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D3ZRK7

- D3ZRK7_RAT

UniProt

D3ZRK7 - D3ZRK7_RAT

Protein
Submitted name:

Cell division cycle 6 homolog (S. cerevisiae) (Predicted), isoform CRA_a

Gene

Cdc6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. chromatin binding Source: Ensembl
    3. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. positive regulation of chromosome segregation Source: Ensembl
    3. positive regulation of cytokinesis Source: Ensembl
    4. regulation of mitotic metaphase/anaphase transition Source: Ensembl

    Keywords - Biological processi

    Cell cycle, Cell divisionImported

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196414. G1/S-Specific Transcription.
    REACT_199174. G0 and Early G1.
    REACT_204904. Activation of ATR in response to replication stress.
    REACT_206997. CDT1 association with the CDC6:ORC:origin complex.
    REACT_208829. Assembly of the pre-replicative complex.
    REACT_209879. Activation of the pre-replicative complex.
    REACT_211117. Orc1 removal from chromatin.
    REACT_212486. CDK-mediated phosphorylation and removal of Cdc6.
    REACT_212543. Removal of licensing factors from origins.
    REACT_213976. CDC6 association with the ORC:origin complex.
    REACT_223712. Association of licensing factors with the pre-replicative complex.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cell division cycle 6 homolog (S. cerevisiae) (Predicted), isoform CRA_aImported
    Submitted name:
    Protein Cdc6Imported
    Gene namesi
    Name:Cdc6Imported
    Synonyms:Cdc6_predictedImported
    ORF Names:rCG_34910Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1309157. Cdc6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl
    3. spindle midzone Source: Ensembl
    4. spindle pole Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000063498.
    KOiK02213.
    OMAiPYTRNQI.
    OrthoDBiEOG7QG44J.
    TreeFamiTF101051.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR015163. Cdc6_C_dom.
    IPR016314. Cell_div_Cdc6/18.
    IPR027417. P-loop_NTPase.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF09079. Cdc6_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001767. Cdc6. 1 hit.
    SMARTiSM00382. AAA. 1 hit.
    SM01074. Cdc6_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D3ZRK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPQTRSQTQA TIDFPKKKQS KTLSKTNSRD SEVKLRNVQP VPTTPCADIK    50
    ILPLSPRKRL GDDNLCNTPH LSPCSPPKLG RKENGPPRSH TRKGCRLIFD 100
    DELAVKASAP KEQDRVPQHQ ILSSAQRGQE SETNPEQKCP PEKESACMRL 150
    FKQEGTCYQQ AKLVLNTAVP DRLPAREQEM GVIRDFLKEH ICGKKAGSLY 200
    LSGAPGTGKT ACLSRILQDF KKEVKGFKTI VLNCMSLRNA QAVFPAIAQE 250
    IGREELCRPT GKDLMRKLEK HLTAERGPMI VLVLDEMDQL DSKGQDVLYT 300
    LFEWPWLSNS RLVLIGIANT LDLTDRILPR LEAREGCKPK LLNFPPYTRN 350
    QIAAILQDRL SQVSKDQVLD SAAIQFCARK VSAVSGDIRK ALDVCRRAIE 400
    IVESDVRSQT VLKPLSECKS PCESLVPKRV GLAHISQVIS GVDGNRVTLS 450
    QENTQDSLPL QQKILVCSLL LLTKRLKIKE VTLGKLYEAY SSVCRKQQVA 500
    AVDQSECLSL SGLLESRGIV GLKKNKESRL TKVSLKIEEK EIEHVLKGKA 550
    FIGNILAAGL P 561
    Length:561
    Mass (Da):62,313
    Last modified:April 20, 2010 - v1
    Checksum:iDB442EA93D249296
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06065511 Genomic DNA. No translation available.
    CH473948 Genomic DNA. Translation: EDM05961.1.
    CH473948 Genomic DNA. Translation: EDM05962.1.
    RefSeqiNP_001101768.1. NM_001108298.1.
    XP_006247416.1. XM_006247354.1.
    UniGeneiRn.219688.

    Genome annotation databases

    EnsembliENSRNOT00000038228; ENSRNOP00000032177; ENSRNOG00000027787.
    GeneIDi360621.
    KEGGirno:360621.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06065511 Genomic DNA. No translation available.
    CH473948 Genomic DNA. Translation: EDM05961.1 .
    CH473948 Genomic DNA. Translation: EDM05962.1 .
    RefSeqi NP_001101768.1. NM_001108298.1.
    XP_006247416.1. XM_006247354.1.
    UniGenei Rn.219688.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000038228 ; ENSRNOP00000032177 ; ENSRNOG00000027787 .
    GeneIDi 360621.
    KEGGi rno:360621.

    Organism-specific databases

    CTDi 990.
    RGDi 1309157. Cdc6.

    Phylogenomic databases

    GeneTreei ENSGT00530000063498.
    KOi K02213.
    OMAi PYTRNQI.
    OrthoDBi EOG7QG44J.
    TreeFami TF101051.

    Enzyme and pathway databases

    Reactomei REACT_196414. G1/S-Specific Transcription.
    REACT_199174. G0 and Early G1.
    REACT_204904. Activation of ATR in response to replication stress.
    REACT_206997. CDT1 association with the CDC6:ORC:origin complex.
    REACT_208829. Assembly of the pre-replicative complex.
    REACT_209879. Activation of the pre-replicative complex.
    REACT_211117. Orc1 removal from chromatin.
    REACT_212486. CDK-mediated phosphorylation and removal of Cdc6.
    REACT_212543. Removal of licensing factors from origins.
    REACT_213976. CDC6 association with the ORC:origin complex.
    REACT_223712. Association of licensing factors with the pre-replicative complex.

    Miscellaneous databases

    NextBioi 673491.
    PROi D3ZRK7.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR015163. Cdc6_C_dom.
    IPR016314. Cell_div_Cdc6/18.
    IPR027417. P-loop_NTPase.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF09079. Cdc6_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001767. Cdc6. 1 hit.
    SMARTi SM00382. AAA. 1 hit.
    SM01074. Cdc6_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD3ZRK7_RAT
    AccessioniPrimary (citable) accession number: D3ZRK7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3