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Protein

Anaphase-promoting complex subunit 15

Gene

Anapc15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby contributing to the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-RNO-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-RNO-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-RNO-174154. APC/C:Cdc20 mediated degradation of Securin.
R-RNO-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-RNO-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-RNO-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-RNO-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-RNO-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-RNO-176412. Phosphorylation of the APC/C.
R-RNO-179409. APC-Cdc20 mediated degradation of Nek2A.
R-RNO-2467813. Separation of Sister Chromatids.
R-RNO-2559582. Senescence-Associated Secretory Phenotype (SASP).

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 15
Short name:
APC15
Gene namesi
Name:Anapc15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311634. Anapc15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004175381 – 132Anaphase-promoting complex subunit 15Add BLAST132

Proteomic databases

PaxDbiD3ZQX4.
PeptideAtlasiD3ZQX4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019936.
GenevisibleiD3ZQX4. RN.

Interactioni

Subunit structurei

The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027028.

Structurei

3D structure databases

ProteinModelPortaliD3ZQX4.
SMRiD3ZQX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 128Asp-richAdd BLAST55

Sequence similaritiesi

Belongs to the APC15 family.Curated

Phylogenomic databases

eggNOGiENOG410J0F5. Eukaryota.
ENOG410Y01T. LUCA.
GeneTreeiENSGT00390000000938.
InParanoidiD3ZQX4.
OMAiQTWLQSI.
OrthoDBiEOG091G19LH.

Family and domain databases

InterProiIPR026182. ANAPC15.
[Graphical view]
PANTHERiPTHR22526. PTHR22526. 1 hit.
PfamiPF15243. ANAPC15. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: D3ZQX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPGLKLSLG AMSTLFPSLF PRVTETLWFN LDRPCVEETE LQQQEQQHQA
60 70 80 90 100
WLQSIAEKDN NLVPIGKPAS EHYDDEEEED DEDDEDSEED SEDDEDMQDM
110 120 130
DEMNDYNESP DDGEVNEVDM EGNEQDQDQW MI
Length:132
Mass (Da):15,378
Last modified:April 20, 2010 - v1
Checksum:i211303F56397D993
GO
Isoform 2 (identifier: D3ZQX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MEPGLKLSLG → MRKLRPREVKCIGQSQTAR

Show »
Length:141
Mass (Da):16,592
Checksum:i9A92ED446CF5F2EB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0437741 – 10MEPGLKLSLG → MRKLRPREVKCIGQSQTAR in isoform 2. Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473956 Genomic DNA. Translation: EDM18248.1.
CH473956 Genomic DNA. Translation: EDM18249.1.
CH473956 Genomic DNA. Translation: EDM18250.1.
RefSeqiNP_001163906.1. NM_001170435.1. [D3ZQX4-1]
XP_006229922.1. XM_006229860.3. [D3ZQX4-1]
XP_006229923.1. XM_006229861.3. [D3ZQX4-1]
XP_006229924.1. XM_006229862.3. [D3ZQX4-1]
XP_017444451.1. XM_017588962.1. [D3ZQX4-1]
UniGeneiRn.6268.

Genome annotation databases

EnsembliENSRNOT00000027028; ENSRNOP00000027028; ENSRNOG00000019936. [D3ZQX4-1]
GeneIDi293155.
KEGGirno:293155.
UCSCiRGD:1311634. rat.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473956 Genomic DNA. Translation: EDM18248.1.
CH473956 Genomic DNA. Translation: EDM18249.1.
CH473956 Genomic DNA. Translation: EDM18250.1.
RefSeqiNP_001163906.1. NM_001170435.1. [D3ZQX4-1]
XP_006229922.1. XM_006229860.3. [D3ZQX4-1]
XP_006229923.1. XM_006229861.3. [D3ZQX4-1]
XP_006229924.1. XM_006229862.3. [D3ZQX4-1]
XP_017444451.1. XM_017588962.1. [D3ZQX4-1]
UniGeneiRn.6268.

3D structure databases

ProteinModelPortaliD3ZQX4.
SMRiD3ZQX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027028.

Proteomic databases

PaxDbiD3ZQX4.
PeptideAtlasiD3ZQX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027028; ENSRNOP00000027028; ENSRNOG00000019936. [D3ZQX4-1]
GeneIDi293155.
KEGGirno:293155.
UCSCiRGD:1311634. rat.

Organism-specific databases

CTDi25906.
RGDi1311634. Anapc15.

Phylogenomic databases

eggNOGiENOG410J0F5. Eukaryota.
ENOG410Y01T. LUCA.
GeneTreeiENSGT00390000000938.
InParanoidiD3ZQX4.
OMAiQTWLQSI.
OrthoDBiEOG091G19LH.

Enzyme and pathway databases

ReactomeiR-RNO-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-RNO-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-RNO-174154. APC/C:Cdc20 mediated degradation of Securin.
R-RNO-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-RNO-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-RNO-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-RNO-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-RNO-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-RNO-176412. Phosphorylation of the APC/C.
R-RNO-179409. APC-Cdc20 mediated degradation of Nek2A.
R-RNO-2467813. Separation of Sister Chromatids.
R-RNO-2559582. Senescence-Associated Secretory Phenotype (SASP).

Miscellaneous databases

PROiD3ZQX4.

Gene expression databases

BgeeiENSRNOG00000019936.
GenevisibleiD3ZQX4. RN.

Family and domain databases

InterProiIPR026182. ANAPC15.
[Graphical view]
PANTHERiPTHR22526. PTHR22526. 1 hit.
PfamiPF15243. ANAPC15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPC15_RAT
AccessioniPrimary (citable) accession number: D3ZQX4
Secondary accession number(s): D4ACX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.