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Protein
Submitted name:

Mucolipin 1

Gene

Mcoln1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-3295583 TRP channels
R-RNO-917977 Transferrin endocytosis and recycling

Names & Taxonomyi

Protein namesi
Submitted name:
Mucolipin 1Imported
Submitted name:
Mucolipin 1 (Predicted), isoform CRA_aImported
Gene namesi
Name:Mcoln1Imported
Synonyms:Mcoln1_predictedImported
ORF Names:rCG_58948Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1308953 Mcoln1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 85HelicalSequence analysisAdd BLAST20
Transmembranei299 – 321HelicalSequence analysisAdd BLAST23
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Transmembranei425 – 447HelicalSequence analysisAdd BLAST23
Transmembranei496 – 517HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiD3ZRF9

Expressioni

Gene expression databases

BgeeiENSRNOG00000000975

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001290

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini385 – 524PKD_channelInterPro annotationAdd BLAST140

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3733 Eukaryota
ENOG410Z1HH LUCA
GeneTreeiENSGT00390000017126
KOiK04992
OMAiPANDTFN
OrthoDBiEOG091G026A

Family and domain databases

InterProiView protein in InterPro
IPR013122 PKD1_2_channel
PfamiView protein in Pfam
PF08016 PKD_channel, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZRF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAAGRRGS ETEQLLTPNP GYGTQAGTSP APTTPPEEED LRRRLKYFFM
60 70 80 90 100
SPCDKFRAKG RKPCKLMLQV VKILVVTVQL ILFGLSNQLV VTFREENTIA
110 120 130 140 150
FRHLFLLGYS DGSDDTFAAY TREQLYQAIF YAVDQYLTLP EISLGRYAYV
160 170 180 190 200
RGGGGPWANG SALALCQRYY HRGHVDPAND TFDIDPRVVT DCIQVDPPDR
210 220 230 240 250
PPDIPSEDLD FLDGSTSYKN ITLKFHKLIN VTIHFQLKTI NLQSLINNEI
260 270 280 290 300
PDCYTFSILI TFDNKAHSGR IPIRLETQTH IQECKHPSVS RHGDNSFRLL
310 320 330 340 350
FDVVVILTCS LSFLLCARSL LRGFLLQNEF VVFMWRRRGR EISLWERLEF
360 370 380 390 400
VNGWYILLVT SDVLTISGTI MKIGIEAKNL ASYDVCSILL GTSTLLVWVG
410 420 430 440 450
VIRYLTFFHK YNILIATLRV ALPSVMRFCC CVAVIYLGYC FCGWIVLGPY
460 470 480 490 500
HVKFRSLSMV SECLFSLING DDMFVTFAAM QAQQGRSSLV WLFSQLYLYS
510 520 530 540 550
FISLFIYMVL SLFIALITGA YDTIKHPGGT GTEKSELQAY IEQCQDSPTS
560 570 580
GKFRRGSGST CSLLCCCGRN SPEDHSLLVN
Length:580
Mass (Da):65,480
Last modified:April 20, 2010 - v1
Checksum:i2E7BE652EF47313B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07034959 Genomic DNA No translation available.
AABR07034960 Genomic DNA No translation available.
CH474084 Genomic DNA Translation: EDL74931.1
RefSeqiNP_001099373.1, NM_001105903.1
UniGeneiRn.106454

Genome annotation databases

EnsembliENSRNOT00000001290; ENSRNOP00000001290; ENSRNOG00000000975
GeneIDi288371
KEGGirno:288371
UCSCiRGD:1308953 rat

Similar proteinsi

Entry informationi

Entry nameiD3ZRF9_RAT
AccessioniPrimary (citable) accession number: D3ZRF9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health