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Protein

Metalloendopeptidase OMA1, mitochondrial

Gene

Oma1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.By similarity

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi306Zinc; catalyticBy similarity1
Active sitei307By similarity1
Metal bindingi310Zinc; catalyticBy similarity1
Metal bindingi371Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-169911 Regulation of Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloendopeptidase OMA1, mitochondrial (EC:3.4.24.-)
Alternative name(s):
Overlapping with the m-AAA protease 1 homolog
Gene namesi
Name:Oma1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1304821 Oma1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 41MitochondrionSequence analysisAdd BLAST41
ChainiPRO_000041751942 – 504Metalloendopeptidase OMA1, mitochondrialBy similarityAdd BLAST463

Post-translational modificationi

In normal conditions, cleaved into an inactive 40 kDa form. Following CCCP treatment that induces loss of mitochondrial membrane potential, the 40 kDa form is reduced in favor of an active 60 kDa form (By similarity).By similarity

Proteomic databases

PaxDbiD3ZS74
PeptideAtlasiD3ZS74
PRIDEiD3ZS74

PTM databases

CarbonylDBiD3ZS74

Expressioni

Gene expression databases

BgeeiENSRNOG00000007214
GenevisibleiD3ZS74 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009515

Structurei

3D structure databases

ProteinModelPortaliD3ZS74
SMRiD3ZS74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M48 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2661 Eukaryota
COG0501 LUCA
GeneTreeiENSGT00390000007027
InParanoidiD3ZS74
OMAiFLTMIWA
OrthoDBiEOG091G087J
PhylomeDBiD3ZS74
TreeFamiTF329133

Family and domain databases

InterProiView protein in InterPro
IPR001915 Peptidase_M48
PfamiView protein in Pfam
PF01435 Peptidase_M48, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3ZS74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLYGLQSA TRNQFLSGVN TLARRRTWTP PAGCPLASRL PAVNANWGLS
60 70 80 90 100
TVSHCYSVIL LPRNLHFCRT LKNKRSRCLS SAQSKEMGVL TYNWTVWGDA
110 120 130 140 150
SCSPNYAAIR EVRSFHTSAP RQAAPVPLLM LILKPVQKLL AIIVGRGIRK
160 170 180 190 200
WWQALPPDKK ALFKDSVKRN KWRLLLGLSA FGLLFVVFYF THLEVSPVTG
210 220 230 240 250
RSKLLLVGKE HFRLLSDLEY EVWMEEFKND LLPEEDPRYL TVKKVVYHLT
260 270 280 290 300
QCNQDVPGVS EINWVVHVVH SPKVNAFVLP NGQVFVFTGL LNSVTDMHQL
310 320 330 340 350
SFLLGHEIAH AVLGHAAEKA SLVHLLDFLG MIFLTMIWAI CPRDSLAVLG
360 370 380 390 400
QWIQSKLQEY MFDRPYSRTL EAEADKIGLQ LAAKACVDVR ASSVFWQQME
410 420 430 440 450
FSESLHGYPK LPEWLSTHPS HGNRAEYLDR LIPQALKLRE VCNCPPLSGP
460 470 480 490 500
DPRLLFRLTV KHLLEDSEKE DLNITVKKQK PDALPIQKQE QIPLTYALGK

RTAG
Length:504
Mass (Da):57,145
Last modified:April 20, 2010 - v1
Checksum:iD7456DE65BC9ECDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473998 Genomic DNA Translation: EDL97870.1
RefSeqiNP_001100139.1, NM_001106669.1
XP_006238537.1, XM_006238475.3
UniGeneiRn.14712

Genome annotation databases

EnsembliENSRNOT00000009516; ENSRNOP00000009515; ENSRNOG00000007214
GeneIDi298282
KEGGirno:298282
UCSCiRGD:1304821 rat

Similar proteinsi

Entry informationi

Entry nameiOMA1_RAT
AccessioniPrimary (citable) accession number: D3ZS74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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