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D3ZQX4

- APC15_RAT

UniProt

D3ZQX4 - APC15_RAT

Protein

Anaphase-promoting complex subunit 15

Gene

Anapc15

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby contributing to the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20 By similarity.By similarity

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anaphase-promoting complex subunit 15
    Short name:
    APC15
    Gene namesi
    Name:Anapc15
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1311634. Anapc15.

    Subcellular locationi

    GO - Cellular componenti

    1. anaphase-promoting complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 132132Anaphase-promoting complex subunit 15PRO_0000417538Add
    BLAST

    Interactioni

    Subunit structurei

    The APC/C is composed of at least 12 subunits.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliD3ZQX4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi74 – 12855Asp-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the APC15 family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000000938.
    OMAiQTWLQSI.
    OrthoDBiEOG70ZZRB.

    Family and domain databases

    InterProiIPR026182. ANAPC15.
    [Graphical view]
    PANTHERiPTHR22526. PTHR22526. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: D3ZQX4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPGLKLSLG AMSTLFPSLF PRVTETLWFN LDRPCVEETE LQQQEQQHQA    50
    WLQSIAEKDN NLVPIGKPAS EHYDDEEEED DEDDEDSEED SEDDEDMQDM 100
    DEMNDYNESP DDGEVNEVDM EGNEQDQDQW MI 132
    Length:132
    Mass (Da):15,378
    Last modified:April 20, 2010 - v1
    Checksum:i211303F56397D993
    GO
    Isoform 2 (identifier: D3ZQX4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: MEPGLKLSLG → MRKLRPREVKCIGQSQTAR

    Show »
    Length:141
    Mass (Da):16,592
    Checksum:i9A92ED446CF5F2EB
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1010MEPGLKLSLG → MRKLRPREVKCIGQSQTAR in isoform 2. CuratedVSP_043774

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473956 Genomic DNA. Translation: EDM18248.1.
    CH473956 Genomic DNA. Translation: EDM18249.1.
    CH473956 Genomic DNA. Translation: EDM18250.1.
    RefSeqiNP_001163906.1. NM_001170435.1. [D3ZQX4-1]
    XP_006229922.1. XM_006229860.1. [D3ZQX4-1]
    XP_006229923.1. XM_006229861.1. [D3ZQX4-1]
    XP_006229924.1. XM_006229862.1. [D3ZQX4-1]
    XP_006229925.1. XM_006229863.1. [D3ZQX4-1]
    UniGeneiRn.6268.

    Genome annotation databases

    EnsembliENSRNOT00000027028; ENSRNOP00000027028; ENSRNOG00000019936. [D3ZQX4-1]
    GeneIDi293155.
    KEGGirno:293155.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473956 Genomic DNA. Translation: EDM18248.1 .
    CH473956 Genomic DNA. Translation: EDM18249.1 .
    CH473956 Genomic DNA. Translation: EDM18250.1 .
    RefSeqi NP_001163906.1. NM_001170435.1. [D3ZQX4-1 ]
    XP_006229922.1. XM_006229860.1. [D3ZQX4-1 ]
    XP_006229923.1. XM_006229861.1. [D3ZQX4-1 ]
    XP_006229924.1. XM_006229862.1. [D3ZQX4-1 ]
    XP_006229925.1. XM_006229863.1. [D3ZQX4-1 ]
    UniGenei Rn.6268.

    3D structure databases

    ProteinModelPortali D3ZQX4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027028 ; ENSRNOP00000027028 ; ENSRNOG00000019936 . [D3ZQX4-1 ]
    GeneIDi 293155.
    KEGGi rno:293155.

    Organism-specific databases

    CTDi 25906.
    RGDi 1311634. Anapc15.

    Phylogenomic databases

    GeneTreei ENSGT00390000000938.
    OMAi QTWLQSI.
    OrthoDBi EOG70ZZRB.

    Miscellaneous databases

    NextBioi 635475.

    Family and domain databases

    InterProi IPR026182. ANAPC15.
    [Graphical view ]
    PANTHERi PTHR22526. PTHR22526. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.

    Entry informationi

    Entry nameiAPC15_RAT
    AccessioniPrimary (citable) accession number: D3ZQX4
    Secondary accession number(s): D4ACX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2012
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3