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Protein

Doublecortin domain-containing protein 2

Gene

Dcdc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex. Involved in the control of ciliogenesis and ciliary length (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Doublecortin domain-containing protein 2
Gene namesi
Name:Dcdc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1310227. Dcdc2.

Subcellular locationi

GO - Cellular componenti

  • axoneme Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • kinocilium Source: UniProtKB
  • nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Doublecortin domain-containing protein 2PRO_0000403481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD3ZR10.

PTM databases

iPTMnetiD3ZR10.
PhosphoSiteiD3ZR10.

Expressioni

Tissue specificityi

Expressed in hair cells of the inner ear.1 Publication

Gene expression databases

BgeeiENSRNOG00000017511.
GenevisibleiD3ZR10. RN.

Interactioni

Subunit structurei

Interacts with DVL1, DVL2 and DVL3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060289.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 10084Doublecortin 1PROSITE-ProRule annotationAdd
BLAST
Domaini139 – 22183Doublecortin 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 doublecortin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3757. Eukaryota.
ENOG410ZE6Q. LUCA.
GeneTreeiENSGT00510000046928.
InParanoidiD3ZR10.
OMAiRPMEVVN.
OrthoDBiEOG091G13U4.
PhylomeDBiD3ZR10.
TreeFamiTF338406.

Family and domain databases

CDDicd01617. DCX. 2 hits.
Gene3Di3.10.20.230. 2 hits.
InterProiIPR033036. DCDC2.
IPR003533. Doublecortin_dom.
[Graphical view]
PANTHERiPTHR23004:SF5. PTHR23004:SF5. 1 hit.
PfamiPF03607. DCX. 2 hits.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
[Graphical view]
PROSITEiPS50309. DC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZR10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGPSPRSSH LSQPVVKSVL VYRNGDPFFA GRRVVIHEKK VSSFDIFLKE
60 70 80 90 100
VTGGVQAPFG AVRNIYTPRT GHRIRKLDQI ESGGNYVAGG QEAFKKLNYL
110 120 130 140 150
DIGEIKKRPM EAVNTEVKPV IHSKINVSAR FRKALHEPCT IFLIANGDLI
160 170 180 190 200
SPASRLLIPR KALNQWDHVL QMVTEKITLR SGAVHRLYTL EGKLVESGAE
210 220 230 240 250
LENGQFYVAV GRDKFKRLPY SELLFDKSAM RRPYGQKASS LPPMVGSRKS
260 270 280 290 300
KGSGNYRQSK STIGSSDNSS PQPLKRKGKK DSNSEKPTKV KQSVKSKNSH
310 320 330 340 350
QAIPDNDEGI FKAGAERSET RGAAEVQEDE DTQVEVPVDQ RPAEIVDEEE
360 370 380 390 400
DGEKTSKDAN QKDDFSAMNG EAEDRAGSKV ADAPEEEEGI PDQGEKKASP
410 420 430 440 450
SRVNGGTDEE NGEELDQVTE ELQPTVDEKG KAEGDNSAQD EAGLDAQRPP
460 470
RPEVTVTSPQ ENEGNESNKA SSAVA
Length:475
Mass (Da):52,033
Last modified:April 20, 2010 - v1
Checksum:iA29B7868D7F264D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474064 Genomic DNA. Translation: EDL86488.1.
RefSeqiNP_001099580.2. NM_001106110.2.
UniGeneiRn.45430.

Genome annotation databases

EnsembliENSRNOT00000068021; ENSRNOP00000060289; ENSRNOG00000017511.
GeneIDi291130.
KEGGirno:291130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474064 Genomic DNA. Translation: EDL86488.1.
RefSeqiNP_001099580.2. NM_001106110.2.
UniGeneiRn.45430.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060289.

PTM databases

iPTMnetiD3ZR10.
PhosphoSiteiD3ZR10.

Proteomic databases

PaxDbiD3ZR10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068021; ENSRNOP00000060289; ENSRNOG00000017511.
GeneIDi291130.
KEGGirno:291130.

Organism-specific databases

CTDi51473.
RGDi1310227. Dcdc2.

Phylogenomic databases

eggNOGiKOG3757. Eukaryota.
ENOG410ZE6Q. LUCA.
GeneTreeiENSGT00510000046928.
InParanoidiD3ZR10.
OMAiRPMEVVN.
OrthoDBiEOG091G13U4.
PhylomeDBiD3ZR10.
TreeFamiTF338406.

Miscellaneous databases

PROiD3ZR10.

Gene expression databases

BgeeiENSRNOG00000017511.
GenevisibleiD3ZR10. RN.

Family and domain databases

CDDicd01617. DCX. 2 hits.
Gene3Di3.10.20.230. 2 hits.
InterProiIPR033036. DCDC2.
IPR003533. Doublecortin_dom.
[Graphical view]
PANTHERiPTHR23004:SF5. PTHR23004:SF5. 1 hit.
PfamiPF03607. DCX. 2 hits.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
[Graphical view]
PROSITEiPS50309. DC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCDC2_RAT
AccessioniPrimary (citable) accession number: D3ZR10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.