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Protein

Doublecortin domain-containing protein 2

Gene

Dcdc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein that plays a role in the inhibition of canonical Wnt signaling pathway (By similarity). May be involved in neuronal migration during development of the cerebral neocortex (PubMed:16278297). Involved in the control of ciliogenesis and ciliary length (By similarity).By similarity1 Publication

GO - Molecular functioni

  • kinesin binding Source: RGD

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Doublecortin domain-containing protein 2
Gene namesi
Name:Dcdc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1310227. Dcdc2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004034811 – 475Doublecortin domain-containing protein 2Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD3ZR10.
PRIDEiD3ZR10.

PTM databases

iPTMnetiD3ZR10.
PhosphoSitePlusiD3ZR10.

Expressioni

Tissue specificityi

Expressed in hair cells of the inner ear.1 Publication

Gene expression databases

BgeeiENSRNOG00000017511.
GenevisibleiD3ZR10. RN.

Interactioni

Subunit structurei

Interacts with DVL1, DVL2 and DVL3.By similarity

GO - Molecular functioni

  • kinesin binding Source: RGD

Protein-protein interaction databases

CORUMiD3ZR10.
STRINGi10116.ENSRNOP00000060289.

Structurei

3D structure databases

SMRiD3ZR10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 100Doublecortin 1PROSITE-ProRule annotationAdd BLAST84
Domaini139 – 221Doublecortin 2PROSITE-ProRule annotationAdd BLAST83

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3757. Eukaryota.
ENOG410ZE6Q. LUCA.
GeneTreeiENSGT00880000137957.
InParanoidiD3ZR10.
OMAiRPMEVVN.
OrthoDBiEOG091G13U4.
PhylomeDBiD3ZR10.
TreeFamiTF338406.

Family and domain databases

CDDicd01617. DCX. 2 hits.
Gene3Di3.10.20.230. 2 hits.
InterProiView protein in InterPro
IPR033036. DCDC2.
IPR003533. Doublecortin_dom.
IPR036572. Doublecortin_dom_sf.
PANTHERiPTHR23004:SF5. PTHR23004:SF5. 1 hit.
PfamiView protein in Pfam
PF03607. DCX. 2 hits.
SMARTiView protein in SMART
SM00537. DCX. 2 hits.
SUPFAMiSSF89837. SSF89837. 2 hits.
PROSITEiView protein in PROSITE
PS50309. DC. 2 hits.

Sequencei

Sequence statusi: Complete.

D3ZR10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGPSPRSSH LSQPVVKSVL VYRNGDPFFA GRRVVIHEKK VSSFDIFLKE
60 70 80 90 100
VTGGVQAPFG AVRNIYTPRT GHRIRKLDQI ESGGNYVAGG QEAFKKLNYL
110 120 130 140 150
DIGEIKKRPM EAVNTEVKPV IHSKINVSAR FRKALHEPCT IFLIANGDLI
160 170 180 190 200
SPASRLLIPR KALNQWDHVL QMVTEKITLR SGAVHRLYTL EGKLVESGAE
210 220 230 240 250
LENGQFYVAV GRDKFKRLPY SELLFDKSAM RRPYGQKASS LPPMVGSRKS
260 270 280 290 300
KGSGNYRQSK STIGSSDNSS PQPLKRKGKK DSNSEKPTKV KQSVKSKNSH
310 320 330 340 350
QAIPDNDEGI FKAGAERSET RGAAEVQEDE DTQVEVPVDQ RPAEIVDEEE
360 370 380 390 400
DGEKTSKDAN QKDDFSAMNG EAEDRAGSKV ADAPEEEEGI PDQGEKKASP
410 420 430 440 450
SRVNGGTDEE NGEELDQVTE ELQPTVDEKG KAEGDNSAQD EAGLDAQRPP
460 470
RPEVTVTSPQ ENEGNESNKA SSAVA
Length:475
Mass (Da):52,033
Last modified:April 20, 2010 - v1
Checksum:iA29B7868D7F264D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474064 Genomic DNA. Translation: EDL86488.1.
RefSeqiNP_001099580.2. NM_001106110.2.
UniGeneiRn.45430.

Genome annotation databases

EnsembliENSRNOT00000068021; ENSRNOP00000060289; ENSRNOG00000017511.
GeneIDi291130.
KEGGirno:291130.

Similar proteinsi

Entry informationi

Entry nameiDCDC2_RAT
AccessioniPrimary (citable) accession number: D3ZR10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: April 20, 2010
Last modified: November 22, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome