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Protein

Doublecortin domain-containing protein 2

Gene

Dcdc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein that plays a role in the inhibition of canonical Wnt signaling pathway (By similarity). May be involved in neuronal migration during development of the cerebral neocortex (PubMed:16278297). Involved in the control of ciliogenesis and ciliary length (By similarity).By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Doublecortin domain-containing protein 2
Gene namesi
Name:Dcdc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1310227 Dcdc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004034811 – 475Doublecortin domain-containing protein 2Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD3ZR10
PRIDEiD3ZR10

PTM databases

iPTMnetiD3ZR10
PhosphoSitePlusiD3ZR10

Expressioni

Tissue specificityi

Expressed in hair cells of the inner ear.1 Publication

Gene expression databases

BgeeiENSRNOG00000017511
GenevisibleiD3ZR10 RN

Interactioni

Subunit structurei

Interacts with DVL1, DVL2 and DVL3.By similarity

Protein-protein interaction databases

CORUMiD3ZR10
STRINGi10116.ENSRNOP00000060289

Structurei

3D structure databases

SMRiD3ZR10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 100Doublecortin 1PROSITE-ProRule annotationAdd BLAST84
Domaini139 – 221Doublecortin 2PROSITE-ProRule annotationAdd BLAST83

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3757 Eukaryota
ENOG410ZE6Q LUCA
GeneTreeiENSGT00880000137957
InParanoidiD3ZR10
OMAiRPMEVVN
OrthoDBiEOG091G13U4
PhylomeDBiD3ZR10
TreeFamiTF338406

Family and domain databases

CDDicd01617 DCX, 2 hits
Gene3Di3.10.20.230, 2 hits
InterProiView protein in InterPro
IPR033036 DCDC2
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
PANTHERiPTHR23004:SF5 PTHR23004:SF5, 1 hit
PfamiView protein in Pfam
PF03607 DCX, 2 hits
SMARTiView protein in SMART
SM00537 DCX, 2 hits
SUPFAMiSSF89837 SSF89837, 2 hits
PROSITEiView protein in PROSITE
PS50309 DC, 2 hits

Sequencei

Sequence statusi: Complete.

D3ZR10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGPSPRSSH LSQPVVKSVL VYRNGDPFFA GRRVVIHEKK VSSFDIFLKE
60 70 80 90 100
VTGGVQAPFG AVRNIYTPRT GHRIRKLDQI ESGGNYVAGG QEAFKKLNYL
110 120 130 140 150
DIGEIKKRPM EAVNTEVKPV IHSKINVSAR FRKALHEPCT IFLIANGDLI
160 170 180 190 200
SPASRLLIPR KALNQWDHVL QMVTEKITLR SGAVHRLYTL EGKLVESGAE
210 220 230 240 250
LENGQFYVAV GRDKFKRLPY SELLFDKSAM RRPYGQKASS LPPMVGSRKS
260 270 280 290 300
KGSGNYRQSK STIGSSDNSS PQPLKRKGKK DSNSEKPTKV KQSVKSKNSH
310 320 330 340 350
QAIPDNDEGI FKAGAERSET RGAAEVQEDE DTQVEVPVDQ RPAEIVDEEE
360 370 380 390 400
DGEKTSKDAN QKDDFSAMNG EAEDRAGSKV ADAPEEEEGI PDQGEKKASP
410 420 430 440 450
SRVNGGTDEE NGEELDQVTE ELQPTVDEKG KAEGDNSAQD EAGLDAQRPP
460 470
RPEVTVTSPQ ENEGNESNKA SSAVA
Length:475
Mass (Da):52,033
Last modified:April 20, 2010 - v1
Checksum:iA29B7868D7F264D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474064 Genomic DNA Translation: EDL86488.1
RefSeqiNP_001099580.2, NM_001106110.2
UniGeneiRn.45430

Genome annotation databases

EnsembliENSRNOT00000068021; ENSRNOP00000060289; ENSRNOG00000017511
GeneIDi291130
KEGGirno:291130

Similar proteinsi

Entry informationi

Entry nameiDCDC2_RAT
AccessioniPrimary (citable) accession number: D3ZR10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health