD

skeletal muscle thin filament assembly

Inferred from electronic annotation. Source: Ensembl

venous blood vessel morphogenesis

Inferred from electronic annotation. Source: Ensembl

ventricular cardiac muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

ventricular cardiac myofibril assembly

Inferred from electronic annotation. Source: Ensembl

ventricular septum morphogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 18663461. Source: RGD

   Molecular_functionRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

transcription corepressor activity

Inferred from electronic annotation. Source: Ensembl

transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
D3ZU00 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: BB926DE9CEECA908

FASTA58364,845
        10         20         30         40         50         60 
MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS EQDVEYSVVQ 

        70         80         90        100        110        120 
HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN MNKNGGTEPS FQASGLSSTG 

       130        140        150        160        170        180 
SEVHQEDICS NSSRDSPPEC LSPFGRPTMS QFDVDRLCDE HLRAKRARVE NIIRGMSHSP 

       190        200        210        220        230        240 
SVALRGNENE REMAPQSVSP RESYRENKRK QKLPQQQQQS FQQLVSARKE QKREERRQLK 

       250        260        270        280        290        300 
QQLEDMQKQL RQLQEKFYQV YDSTDSENDE DGDLSEDSMR SEILDARAQD SVGRSDNEMC 

       310        320        330        340        350        360 
ELDPGQFIDR ARALIREQEM AENKPKREGS NKERDHGPNS LQPEGKHLAE TLKQELNTAM 

       370        380        390        400        410        420 
SQVVDTVVKV FSAKPSRQVP QVFPPLQIPQ ARFAVNGENH NFHTANQRLQ CFGDVIIPNP 

       430        440        450        460        470        480 
LDTFGNVQMP SSTDQTEALP LVVRKNSSEQ SASGPATGGH HQPLHQSPLS ATAGFTTPSF 

       490        500        510        520        530        540 
RHPFPLPLMA YPFQSPLGAP SGSFSGKDRA SPESLDLTRD TTSLRTKMSS HHLSHHPCSP 

       550        560        570        580 
AHPPSTAEGL SLSLIKSECG DLQDMSDISP YSGSAMKGYH PIT 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000004905.
[2]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL94973.1.
[3]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL94973.1.
[4]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000004905.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06076839 Genomic DNA. No translation available.
AABR06076840 Genomic DNA. No translation available.
AABR06076841 Genomic DNA. No translation available.
AABR06076842 Genomic DNA. No translation available.
AABR06076843 Genomic DNA. No translation available.
AABR06076844 Genomic DNA. No translation available.
CH473985 Genomic DNA. Translation: EDL94973.1.
RefSeqNP_001100671.1. NM_001107201.1.
UniGeneRn.26557.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000004905; ENSRNOP00000004905; ENSRNOG00000003694.
GeneID305066.
KEGGrno:305066.
UCSCRGD:1306890. rat.

Organism-specific databases

CTD5629.
RGD1306890. Prox1.

Phylogenomic databases

GeneTreeENSGT00530000063507.
OMAQECLSPF.
OrthoDBEOG7MSMNK.
PhylomeDBD3ZU00.
TreeFamTF316638.

Family and domain databases

InterProIPR007738. Prox1.
[Graphical view]
PANTHERPTHR12198. PTHR12198. 1 hit.
ProtoNetSearch...

Other

NextBio654030.

Entry information

Entry nameD3ZU00_RAT
AccessionPrimary (citable) accession number: D3ZU00
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)