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D3ZS31

- D3ZS31_RAT

UniProt

D3ZS31 - D3ZS31_RAT

Protein
Submitted name:

Lethal(2) giant larvae protein homolog 1

Gene

Rgl1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factorSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_196408. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Lethal(2) giant larvae protein homolog 1Imported
    Submitted name:
    Ral guanine nucleotide dissociation stimulator,-like 1 (Predicted), isoform CRA_aImported
    Gene namesi
    Name:Rgl1Imported
    Synonyms:Rgl1_predictedImported
    ORF Names:rCG_46416Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi1308947. Rgl1.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Family & Domainsi

    Sequence similaritiesi

    Contains N-terminal Ras-GEF domain.SAAS annotation
    Contains Ras-GEF domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115163.
    KOiK17635.
    OMAiKRGCWSN.
    OrthoDBiEOG76DTRS.

    Family and domain databases

    Gene3Di1.10.840.10. 2 hits.
    InterProiIPR000159. Ras-assoc.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00788. RA. 1 hit.
    PF00617. RasGEF. 1 hit.
    [Graphical view]
    SMARTiSM00314. RA. 1 hit.
    SM00147. RasGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50200. RA. 1 hit.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3ZS31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPVRSGPSK LAHWRSLWRT YGNLTGPHWE DDGSQSSPES KAVIRNAIAS    50
    ILRAWLDQCA EDFREPPHFP CLQKLLEYLK QMMPGSDPER RAQNLLEQFQ 100
    KQDVDSDNGL LNTISFSPEE EEELESGGSA ELTTFSEDLV AEQLTYMDAQ 150
    LFKKVVPHHC LGCVWSRRDR KENKHLAPTI RATISQFNAL TKCVVSTILG 200
    SKDLKTQQRA RVIEKWINIA HECRILKNFS SLRAIVSALQ SNSIYRLKKA 250
    WAAVPKDRML MFEELSEIFS DHNNHLTSRE LLMKEGTSKF ANLDSSVKEN 300
    QKRTQRRLQL QKDMGVMQGT VPYLGTFLTD LTMLDTALQD YIEGGLINFE 350
    KRRREFEVIA QIKLLQSACN SYCMSPDQKF IQWFQRQQLL TEEESYALSC 400
    EIEAAADAST TSPKPRKSMV KRLSLLFLGS DLIPGSTPTK EQPKSTASGS 450
    SGESMDSVSV SSCESNHSEA EEGSATPMDT PDEPQKKLSE SSSSCSSIHS 500
    MDTNSSGMSS LINPLSSPPA CNNNPKMHKR SVSVTSITST VLPPVYNQQN 550
    EDTCIIRISV EDNNGNMYKS IMLTSQDKTP AVIQRAMSKH NLESDPAEEY 600
    ELVQVISEDK ELVIPDSANV FYAMNSQVNF DFILRKKSSV EEQVKMRSRT 650
    SLTMPRTAKR GCWSNRHSKV TL 672
    Length:672
    Mass (Da):75,698
    Last modified:April 20, 2010 - v1
    Checksum:i6680D8BDDB97F90F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06075449 Genomic DNA. No translation available.
    AABR06075450 Genomic DNA. No translation available.
    AABR06075451 Genomic DNA. No translation available.
    AABR06075452 Genomic DNA. No translation available.
    AABR06075453 Genomic DNA. No translation available.
    AABR06075454 Genomic DNA. No translation available.
    AABR06075455 Genomic DNA. No translation available.
    AABR06075456 Genomic DNA. No translation available.
    AABR06075457 Genomic DNA. No translation available.
    CH473958 Genomic DNA. Translation: EDM09558.1.
    RefSeqiNP_001099427.1. NM_001105957.1.
    UniGeneiRn.28005.

    Genome annotation databases

    EnsembliENSRNOT00000067135; ENSRNOP00000063014; ENSRNOG00000002347.
    GeneIDi289080.
    KEGGirno:289080.
    UCSCiRGD:1308947. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06075449 Genomic DNA. No translation available.
    AABR06075450 Genomic DNA. No translation available.
    AABR06075451 Genomic DNA. No translation available.
    AABR06075452 Genomic DNA. No translation available.
    AABR06075453 Genomic DNA. No translation available.
    AABR06075454 Genomic DNA. No translation available.
    AABR06075455 Genomic DNA. No translation available.
    AABR06075456 Genomic DNA. No translation available.
    AABR06075457 Genomic DNA. No translation available.
    CH473958 Genomic DNA. Translation: EDM09558.1 .
    RefSeqi NP_001099427.1. NM_001105957.1.
    UniGenei Rn.28005.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000067135 ; ENSRNOP00000063014 ; ENSRNOG00000002347 .
    GeneIDi 289080.
    KEGGi rno:289080.
    UCSCi RGD:1308947. rat.

    Organism-specific databases

    CTDi 23179.
    RGDi 1308947. Rgl1.

    Phylogenomic databases

    GeneTreei ENSGT00740000115163.
    KOi K17635.
    OMAi KRGCWSN.
    OrthoDBi EOG76DTRS.

    Enzyme and pathway databases

    Reactomei REACT_196408. PPARA activates gene expression.

    Miscellaneous databases

    NextBioi 629181.

    Family and domain databases

    Gene3Di 1.10.840.10. 2 hits.
    InterProi IPR000159. Ras-assoc.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00788. RA. 1 hit.
    PF00617. RasGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00314. RA. 1 hit.
    SM00147. RasGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50200. RA. 1 hit.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD3ZS31_RAT
    AccessioniPrimary (citable) accession number: D3ZS31
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3