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Protein
Submitted name:

Casein kinase I isoform alpha

Gene

Csnk1a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-195253 Degradation of beta-catenin by the destruction complex
R-RNO-196299 Beta-catenin phosphorylation cascade
R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
R-RNO-5635838 Activation of SMO

Names & Taxonomyi

Protein namesi
Submitted name:
Casein kinase I isoform alphaImported
Gene namesi
Name:Csnk1a1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi71098 Csnk1a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiD3ZRE3

Expressioni

Gene expression databases

BgeeiENSRNOG00000017106
ExpressionAtlasiD3ZRE3 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051516

Structurei

3D structure databases

ProteinModelPortaliD3ZRE3
SMRiD3ZRE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 313Protein kinaseInterPro annotationAdd BLAST297

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1164 Eukaryota
ENOG410XPGP LUCA
GeneTreeiENSGT00920000148982
OMAiGPDYMYL
OrthoDBiEOG091G0AFG
PhylomeDBiD3ZRE3
TreeFamiTF354246

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZRE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ
60 70 80 90 100
KARHPQLLYE SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL
110 120 130 140 150
FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC
160 170 180 190 200
NKCLESPVGK RKRSMTVSPS QDPSFSGLNQ LFLIDFGLAK KYRDNRTRQH
210 220 230 240 250
IPYREDKNLT GTARYASINA HLGIEQSRRD DMESLGYVLM YFNRTSLPWQ
260 270 280 290 300
GLKAATKKQK YEKISEKKMS TPVEVLCKGF PAEFAMYLNY CRGLRFEEAP
310 320 330 340 350
DYMYLRQLFR ILFRTLNHQY DYTFDWTMLK QKAAQQAASS SGQGQQAQTP
360
TGKQTDKTKS NMKGF
Length:365
Mass (Da):41,933
Last modified:April 20, 2010 - v1
Checksum:i0EC9BBB44E951A24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07032254 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000044346; ENSRNOP00000051516; ENSRNOG00000017106

Similar proteinsi

Entry informationi

Entry nameiD3ZRE3_RAT
AccessioniPrimary (citable) accession number: D3ZRE3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 20, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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