Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Two pore segment channel 2

Gene

Tpcn2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Submitted name:
Two pore segment channel 2Imported
Submitted name:
Two pore segment channel 2 (Predicted), isoform CRA_aImported
Gene namesi
Name:Tpcn2Imported
Synonyms:Tpcn2_predictedImported
ORF Names:rCG_47337Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311779. Tpcn2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei201 – 223HelicalSequence analysisAdd BLAST23
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Transmembranei396 – 415HelicalSequence analysisAdd BLAST20
Transmembranei427 – 451HelicalSequence analysisAdd BLAST25
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21
Transmembranei503 – 520HelicalSequence analysisAdd BLAST18
Transmembranei541 – 561HelicalSequence analysisAdd BLAST21
Transmembranei630 – 653HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000013387.
ExpressionAtlasiD3ZTJ6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051739.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 255Ion_transInterPro annotationAdd BLAST181
Domaini392 – 656Ion_transInterPro annotationAdd BLAST265

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410KCTV. Eukaryota.
ENOG4111V21. LUCA.
GeneTreeiENSGT00530000063660.
KOiK14077.
OMAiRYRSPPW.
OrthoDBiEOG091G045K.

Family and domain databases

InterProiView protein in InterPro
IPR005821. Ion_trans_dom.
PfamiView protein in Pfam
PF00520. Ion_trans. 2 hits.

Sequencei

Sequence statusi: Complete.

D3ZTJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEAQPLLG RDRGGGQAHS GADQELCIDQ AVVFIEDAIK YRSIYHRLDA
60 70 80 90 100
GSLWLYRWYY SNVCQRVLGF TIFLILALAF VEVPSSFTRT ADVRYRSQPW
110 120 130 140 150
QPPCGLTETI EALCLLVFLA DLSVKGYLVG QAQLQQNLWL LAYFVVLVVS
160 170 180 190 200
VVDWIVSLSL NCEESLRVRR LLRPFFLLQN SSMMKKTLKC IRWSLPEMAS
210 220 230 240 250
VGLLLTIHLC LFTVIGMLLF TIAEKDEAQN KERLTYFRNL PEALTSLLVL
260 270 280 290 300
LTTSNNPDGS LFLMNLLTAI IYNQFRGYLM KSLQTSLFRR RLGARAAYEV
310 320 330 340 350
LTLQAGPNGT TSELVGVNPE NFLRVLQKTQ LNKIHKQAII QKVHSYEGRP
360 370 380 390 400
ILADEFQKLF DEVDKGIVKE RPPKPQYQSP FLQTAQFIFS HRYFDYLGNL
410 420 430 440 450
IALGNLLSIC VFLVLDSNLL PGERNDFVLG ILNYIFILYY LLELLFKVFA
460 470 480 490 500
LGLRGYLFYH SNVFDGLLTI ILLVLEISTL AVYRLPHPGW KPEQYGPLSL
510 520 530 540 550
WDMTRLVNIL IVIRFLRIIP SIKPTAVVAS TILGLIQNLR AFGGILVVVY
560 570 580 590 600
YVFAMIGINL FRGVIVPPGN SSLVPDNSSA PCGSFEQLGY WPNNFDDFAA
610 620 630 640 650
ALITLWDVMV VNNWQVILEA YKHYSGPWSM VYFVLWWLVS SVIWINLFLA
660 670 680 690 700
LLLENFLHRW DPQGHKQLLV GTKQITYEMS VELMFRDILE EPKEEELMEK
710
LHKHPHLHLC R
Length:711
Mass (Da):81,395
Last modified:April 20, 2010 - v1
Checksum:i2F3930DDB7D4EEEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098981 Genomic DNA. No translation available.
CH473953 Genomic DNA. Translation: EDM12274.1.
RefSeqiNP_001101036.1. NM_001107566.1.
UniGeneiRn.138237.

Genome annotation databases

EnsembliENSRNOT00000054857; ENSRNOP00000051739; ENSRNOG00000013387.
GeneIDi309139.
KEGGirno:309139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098981 Genomic DNA. No translation available.
CH473953 Genomic DNA. Translation: EDM12274.1.
RefSeqiNP_001101036.1. NM_001107566.1.
UniGeneiRn.138237.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054857; ENSRNOP00000051739; ENSRNOG00000013387.
GeneIDi309139.
KEGGirno:309139.

Organism-specific databases

CTDi219931.
RGDi1311779. Tpcn2.

Phylogenomic databases

eggNOGiENOG410KCTV. Eukaryota.
ENOG4111V21. LUCA.
GeneTreeiENSGT00530000063660.
KOiK14077.
OMAiRYRSPPW.
OrthoDBiEOG091G045K.

Enzyme and pathway databases

ReactomeiR-RNO-2672351. Stimuli-sensing channels.

Gene expression databases

BgeeiENSRNOG00000013387.
ExpressionAtlasiD3ZTJ6. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR005821. Ion_trans_dom.
PfamiView protein in Pfam
PF00520. Ion_trans. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZTJ6_RAT
AccessioniPrimary (citable) accession number: D3ZTJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 12, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.