ID   D3ZSA9_RAT              Unreviewed;      1230 AA.
AC   D3ZSA9;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   27-MAR-2024, entry version 100.
DE   SubName: Full=Nodal modulator 1 {ECO:0000313|Ensembl:ENSRNOP00000028680.6};
GN   Name=Nomo1 {ECO:0000313|Ensembl:ENSRNOP00000028680.6,
GN   ECO:0000313|RGD:1305240};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000028680.6, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000028680.6, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000028680.6,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000028680.6}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000028680.6};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}.
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DR   RefSeq; XP_006229170.1; XM_006229108.3.
DR   AlphaFoldDB; D3ZSA9; -.
DR   STRING; 10116.ENSRNOP00000028680; -.
DR   PaxDb; 10116-ENSRNOP00000028680; -.
DR   PeptideAtlas; D3ZSA9; -.
DR   Ensembl; ENSRNOT00000028680.6; ENSRNOP00000028680.6; ENSRNOG00000021118.6.
DR   GeneID; 361578; -.
DR   UCSC; RGD:1305240; rat.
DR   AGR; RGD:1305240; -.
DR   CTD; 23420; -.
DR   RGD; 1305240; Nomo1.
DR   VEuPathDB; HostDB:ENSRNOG00000021118; -.
DR   eggNOG; KOG1948; Eukaryota.
DR   GeneTree; ENSGT00390000000089; -.
DR   HOGENOM; CLU_007543_2_0_1; -.
DR   InParanoid; D3ZSA9; -.
DR   OMA; GWSFEPE; -.
DR   OrthoDB; 4529700at2759; -.
DR   TreeFam; TF313696; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000021118; Expressed in skeletal muscle tissue and 19 other cell types or tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0160064; C:multi-pass translocon complex; ISO:RGD.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0043022; F:ribosome binding; ISO:RGD.
DR   GO; GO:0160063; P:multi-pass transmembrane protein insertion into ER membrane; ISO:RGD.
DR   Gene3D; 2.60.40.1120; Carboxypeptidase-like, regulatory domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR013784; Carb-bd-like_fold.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR041033; Prealbumin-like.
DR   PANTHER; PTHR23303; CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING; 1.
DR   PANTHER; PTHR23303:SF14; NODAL MODULATOR 1-RELATED; 1.
DR   Pfam; PF13620; CarboxypepD_reg; 1.
DR   Pfam; PF17802; SpaA; 1.
DR   SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR   SUPFAM; SSF49452; Starch-binding domain-like; 3.
PE   4: Predicted;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..1230
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035241665"
FT   DOMAIN          866..919
FT                   /note="Prealbumin-like fold"
FT                   /evidence="ECO:0000259|Pfam:PF17802"
FT   REGION          708..733
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1206..1230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        708..730
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1230 AA;  135199 MW;  6CB3E1E48C4EE92A CRC64;
     MRAGRCAAVL LLLLLSGPGR AIGSEDIVVG CGGFVKSDVE INYSLIEIKL YTKHGTLKYQ
     TDCAPNNGYF MIPLYDKGDF ILKIEPPLGW SFEPTNVELH VDGVSDVCTR GGDINFVFTG
     FSVNGKVLSK GQPLGPAGVQ VSLRSTGADS KIQSTVTQPG GKFAFFKVLP GDYEILATHP
     TWALKEASTT VRVTNSNANA AGPLIVAGYN VSGSVRSDGE PMKGVKFLLF SSLVNKEDVL
     GCNVSPVSGF QPPDESLVYL CYAVSKEDGS FSFYSLPSGG YTVVPFYRGE RITFDVAPSR
     LDFTVEHDSL RIEPVFHVMG FSVTGRVLNG PDGEGVPEAV VTLNNQIKVR TKADGSFRLE
     NITTGTYTIH AQKEHLYFDM VTIKIAPNTP QLADLIATGF SICGQISIIR SPDTIKQMNK
     YKVVLSSQDK DKALVTVETD AHGSFCFKAK PGIYKVQVVV PEAETRAGLM LKPQTFPITV
     TNKPVMDVAF VQFLASVSGK VSCLDTCGDL LVTLQSLSRQ GEKRSLQLSG KVNSMTFTFD
     KVLPGKYKIS IMHEDWCWRN KSLEVEVLED DVSAVEFRQT GYMLRCALSH AITLEFHQDG
     NGPENVGIYN LSRGVNRFCL SKPGVYKVTP RSCHRFEQAF YTYDTSSPSI LTLTAIRHHV
     LGTIITDKMM DVTVTIKSSI DSEPALVLGP LKSAQELRRE QQLAEIETRR QEREKNGKEE
     GEEGRARPPG QEMVDELQGP FSYDFSYWAR CGEKITVTPS SKELLFYPPS MEATVSGESC
     PGKLIEIHGK AGLFLEGQIH PELEGVEIVI SEKGASSPLI TVFTDDKGAY SVGPLHSDLE
     YTVTSQKEGF VLTAVEGTVG DFKAYALAGV SFEIKAEDDQ PLPGVLLSLS GGVFRSNLLT
     QDNGILTFSN LSPGQYYFKP MMKEFRFEPS SQMIEVQEGQ NLRITITGFR TAYSCYGTVS
     SLNGEPEQGV AVEAVGQKDC SIYGEDTVTD EEGKFRLRGL LPGCMYHVQL KAEGNDHIER
     ALPHHRVIEV GNNDVDDVNI IVFRQINQFD LSGNVITSSE YLSTLWVKLY KSESLDNPIQ
     TVSLGQSLFF HFPPLLRDGE NYVVLLDSTL PRSQYDYVLP QVSFAAVGYH KHITLVFSPT
     WSMSENLQGV TAIPLQRKLP EQDIAQGSYI ALPLTLLLLL AGYNHDKLIP LLLQLTSRLQ
     GVRALGQAAS DSSGPEDMKR QTKKQKTRRT
//