Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ethanolamine kinase 2

Gene

Etnk2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity.

Catalytic activityi

ATP + ethanolamine = ADP + O-phosphoethanolamine.

Pathwayi: phosphatidylethanolamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Choline kinase alpha (Chka), Choline/ethanolamine kinase (Chkb), Ethanolamine kinase 2 (Etnk2)
  2. Ethanolamine-phosphate cytidylyltransferase (Pcyt2)
  3. Choline/ethanolaminephosphotransferase 1 (Cept1)
This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1483213. Synthesis of PE.
UniPathwayiUPA00558; UER00741.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolamine kinase 2 (EC:2.7.1.82)
Short name:
EKI 2
Alternative name(s):
Ethanolamine kinase-like protein
Gene namesi
Name:Etnk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1305304. Etnk2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Ethanolamine kinase 2PRO_0000395963Add
BLAST

Proteomic databases

PaxDbiD3ZRW8.

Expressioni

Gene expression databases

ExpressionAtlasiD3ZRW8. baseline and differential.
GenevisibleiD3ZRW8. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061210.

Family & Domainsi

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

eggNOGiKOG4720. Eukaryota.
COG0510. LUCA.
GeneTreeiENSGT00530000062991.
InParanoidiD3ZRW8.
KOiK00894.
PhylomeDBiD3ZRW8.
TreeFamiTF313549.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZRW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPPSAPVP CSPFYLRRQE ACPQCSWSME EKAVASASCW EPPGPPRAAV
60 70 80 90 100
PCFAIAVDQD DILPGALRLI RELRPHWKPE QVRTKRFKDG ITNKLLACYV
110 120 130 140 150
EEDMRDCVLV RVYGEWTELL VDRENEIRNF QLLRAHGCAP KLYCTFQNGL
160 170 180 190 200
CYEYMQGVAL GPEHIREPQL FRLIALEMAK IHTIHANGSL PKPTLWHKMH
210 220 230 240 250
RYFTLVKDEI SPSLSADVPK VEVLEQELAW LKEHLSQLDS PVVFCHNDLL
260 270 280 290 300
CKNIIYDSDK GHVRFIDYEY AGYNYQAFDI GNHFNEFAGV NEVDYCRYPA
310 320 330 340 350
REIQLQWLRY YLEAQKGTAA SPREVERLYA QVNKFALASH FFWALWALIQ
360 370 380
NQYSTINFDF LRYAVIRFNQ YFKVKPQVSA LEMPK
Length:385
Mass (Da):44,734
Last modified:April 20, 2010 - v1
Checksum:iE27F27544301550B
GO

Sequence cautioni

The sequence EDM09769.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EDM09770.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473958 Genomic DNA. Translation: EDM09769.1. Sequence problems.
CH473958 Genomic DNA. Translation: EDM09770.1. Sequence problems.
RefSeqiNP_001101813.1. NM_001108343.1.
UniGeneiRn.65516.

Genome annotation databases

EnsembliENSRNOT00000076924; ENSRNOP00000068193; ENSRNOG00000028368.
GeneIDi360843.
KEGGirno:360843.
UCSCiRGD:1305304. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473958 Genomic DNA. Translation: EDM09769.1. Sequence problems.
CH473958 Genomic DNA. Translation: EDM09770.1. Sequence problems.
RefSeqiNP_001101813.1. NM_001108343.1.
UniGeneiRn.65516.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061210.

Proteomic databases

PaxDbiD3ZRW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000076924; ENSRNOP00000068193; ENSRNOG00000028368.
GeneIDi360843.
KEGGirno:360843.
UCSCiRGD:1305304. rat.

Organism-specific databases

CTDi55224.
RGDi1305304. Etnk2.

Phylogenomic databases

eggNOGiKOG4720. Eukaryota.
COG0510. LUCA.
GeneTreeiENSGT00530000062991.
InParanoidiD3ZRW8.
KOiK00894.
PhylomeDBiD3ZRW8.
TreeFamiTF313549.

Enzyme and pathway databases

UniPathwayiUPA00558; UER00741.
ReactomeiR-RNO-1483213. Synthesis of PE.

Miscellaneous databases

NextBioi674322.
PROiD3ZRW8.

Gene expression databases

ExpressionAtlasiD3ZRW8. baseline and differential.
GenevisibleiD3ZRW8. RN.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiEKI2_RAT
AccessioniPrimary (citable) accession number: D3ZRW8
Secondary accession number(s): D4A6J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: April 20, 2010
Last modified: November 11, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.