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D3ZQX4

- APC15_RAT

UniProt

D3ZQX4 - APC15_RAT

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Protein

Anaphase-promoting complex subunit 15

Gene

Anapc15

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby contributing to the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20 (By similarity).By similarity

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 15
Short name:
APC15
Gene namesi
Name:Anapc15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1311634. Anapc15.

Subcellular locationi

GO - Cellular componenti

  1. anaphase-promoting complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Anaphase-promoting complex subunit 15PRO_0000417538Add
BLAST

Interactioni

Subunit structurei

The APC/C is composed of at least 12 subunits.By similarity

Structurei

3D structure databases

ProteinModelPortaliD3ZQX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 12855Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the APC15 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000000938.
InParanoidiD3ZQX4.
OMAiQTWLQSI.
OrthoDBiEOG70ZZRB.

Family and domain databases

InterProiIPR026182. ANAPC15.
[Graphical view]
PANTHERiPTHR22526. PTHR22526. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: D3ZQX4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPGLKLSLG AMSTLFPSLF PRVTETLWFN LDRPCVEETE LQQQEQQHQA
60 70 80 90 100
WLQSIAEKDN NLVPIGKPAS EHYDDEEEED DEDDEDSEED SEDDEDMQDM
110 120 130
DEMNDYNESP DDGEVNEVDM EGNEQDQDQW MI
Length:132
Mass (Da):15,378
Last modified:April 20, 2010 - v1
Checksum:i211303F56397D993
GO
Isoform 2 (identifier: D3ZQX4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MEPGLKLSLG → MRKLRPREVKCIGQSQTAR

Show »
Length:141
Mass (Da):16,592
Checksum:i9A92ED446CF5F2EB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1010MEPGLKLSLG → MRKLRPREVKCIGQSQTAR in isoform 2. CuratedVSP_043774

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473956 Genomic DNA. Translation: EDM18248.1.
CH473956 Genomic DNA. Translation: EDM18249.1.
CH473956 Genomic DNA. Translation: EDM18250.1.
RefSeqiNP_001163906.1. NM_001170435.1. [D3ZQX4-1]
XP_006229922.1. XM_006229860.2. [D3ZQX4-1]
XP_006229923.1. XM_006229861.2. [D3ZQX4-1]
XP_006229924.1. XM_006229862.2. [D3ZQX4-1]
UniGeneiRn.6268.

Genome annotation databases

EnsembliENSRNOT00000027028; ENSRNOP00000027028; ENSRNOG00000019936. [D3ZQX4-1]
GeneIDi293155.
KEGGirno:293155.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473956 Genomic DNA. Translation: EDM18248.1 .
CH473956 Genomic DNA. Translation: EDM18249.1 .
CH473956 Genomic DNA. Translation: EDM18250.1 .
RefSeqi NP_001163906.1. NM_001170435.1. [D3ZQX4-1 ]
XP_006229922.1. XM_006229860.2. [D3ZQX4-1 ]
XP_006229923.1. XM_006229861.2. [D3ZQX4-1 ]
XP_006229924.1. XM_006229862.2. [D3ZQX4-1 ]
UniGenei Rn.6268.

3D structure databases

ProteinModelPortali D3ZQX4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027028 ; ENSRNOP00000027028 ; ENSRNOG00000019936 . [D3ZQX4-1 ]
GeneIDi 293155.
KEGGi rno:293155.

Organism-specific databases

CTDi 25906.
RGDi 1311634. Anapc15.

Phylogenomic databases

GeneTreei ENSGT00390000000938.
InParanoidi D3ZQX4.
OMAi QTWLQSI.
OrthoDBi EOG70ZZRB.

Miscellaneous databases

NextBioi 635475.

Family and domain databases

InterProi IPR026182. ANAPC15.
[Graphical view ]
PANTHERi PTHR22526. PTHR22526. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiAPC15_RAT
AccessioniPrimary (citable) accession number: D3ZQX4
Secondary accession number(s): D4ACX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3