D3ZU00 (D3ZU00_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Prospero-related homeobox 1 (Predicted) EMBL EDL94973.1

Submitted name:
Protein Prox1 Ensembl ENSRNOP00000004905

Gene names

Name:	Prox1 Ensembl ENSRNOP00000004905 RGD 1306890
Synonyms:	Prox1_predicted EMBL EDL94973.1
ORF Names:	rCG_20423 EMBL EDL94973.1

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000004905

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Domain	Homeobox EMBL EDL94973.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aorta smooth muscle tissue morphogenesis Inferred from electronic annotation. Source: Compara atrial cardiac muscle tissue morphogenesis Inferred from electronic annotation. Source: Compara brain development Inferred from expression pattern PubMed 17368742. Source: RGD cell fate determination Inferred from electronic annotation. Source: Compara cerebellar granule cell differentiation Inferred from electronic annotation. Source: Compara dentate gyrus development Inferred from electronic annotation. Source: Compara embryonic retina morphogenesis in camera-type eye Inferred from electronic annotation. Source: Compara endocardium formation Inferred from electronic annotation. Source: Compara hepatocyte cell migration Inferred from electronic annotation. Source: Compara hepatocyte differentiation Inferred from electronic annotation. Source: Compara hepatocyte proliferation Inferred from electronic annotation. Source: Compara inner ear development Inferred from electronic annotation. Source: Compara kidney development Inferred from electronic annotation. Source: Compara lens fiber cell morphogenesis Inferred from electronic annotation. Source: Compara liver development Inferred from expression pattern PubMed 16770575. Source: RGD lung development Inferred from electronic annotation. Source: Compara lymphangiogenesis Inferred from electronic annotation. Source: Compara negative regulation of bile acid biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara negative regulation of viral genome replication Inferred from electronic annotation. Source: Compara neuronal stem cell maintenance Inferred from electronic annotation. Source: Compara optic placode formation involved in camera-type eye formation Inferred from electronic annotation. Source: Compara pancreas development Inferred from electronic annotation. Source: Compara positive regulation of S phase of mitotic cell cycle Inferred from electronic annotation. Source: Compara positive regulation of cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell migration Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of forebrain neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of heart growth Inferred from electronic annotation. Source: Compara positive regulation of neural precursor cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of sarcomere organization Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of transcription involved in lymphatic endothelial cell fate commitment Inferred from electronic annotation. Source: Compara response to nutrient levels Inferred from expression pattern PubMed 15827236. Source: RGD skeletal muscle thin filament assembly Inferred from electronic annotation. Source: Compara venous blood vessel morphogenesis Inferred from electronic annotation. Source: Compara ventricular cardiac muscle tissue morphogenesis Inferred from electronic annotation. Source: Compara ventricular cardiac myofibril development Inferred from electronic annotation. Source: Compara ventricular septum morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay PubMed 18663461. Source: RGD
Molecular_function	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: Compara transcription corepressor activity Inferred from electronic annotation. Source: Compara transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D3ZU00 [UniParc]. Last modified April 20, 2010. Version 1. Checksum: BB926DE9CEECA908	FASTA	583	64,845
	10 20 30 40 50 60 MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS EQDVEYSVVQ 70 80 90 100 110 120 HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN MNKNGGTEPS FQASGLSSTG 130 140 150 160 170 180 SEVHQEDICS NSSRDSPPEC LSPFGRPTMS QFDVDRLCDE HLRAKRARVE NIIRGMSHSP 190 200 210 220 230 240 SVALRGNENE REMAPQSVSP RESYRENKRK QKLPQQQQQS FQQLVSARKE QKREERRQLK 250 260 270 280 290 300 QQLEDMQKQL RQLQEKFYQV YDSTDSENDE DGDLSEDSMR SEILDARAQD SVGRSDNEMC 310 320 330 340 350 360 ELDPGQFIDR ARALIREQEM AENKPKREGS NKERDHGPNS LQPEGKHLAE TLKQELNTAM 370 380 390 400 410 420 SQVVDTVVKV FSAKPSRQVP QVFPPLQIPQ ARFAVNGENH NFHTANQRLQ CFGDVIIPNP 430 440 450 460 470 480 LDTFGNVQMP SSTDQTEALP LVVRKNSSEQ SASGPATGGH HQPLHQSPLS ATAGFTTPSF 490 500 510 520 530 540 RHPFPLPLMA YPFQSPLGAP SGSFSGKDRA SPESLDLTRD TTSLRTKMSS HHLSHHPCSP 550 560 570 580 AHPPSTAEGL SLSLIKSECG DLQDMSDISP YSGSAMKGYH PIT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000004905.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL94973.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL94973.1.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000004905.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06076839 Genomic DNA. No translation available. AABR06076840 Genomic DNA. No translation available. AABR06076841 Genomic DNA. No translation available. AABR06076842 Genomic DNA. No translation available. AABR06076843 Genomic DNA. No translation available. AABR06076844 Genomic DNA. No translation available. CH473985 Genomic DNA. Translation: EDL94973.1.
IPI	IPI00363426.
RefSeq	NP_001100671.1. NM_001107201.1.
UniGene	Rn.26557.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000004905; ENSRNOP00000004905; ENSRNOG00000003694.
GeneID	305066.
KEGG	rno:305066.
UCSC	RGD:1306890. rat.
Organism-specific databases
CTD	5629.
RGD	1306890. Prox1.
Phylogenomic databases
GeneTree	ENSGT00530000063507.
OrthoDB	EOG418BMZ.
Family and domain databases
InterPro	IPR007738. Prox1. [Graphical view]
PANTHER	PTHR12198. PTHR12198. 1 hit.
Pfam	PF05044. Prox1. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	654030.

Entry information

Entry name

D3ZU00_RAT

Accession

Primary (citable) accession number: D3ZU00

Entry history

Integrated into UniProtKB/TrEMBL:	April 20, 2010
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)