Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neutrophil immunoglobulin-like receptor 1

Gene

Nilr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Neutrophil immunoglobulin-like receptor 11 Publication
Gene namesi
Name:Nilr11 Publication
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70895. Nilr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 345322ExtracellularCuratedAdd
BLAST
Transmembranei346 – 36621HelicalSequence analysisAdd
BLAST
Topological domaini367 – 547181CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 547524Neutrophil immunoglobulin-like receptor 1PRO_0000435369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 99Curated
Disulfide bondi147 ↔ 199Curated
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi248 ↔ 299Curated
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expression detected in neutrophilic granulocytes.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 11986Ig-like C2-type 1Sequence analysisAdd
BLAST
Domaini132 – 22291Ig-like C2-type 2Sequence analysisAdd
BLAST
Domaini233 – 32189Ig-like C2-type 3Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi417 – 4226ITIM motif 11 Publication
Motifi446 – 4516ITIM motif 21 Publication
Motifi498 – 5036ITIM motif 31 Publication
Motifi528 – 5336ITIM motif 41 Publication

Domaini

Sequence similaritiesi

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Sequence analysis

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK06512.
PhylomeDBiD3ZQX2.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3ZQX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFTCKALLC LGMTLGLWIT VLTEFLPRPI LRVQPDTVVS TQSKVIFFCE
60 70 80 90 100
RSQGAELYCL YKKGNPRNPR CKEIRPKPGK KVEFFISKIE PYHAGHYHCY
110 120 130 140 150
YQIHGQWSED SDALELVVTG VYDYNELRLS VLPSPVVTVG RNMTLHCISH
160 170 180 190 200
SHYDKFILTK EDHKFTSSLD TQCIPPSGQC QALFVMGPMT SNHTGTFRCY
210 220 230 240 250
GYYKHTPQLW SIPSEPLEIH ISGLSKKPSL LTHQGHILDP GVNLTLQCCS
260 270 280 290 300
DINYDRFALY KVGGVDIMQH TSQQTDTGFS MTNFTLGYVH HSTGGQYRCY
310 320 330 340 350
GAHNLSSEWS ASSDPLDILI TGPIQMSTLP PITSMPPDQL ESYVNALIGV
360 370 380 390 400
SVAFLVFLFI LIFIILQRRH QRKFRKDGEE AQKEKELQYP TGAVEPISRD
410 420 430 440 450
RDQQKRSNAA AATQEESVYA SVEDMETEDG VELDTWKPPE GDPQGETYAQ
460 470 480 490 500
VKPSRLRRVE AIIPSAMSRE QLNTKYEQAE EGQEVDGQAT ESEEPQDVTY
510 520 530 540
AQLCSRTLRQ GTAAPPLSQA GEAPEEPSVY AALATACPGA VPKDKEQ
Length:547
Mass (Da):61,258
Last modified:January 20, 2016 - v3
Checksum:i44EBCAC3304D9A0C
GO

Sequence cautioni

The sequence EDL84917.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082534 mRNA. Translation: AAD29110.1.
AABR07071875 Genomic DNA. No translation available.
CH474101 Genomic DNA. Translation: EDL84917.1. Sequence problems.
RefSeqiNP_113901.2. NM_031713.1.
UniGeneiRn.207196.

Genome annotation databases

GeneIDi65146.
KEGGirno:65146.
UCSCiRGD:70895. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082534 mRNA. Translation: AAD29110.1.
AABR07071875 Genomic DNA. No translation available.
CH474101 Genomic DNA. Translation: EDL84917.1. Sequence problems.
RefSeqiNP_113901.2. NM_031713.1.
UniGeneiRn.207196.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi65146.
KEGGirno:65146.
UCSCiRGD:70895. rat.

Organism-specific databases

CTDi18733.
RGDi70895. Nilr1.

Phylogenomic databases

KOiK06512.
PhylomeDBiD3ZQX2.

Miscellaneous databases

NextBioi35569460.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NILR-1, a novel immunoglobulin-like receptor expressed by neutrophilic granulocytes, is encoded by a leukocyte receptor gene complex on rat chromosome 1."
    Berg S.F., Fossum S., Dissen E.
    Eur. J. Immunol. 29:2000-2006(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: PVGImported.
    Tissue: Natural killer cell1 Publication.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiNILR1_RAT
AccessioniPrimary (citable) accession number: D3ZQX2
Secondary accession number(s): A2J8C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: January 20, 2016
Last modified: April 13, 2016
This is version 52 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.