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Protein

Claudin-15

Gene

Cldn15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na+, Li+ and K+ ions, but selects against Cl- ions. Plays an important role in paracellular Na+ transport in the intestine and in Na+ homeostasis. Required for normal Na+-dependent intestinal nutrient uptake (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei55Important for Na(+)-selective paracellular ion transportBy similarity1
Sitei64Important for Na(+)-selective paracellular ion transportBy similarity1
Sitei68Important for the formation of tight-junction strand-like structuresBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-15
Gene namesi
Name:Cldn15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1310678. Cldn15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1CytoplasmicBy similarity1
Transmembranei2 – 24HelicalBy similarityAdd BLAST23
Topological domaini25 – 74ExtracellularBy similarityAdd BLAST50
Transmembranei75 – 99HelicalBy similarityAdd BLAST25
Topological domaini100 – 115CytoplasmicBy similarityAdd BLAST16
Transmembranei116 – 140HelicalBy similarityAdd BLAST25
Topological domaini141 – 159ExtracellularBy similarityAdd BLAST19
Transmembranei160 – 182HelicalBy similarityAdd BLAST23
Topological domaini183 – 227CytoplasmicBy similarityAdd BLAST45

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004295881 – 227Claudin-15Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 62By similarity
Modified residuei111PhosphoserineBy similarity1
Modified residuei211PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei217PhosphoserineCombined sources1

Post-translational modificationi

Palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiD3ZQJ0.

PTM databases

iPTMnetiD3ZQJ0.
PhosphoSitePlusiD3ZQJ0.

Expressioni

Tissue specificityi

Detected in kidney, jejunum and colon (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000001419.
GenevisibleiD3ZQJ0. RN.

Interactioni

Subunit structurei

Can form linear homooligomers in the membrane, giving rise to tight junction strand-like structures.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001923.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni146 – 147Important for the formation of tight-junction strand-like structuresBy similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKVT. Eukaryota.
ENOG410YHAD. LUCA.
GeneTreeiENSGT00760000119222.
InParanoidiD3ZQJ0.
KOiK06087.
OMAiIFENLWY.
OrthoDBiEOG091G0MX2.
PhylomeDBiD3ZQJ0.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR008094. Claudin15.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01718. CLAUDIN15.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3ZQJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIAVETFGF FMSALGLLML GVTLPNSYWR VSTVHGNVIT TNTIFENLWY
60 70 80 90 100
SCATDSLGVS NCWDFPSMLA LSGYVQGCRA LMITAILLGF LGLFLGMVGL
110 120 130 140 150
RCTNVGNIDL SRKAKLLAIA GAFHILAGAC GMVAISWYAV NITTDFFNPL
160 170 180 190 200
YVGTKYELGS ALYLGWSASL LSILGGICVF STCCCDSKED PATRVGLPYK
210 220
PSTVVTARAT SDESDVSFGK YGKNAYV
Length:227
Mass (Da):24,312
Last modified:April 20, 2010 - v1
Checksum:i2FEE2CBA883D6F82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06071124 Genomic DNA. No translation available.
AABR06071125 Genomic DNA. No translation available.
AABR06071126 Genomic DNA. No translation available.
CH473973 Genomic DNA. Translation: EDM13299.1.
RefSeqiNP_001100605.1. NM_001107135.2.
XP_006249217.1. XM_006249155.3.
UniGeneiRn.202600.

Genome annotation databases

EnsembliENSRNOT00000001923; ENSRNOP00000001923; ENSRNOG00000001419.
GeneIDi304388.
KEGGirno:304388.
UCSCiRGD:1310678. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06071124 Genomic DNA. No translation available.
AABR06071125 Genomic DNA. No translation available.
AABR06071126 Genomic DNA. No translation available.
CH473973 Genomic DNA. Translation: EDM13299.1.
RefSeqiNP_001100605.1. NM_001107135.2.
XP_006249217.1. XM_006249155.3.
UniGeneiRn.202600.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001923.

PTM databases

iPTMnetiD3ZQJ0.
PhosphoSitePlusiD3ZQJ0.

Proteomic databases

PaxDbiD3ZQJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001923; ENSRNOP00000001923; ENSRNOG00000001419.
GeneIDi304388.
KEGGirno:304388.
UCSCiRGD:1310678. rat.

Organism-specific databases

CTDi24146.
RGDi1310678. Cldn15.

Phylogenomic databases

eggNOGiENOG410IKVT. Eukaryota.
ENOG410YHAD. LUCA.
GeneTreeiENSGT00760000119222.
InParanoidiD3ZQJ0.
KOiK06087.
OMAiIFENLWY.
OrthoDBiEOG091G0MX2.
PhylomeDBiD3ZQJ0.
TreeFamiTF331936.

Miscellaneous databases

PROiD3ZQJ0.

Gene expression databases

BgeeiENSRNOG00000001419.
GenevisibleiD3ZQJ0. RN.

Family and domain databases

InterProiIPR006187. Claudin.
IPR008094. Claudin15.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01718. CLAUDIN15.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD15_RAT
AccessioniPrimary (citable) accession number: D3ZQJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.