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Protein
Submitted name:

Cell division cycle 6 homolog (S. cerevisiae) (Predicted), isoform CRA_a

Gene

Cdc6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. chromatin binding Source: Ensembl

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. positive regulation of chromosome segregation Source: Ensembl
  3. positive regulation of cytokinesis Source: Ensembl
  4. regulation of mitotic metaphase/anaphase transition Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell divisionImported

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196414. G1/S-Specific Transcription.
REACT_199174. G0 and Early G1.
REACT_204904. Activation of ATR in response to replication stress.
REACT_206997. CDT1 association with the CDC6:ORC:origin complex.
REACT_208829. Assembly of the pre-replicative complex.
REACT_209879. Activation of the pre-replicative complex.
REACT_211117. Orc1 removal from chromatin.
REACT_212486. CDK-mediated phosphorylation and removal of Cdc6.
REACT_212543. Removal of licensing factors from origins.
REACT_213976. CDC6 association with the ORC:origin complex.
REACT_223712. Association of licensing factors with the pre-replicative complex.
REACT_249225. E2F mediated regulation of DNA replication.

Names & Taxonomyi

Protein namesi
Submitted name:
Cell division cycle 6 homolog (S. cerevisiae) (Predicted), isoform CRA_aImported
Submitted name:
Protein Cdc6Imported
Gene namesi
Name:Cdc6Imported
Synonyms:Cdc6_predictedImported
ORF Names:rCG_34910Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1309157. Cdc6.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. nucleus Source: Ensembl
  3. spindle midzone Source: Ensembl
  4. spindle pole Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063498.
KOiK02213.
OMAiTPHLPPC.
OrthoDBiEOG7QG44J.
TreeFamiTF101051.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C_dom.
IPR016314. Cell_div_Cdc6/18.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09079. Cdc6_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001767. Cdc6. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

D3ZRK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQTRSQTQA TIDFPKKKQS KTLSKTNSRD SEVKLRNVQP VPTTPCADIK
60 70 80 90 100
ILPLSPRKRL GDDNLCNTPH LSPCSPPKLG RKENGPPRSH TRKGCRLIFD
110 120 130 140 150
DELAVKASAP KEQDRVPQHQ ILSSAQRGQE SETNPEQKCP PEKESACMRL
160 170 180 190 200
FKQEGTCYQQ AKLVLNTAVP DRLPAREQEM GVIRDFLKEH ICGKKAGSLY
210 220 230 240 250
LSGAPGTGKT ACLSRILQDF KKEVKGFKTI VLNCMSLRNA QAVFPAIAQE
260 270 280 290 300
IGREELCRPT GKDLMRKLEK HLTAERGPMI VLVLDEMDQL DSKGQDVLYT
310 320 330 340 350
LFEWPWLSNS RLVLIGIANT LDLTDRILPR LEAREGCKPK LLNFPPYTRN
360 370 380 390 400
QIAAILQDRL SQVSKDQVLD SAAIQFCARK VSAVSGDIRK ALDVCRRAIE
410 420 430 440 450
IVESDVRSQT VLKPLSECKS PCESLVPKRV GLAHISQVIS GVDGNRVTLS
460 470 480 490 500
QENTQDSLPL QQKILVCSLL LLTKRLKIKE VTLGKLYEAY SSVCRKQQVA
510 520 530 540 550
AVDQSECLSL SGLLESRGIV GLKKNKESRL TKVSLKIEEK EIEHVLKGKA
560
FIGNILAAGL P
Length:561
Mass (Da):62,313
Last modified:April 20, 2010 - v1
Checksum:iDB442EA93D249296
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06065511 Genomic DNA. No translation available.
CH473948 Genomic DNA. Translation: EDM05961.1.
CH473948 Genomic DNA. Translation: EDM05962.1.
RefSeqiNP_001101768.1. NM_001108298.1.
XP_006247416.1. XM_006247354.2.
UniGeneiRn.219688.

Genome annotation databases

EnsembliENSRNOT00000038228; ENSRNOP00000032177; ENSRNOG00000027787.
GeneIDi360621.
KEGGirno:360621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06065511 Genomic DNA. No translation available.
CH473948 Genomic DNA. Translation: EDM05961.1.
CH473948 Genomic DNA. Translation: EDM05962.1.
RefSeqiNP_001101768.1. NM_001108298.1.
XP_006247416.1. XM_006247354.2.
UniGeneiRn.219688.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038228; ENSRNOP00000032177; ENSRNOG00000027787.
GeneIDi360621.
KEGGirno:360621.

Organism-specific databases

CTDi990.
RGDi1309157. Cdc6.

Phylogenomic databases

GeneTreeiENSGT00530000063498.
KOiK02213.
OMAiTPHLPPC.
OrthoDBiEOG7QG44J.
TreeFamiTF101051.

Enzyme and pathway databases

ReactomeiREACT_196414. G1/S-Specific Transcription.
REACT_199174. G0 and Early G1.
REACT_204904. Activation of ATR in response to replication stress.
REACT_206997. CDT1 association with the CDC6:ORC:origin complex.
REACT_208829. Assembly of the pre-replicative complex.
REACT_209879. Activation of the pre-replicative complex.
REACT_211117. Orc1 removal from chromatin.
REACT_212486. CDK-mediated phosphorylation and removal of Cdc6.
REACT_212543. Removal of licensing factors from origins.
REACT_213976. CDC6 association with the ORC:origin complex.
REACT_223712. Association of licensing factors with the pre-replicative complex.
REACT_249225. E2F mediated regulation of DNA replication.

Miscellaneous databases

NextBioi673491.
PROiD3ZRK7.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C_dom.
IPR016314. Cell_div_Cdc6/18.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09079. Cdc6_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001767. Cdc6. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD3ZRK7_RAT
AccessioniPrimary (citable) accession number: D3ZRK7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.