ID   APC15_RAT               Reviewed;         132 AA.
AC   D3ZQX4; D4ACX3;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   24-JAN-2024, entry version 80.
DE   RecName: Full=Anaphase-promoting complex subunit 15;
DE            Short=APC15;
GN   Name=Anapc15;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. In the
CC       complex, plays a role in the release of the mitotic checkpoint complex
CC       (MCC) from the APC/C: not required for APC/C activity itself, but
CC       promotes the turnover of CDC20 and MCC on the APC/C, thereby
CC       contributing to the responsiveness of the spindle assembly checkpoint.
CC       Also required for degradation of CDC20 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The mammalian APC/C is composed at least of 14 distinct
CC       subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6,
CC       ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and
CC       ANAPC16 that assemble into a complex of at least 19 chains with a
CC       combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1
CC       and FBXO5. {ECO:0000250|UniProtKB:P60006}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=D3ZQX4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=D3ZQX4-2; Sequence=VSP_043774;
CC   -!- SIMILARITY: Belongs to the APC15 family. {ECO:0000305}.
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DR   EMBL; CH473956; EDM18248.1; -; Genomic_DNA.
DR   EMBL; CH473956; EDM18249.1; -; Genomic_DNA.
DR   EMBL; CH473956; EDM18250.1; -; Genomic_DNA.
DR   RefSeq; NP_001163906.1; NM_001170435.1. [D3ZQX4-1]
DR   RefSeq; XP_006229922.1; XM_006229860.3. [D3ZQX4-1]
DR   RefSeq; XP_006229923.1; XM_006229861.3. [D3ZQX4-1]
DR   RefSeq; XP_006229924.1; XM_006229862.3. [D3ZQX4-1]
DR   RefSeq; XP_017444451.1; XM_017588962.1. [D3ZQX4-1]
DR   AlphaFoldDB; D3ZQX4; -.
DR   SMR; D3ZQX4; -.
DR   STRING; 10116.ENSRNOP00000027028; -.
DR   PaxDb; 10116-ENSRNOP00000027028; -.
DR   PeptideAtlas; D3ZQX4; -.
DR   Ensembl; ENSRNOT00000027028.7; ENSRNOP00000027028.4; ENSRNOG00000019936.8. [D3ZQX4-1]
DR   Ensembl; ENSRNOT00055049827; ENSRNOP00055041025; ENSRNOG00055028754. [D3ZQX4-1]
DR   Ensembl; ENSRNOT00060005203; ENSRNOP00060003839; ENSRNOG00060003166. [D3ZQX4-1]
DR   Ensembl; ENSRNOT00065038927; ENSRNOP00065031584; ENSRNOG00065022785. [D3ZQX4-1]
DR   GeneID; 293155; -.
DR   KEGG; rno:293155; -.
DR   UCSC; RGD:1311634; rat.
DR   AGR; RGD:1311634; -.
DR   CTD; 25906; -.
DR   RGD; 1311634; Anapc15.
DR   eggNOG; ENOG502RZUK; Eukaryota.
DR   GeneTree; ENSGT00390000000938; -.
DR   HOGENOM; CLU_142923_0_0_1; -.
DR   InParanoid; D3ZQX4; -.
DR   OrthoDB; 2963731at2759; -.
DR   Reactome; R-RNO-141430; Inactivation of APC/C via direct inhibition of the APC/C complex.
DR   Reactome; R-RNO-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
DR   Reactome; R-RNO-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR   Reactome; R-RNO-174154; APC/C:Cdc20 mediated degradation of Securin.
DR   Reactome; R-RNO-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR   Reactome; R-RNO-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR   Reactome; R-RNO-176407; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
DR   Reactome; R-RNO-176408; Regulation of APC/C activators between G1/S and early anaphase.
DR   Reactome; R-RNO-176412; Phosphorylation of the APC/C.
DR   Reactome; R-RNO-179409; APC-Cdc20 mediated degradation of Nek2A.
DR   Reactome; R-RNO-2467813; Separation of Sister Chromatids.
DR   Reactome; R-RNO-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR   Reactome; R-RNO-68867; Assembly of the pre-replicative complex.
DR   Reactome; R-RNO-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   PRO; PR:D3ZQX4; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Proteomes; UP000234681; Chromosome 1.
DR   Bgee; ENSRNOG00000019936; Expressed in thymus and 19 other cell types or tissues.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0090266; P:regulation of mitotic cell cycle spindle assembly checkpoint; ISS:UniProtKB.
DR   InterPro; IPR026182; ANAPC15.
DR   PANTHER; PTHR22526:SF2; ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED; 1.
DR   PANTHER; PTHR22526; UNCHARACTERIZED; 1.
DR   Pfam; PF15243; ANAPC15; 1.
DR   Genevisible; D3ZQX4; RN.
PE   3: Inferred from homology;
KW   Alternative splicing; Cell cycle; Cell division; Mitosis;
KW   Reference proteome.
FT   CHAIN           1..132
FT                   /note="Anaphase-promoting complex subunit 15"
FT                   /id="PRO_0000417538"
FT   REGION          58..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..124
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..10
FT                   /note="MEPGLKLSLG -> MRKLRPREVKCIGQSQTAR (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_043774"
SQ   SEQUENCE   132 AA;  15378 MW;  211303F56397D993 CRC64;
     MEPGLKLSLG AMSTLFPSLF PRVTETLWFN LDRPCVEETE LQQQEQQHQA WLQSIAEKDN
     NLVPIGKPAS EHYDDEEEED DEDDEDSEED SEDDEDMQDM DEMNDYNESP DDGEVNEVDM
     EGNEQDQDQW MI
//